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Ion concentration measurement using synthetic microfluidic papers

Authors :
Hiroki Yasuga
Norihisa Miki
Haruka Kamiya
Source :
PLoS ONE, Vol 15, Iss 11, p e0242188 (2020), PLoS ONE
Publication Year :
2020
Publisher :
Public Library of Science (PLoS), 2020.

Abstract

Non-invasive diagnosis on biological liquid samples, such as urine, sweat, saliva, and tears, may allow patients to evaluate their health by themselves. To obtain accurate diagnostic results, target liquid must be precisely sampled. Conventionally, urine sampling using filter paper can be given as an example sampling, but differences in the paper structure can cause variations in sampling volume. This paper describes precise liquid sampling using synthetic microfluidic papers, which are composed of obliquely combined micropillars. Sampling volume accuracy was investigated using different designs and collection methods to determine the optimal design and sample collecting method. The optimized protocol was followed to accurately measure potassium concentration using synthetic microfluidic paper and a commercially available densitometer, which verified the usefulness of the synthetic microfluidic papers for precision sampling.

Details

Language :
English
ISSN :
19326203
Volume :
15
Issue :
11
Database :
OpenAIRE
Journal :
PLoS ONE
Accession number :
edsair.doi.dedup.....8943cf59591327a9dedbb96657195daa