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5 results on '"Dobner B"'

1. [Protected mercaptoalkylpyrimidinones: synthesis and test for immunostimulating activity].

Author

Briel D, Drössler K, Rybak A, Holzer M, and Dobner B

Subjects
Animals, Antibody Formation drug effects, Guinea Pigs, Immunity, Cellular drug effects, Indicators and Reagents, Skin Tests, Adjuvants, Immunologic chemical synthesis, Adjuvants, Immunologic pharmacology, Pyrimidinones chemical synthesis, Pyrimidinones pharmacology, Sulfides chemical synthesis, Sulfides pharmacology
Abstract

Protected mercaptoalkylpyrimidinones: synthesis and test for immunostimulating activity 3-Hydroxyalkyl-pyrimidine 1 reacts with phosphoroxychloride and thioglycolic acid or thiourea to yield pyrimidin-3-ylalkylthioacetic acids 3 or pyrimidin-3-ylalkylthiouroniumsalts 5 respectively. Some of the pyrimidines 3 and 5 showed immunomodulatory activity.

Published
2005

2. [Synthesis of sulfanylalkylpyrimidine derivatives with potential immunomodulating action].

Author

Briel D, Holzer M, Leistner S, Drössler K, and Dobner B

Subjects
Animals, Antibody Formation drug effects, Dinitrofluorobenzene immunology, Guinea Pigs, Immunity, Cellular drug effects, Indicators and Reagents, Adjuvants, Immunologic chemical synthesis, Adjuvants, Immunologic pharmacology, Pyrimidines chemical synthesis, Pyrimidines pharmacology
Published
2003

3. [Synthesis of 2-substituted alkanolphosphoric acid esters with lytic effects].

Author

Nuhn P, Kertscher HP, Dobner B, Weissflog W, and Braune D

Subjects
Chemical Phenomena, Chemistry, Humans, In Vitro Techniques, Lethal Dose 50, Lysophosphatidylcholines pharmacology, Molecular Weight, Hemolysis drug effects, Lysophosphatidylcholines chemical synthesis
Abstract

Lysolipid analogues were synthetized and tested for haemolytic activity. Initial substances were long-chain 2-methylalkanols, as well as 2-hexadecylpropane-1,3-diol. The latter compound was prepared starting with hexadecylmalonic acid diester. Among the compounds synthetized, there were also 1-acetoxy-2-hexadecylpropan-3-ol-phosphocholine and acidic-reacting lysolipid analogues.

Published
1984

4. [Synthesis and biological activity of some lysing and fusogenically active phosphocholine derivatives].

Author

Nuhn P, Kertscher P, Dobner B, Braune KD, and Kluge S

Subjects
Chemical Phenomena, Chemistry, Humans, In Vitro Techniques, Phosphorylcholine chemical synthesis, Phosphorylcholine pharmacology, Protoplasts drug effects, Cell Fusion drug effects, Choline analogs & derivatives, Hemolysis drug effects, Phosphorylcholine analogs & derivatives
Abstract

2-Hexadecylglycerophosphocholine (1) and its 1-O-methyl, 1-O-ethyl and 1-O-benzyl (4) derivatives as well as some n-alkanol phosphocholines were synthetized and tested for haemolytic activity. Most potent (LD50 approximately equal to 5.10(-6) mol/l) were 1 and the hexadecanol and octadecanol phosphocholines (7 and 8). 1, 4 and 7 were tested for fusogenic activity against vegetable protoplasts. When used at sublytic concentrations (0.01 - 0.05 mmol), these compounds were as efficient as polyethylene glycol.

Published
1982

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