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Cassane-type diterpenes from the seeds of Caesalpinia minax with their antineoplastic activity.
- Source :
-
Planta medica [Planta Med] 2012 Aug; Vol. 78 (12), pp. 1363-9. Date of Electronic Publication: 2012 Jun 29. - Publication Year :
- 2012
-
Abstract
- Five new cassane-type diterpenes, neocaesalpin AA (1), neocaesalpin AB (2), neocaesalpin AC (3), neocaesalpin AD (4) and neocaesalpin AE (5), were isolated from Caesalpinia minax together with three known compounds, 12α-methoxyl,5α,14β-dihydroxy-1α,6α,7β-triacetoxycass-13(15)-en-16,12-olide (6), spirocaesalmin (7) and magnicaesalpin (8). Their structures were elucidated based on 1D and 2D NMR, MS and CD analyses. Compounds 1-6 were tested against Hela, HCT-8, HepG-2, MCF-7 and A549 cancer cells and showed moderate cytotoxicity with IC₅₀ values from 18.4 to 83.9 µM.<br /> (Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- Antineoplastic Agents isolation & purification
Cytotoxins pharmacology
Diterpenes isolation & purification
Drugs, Chinese Herbal isolation & purification
HeLa Cells
Humans
Molecular Structure
Seeds chemistry
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Caesalpinia chemistry
Diterpenes chemistry
Diterpenes pharmacology
Drugs, Chinese Herbal chemistry
Drugs, Chinese Herbal pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0221
- Volume :
- 78
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Planta medica
- Publication Type :
- Academic Journal
- Accession number :
- 22753035
- Full Text :
- https://doi.org/10.1055/s-0032-1314976