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Imbricatolic acid from Juniperus communis L. prevents cell cycle progression in CaLu-6 cells.
- Source :
-
Planta medica [Planta Med] 2011 Nov; Vol. 77 (16), pp. 1822-8. Date of Electronic Publication: 2011 May 12. - Publication Year :
- 2011
-
Abstract
- Imbricatolic acid was isolated from the methanolic extract of the fresh ripe berries of Juniperus communis (Cupressaceae) together with sixteen known compounds and a new dihydrobenzofuran lignan glycoside named juniperoside A. Their structures were determined by spectroscopic methods and by comparison with the spectral data reported in literature. Imbricatolic acid was evaluated for its ability to prevent cell cycle progression in p53-null CaLu-6 cells. This compound induces the upregulation of cyclin-dependent kinase inhibitors and their accumulation in the G1 phase of the cell cycle, as well as the degradation of cyclins A, D1, and E1. Furthermore, no significant imbricatolic acid-induced apoptosis was observed. Therefore, this plant-derived compound may play a role in the control of cell cycle.<br /> (© Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- Animals
Antibodies
Cell Line, Tumor
Cell Survival
Cyclin-Dependent Kinase Inhibitor p21 metabolism
Cyclin-Dependent Kinases metabolism
Cyclins metabolism
Diterpenes chemistry
Diterpenes pharmacology
Fruit chemistry
Glycosides chemistry
Humans
Italy
Lignans chemistry
Mice
Plant Extracts chemistry
Plants, Medicinal chemistry
Rabbits
Spectrometry, Mass, Electrospray Ionization
Spectrometry, Mass, Fast Atom Bombardment
Time Factors
Tumor Suppressor Protein p53 genetics
Diterpenes isolation & purification
G1 Phase drug effects
Glycosides isolation & purification
Juniperus chemistry
Lignans isolation & purification
Plant Extracts isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0221
- Volume :
- 77
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Planta medica
- Publication Type :
- Academic Journal
- Accession number :
- 21567359
- Full Text :
- https://doi.org/10.1055/s-0030-1271104