Search

Your search keyword '"Iorizzi M"' showing total 4 results
Start Over Author "Iorizzi M" Journal planta medica
4 results on '"Iorizzi M"'

3. Imbricatolic acid from Juniperus communis L. prevents cell cycle progression in CaLu-6 cells.

Author

De Marino S, Cattaneo F, Festa C, Zollo F, Iaccio A, Ammendola R, Incollingo F, and Iorizzi M

Subjects
Animals, Antibodies, Cell Line, Tumor, Cell Survival, Cyclin-Dependent Kinase Inhibitor p21 metabolism, Cyclin-Dependent Kinases metabolism, Cyclins metabolism, Diterpenes chemistry, Diterpenes pharmacology, Fruit chemistry, Glycosides chemistry, Humans, Italy, Lignans chemistry, Mice, Plant Extracts chemistry, Plants, Medicinal chemistry, Rabbits, Spectrometry, Mass, Electrospray Ionization, Spectrometry, Mass, Fast Atom Bombardment, Time Factors, Tumor Suppressor Protein p53 genetics, Diterpenes isolation & purification, G1 Phase drug effects, Glycosides isolation & purification, Juniperus chemistry, Lignans isolation & purification, Plant Extracts isolation & purification
Abstract

Imbricatolic acid was isolated from the methanolic extract of the fresh ripe berries of Juniperus communis (Cupressaceae) together with sixteen known compounds and a new dihydrobenzofuran lignan glycoside named juniperoside A. Their structures were determined by spectroscopic methods and by comparison with the spectral data reported in literature. Imbricatolic acid was evaluated for its ability to prevent cell cycle progression in p53-null CaLu-6 cells. This compound induces the upregulation of cyclin-dependent kinase inhibitors and their accumulation in the G1 phase of the cell cycle, as well as the degradation of cyclins A, D1, and E1. Furthermore, no significant imbricatolic acid-induced apoptosis was observed. Therefore, this plant-derived compound may play a role in the control of cell cycle., (© Georg Thieme Verlag KG Stuttgart · New York.)

Published
2011
Full Text
View/download PDF

4. New sesquiterpene lactones from Laurus nobilis leaves as inhibitors of nitric oxide production.

Author

De Marino S, Borbone N, Zollo F, Ianaro A, Di Meglio P, and Iorizzi M

Subjects
Animals, Inhibitory Concentration 50, Lipopolysaccharides, Macrophages metabolism, Mice, Nitric Oxide antagonists & inhibitors, Plant Extracts administration & dosage, Plant Extracts chemistry, Plant Extracts therapeutic use, Plant Leaves, Sesquiterpenes administration & dosage, Sesquiterpenes chemistry, Sesquiterpenes pharmacology, Sesquiterpenes therapeutic use, Stereoisomerism, Laurus, Nitric Oxide biosynthesis, Phytotherapy, Plant Extracts pharmacology
Abstract

Two new metabolites 5alphaH,7alphaH-eudesman-4alpha,6alpha,11,12-tetraol (1) and 1beta,15-dihydroxy-5alphaH,7alphaH-eudesma-3,11(13)-dien-12,6alpha-olide ( 2) have been isolated from the methanolic extract of Laurus nobilis L. leaves. Their structures were determined through analysis of their one- and two-dimensional NMR spectral data ((1)H- and (13)C-NMR, DEPT, COSY, HMQC, HMBC and ROESY). The relative stereochemistry is proposed on the basis of combined J-based configuration analysis and ROESY data. In addition, three known sesquiterpene lactones santamarine (3), reynosin (4) and costunolide (5) along with blumenol C (6) were isolated and identified by spectral means. The isolated compounds 1 - 6 were found to inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophages. The most active compound 2 potently inhibited NO (2)(-) release with an IC (50) value of 0.8 microM.

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results