1. Cassane-type diterpenes from the seeds of Caesalpinia minax with their antineoplastic activity.
- Author
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Ma GX, Xu XD, Cao L, Yuan JQ, Yang JS, and Ma LY
- Subjects
- Antineoplastic Agents isolation & purification, Cytotoxins pharmacology, Diterpenes isolation & purification, Drugs, Chinese Herbal isolation & purification, HeLa Cells, Humans, Molecular Structure, Seeds chemistry, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Caesalpinia chemistry, Diterpenes chemistry, Diterpenes pharmacology, Drugs, Chinese Herbal chemistry, Drugs, Chinese Herbal pharmacology
- Abstract
Five new cassane-type diterpenes, neocaesalpin AA (1), neocaesalpin AB (2), neocaesalpin AC (3), neocaesalpin AD (4) and neocaesalpin AE (5), were isolated from Caesalpinia minax together with three known compounds, 12α-methoxyl,5α,14β-dihydroxy-1α,6α,7β-triacetoxycass-13(15)-en-16,12-olide (6), spirocaesalmin (7) and magnicaesalpin (8). Their structures were elucidated based on 1D and 2D NMR, MS and CD analyses. Compounds 1-6 were tested against Hela, HCT-8, HepG-2, MCF-7 and A549 cancer cells and showed moderate cytotoxicity with IC₅₀ values from 18.4 to 83.9 µM., (Georg Thieme Verlag KG Stuttgart · New York.)
- Published
- 2012
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