1. The role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in antidepressant-like effect
- Author
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Jacek Sapa, Karolina Pytka, Karolina Podkowa, Adrian Podkowa, Barbara Filipek, Katarzyna Młyniec, Elżbieta Żmudzka, Magdalena Jakubczyk, and Klaudia Lustyk
- Subjects
0301 basic medicine ,drug design ,Receptors, Melatonin ,receptors ,melatonin ,Tropomyosin receptor kinase B ,major ,Pharmacology ,antidepressive agents ,Melatonin ,03 medical and health sciences ,0302 clinical medicine ,Glucocorticoid receptor ,Receptors, Glucocorticoid ,depressive disorder ,Tachykinins ,medicine ,Animals ,Humans ,humans ,tachykinins ,Receptors, Tachykinin ,Depressive Disorder, Major ,biology ,General Medicine ,tachykinin ,medicine.disease ,Antidepressive Agents ,drug therapy ,animals ,030104 developmental biology ,Drug Design ,biology.protein ,Major depressive disorder ,Antidepressant ,glucocorticoid ,pharmacology ,physiopathology ,Psychology ,metabolism ,Tyrosine kinase ,030217 neurology & neurosurgery ,Glucocorticoid ,Neurotrophin ,medicine.drug - Abstract
Over the last few decades, depression has become one of the major public health problems in our society. This problem is connected not only with morbidity, but also with treatment, specifically with the effectiveness of the therapy as well as the concomitant side effects of available antidepressants. Major depressive disorder is a complex clinical entity, including different molecular mechanisms and neurological processes. This complexity is a challenge for scientists seeking to discover an innovatory antidepressant drug with multiple and complementary mechanisms of action. In this review, we discuss the role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in depression and antidepressant-like effects.
- Published
- 2016