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[Protected mercaptoalkylpyrimidinones: synthesis and test for immunostimulating activity].
- Source :
-
Die Pharmazie [Pharmazie] 2005 Jun; Vol. 60 (6), pp. 415-7. - Publication Year :
- 2005
-
Abstract
- Protected mercaptoalkylpyrimidinones: synthesis and test for immunostimulating activity 3-Hydroxyalkyl-pyrimidine 1 reacts with phosphoroxychloride and thioglycolic acid or thiourea to yield pyrimidin-3-ylalkylthioacetic acids 3 or pyrimidin-3-ylalkylthiouroniumsalts 5 respectively. Some of the pyrimidines 3 and 5 showed immunomodulatory activity.
- Subjects :
- Animals
Antibody Formation drug effects
Guinea Pigs
Immunity, Cellular drug effects
Indicators and Reagents
Skin Tests
Adjuvants, Immunologic chemical synthesis
Adjuvants, Immunologic pharmacology
Pyrimidinones chemical synthesis
Pyrimidinones pharmacology
Sulfides chemical synthesis
Sulfides pharmacology
Subjects
Details
- Language :
- German
- ISSN :
- 0031-7144
- Volume :
- 60
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Die Pharmazie
- Publication Type :
- Academic Journal
- Accession number :
- 15997828