1. Ion concentration measurement using synthetic microfluidic papers
- Author
-
Hiroki Yasuga, Norihisa Miki, and Haruka Kamiya
- Subjects
Physiology ,Computer science ,Potassium ,Microfluidics ,02 engineering and technology ,Urine ,01 natural sciences ,Filter Paper ,Medicine and Health Sciences ,Densitometer ,Measurement ,Multidisciplinary ,Sampling (statistics) ,021001 nanoscience & nanotechnology ,Body Fluids ,Laboratory Equipment ,Chemistry ,Blood ,Point-of-Care Testing ,Physical Sciences ,Engineering and Technology ,Medicine ,Fluidics ,Anatomy ,0210 nano-technology ,Biological system ,Research Article ,Chemical Elements ,Paper ,Sample (material) ,Science ,Densitometers ,Equipment ,chemistry.chemical_element ,Urinalysis ,Humans ,Saliva ,Measurement Equipment ,Filter paper ,010401 analytical chemistry ,Biology and Life Sciences ,Membranes, Artificial ,0104 chemical sciences ,chemistry ,Urine sample - Abstract
Non-invasive diagnosis on biological liquid samples, such as urine, sweat, saliva, and tears, may allow patients to evaluate their health by themselves. To obtain accurate diagnostic results, target liquid must be precisely sampled. Conventionally, urine sampling using filter paper can be given as an example sampling, but differences in the paper structure can cause variations in sampling volume. This paper describes precise liquid sampling using synthetic microfluidic papers, which are composed of obliquely combined micropillars. Sampling volume accuracy was investigated using different designs and collection methods to determine the optimal design and sample collecting method. The optimized protocol was followed to accurately measure potassium concentration using synthetic microfluidic paper and a commercially available densitometer, which verified the usefulness of the synthetic microfluidic papers for precision sampling.
- Published
- 2020