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The role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in antidepressant-like effect
- Source :
- Pharmacological reports : PR. 69(3)
- Publication Year :
- 2016
-
Abstract
- Over the last few decades, depression has become one of the major public health problems in our society. This problem is connected not only with morbidity, but also with treatment, specifically with the effectiveness of the therapy as well as the concomitant side effects of available antidepressants. Major depressive disorder is a complex clinical entity, including different molecular mechanisms and neurological processes. This complexity is a challenge for scientists seeking to discover an innovatory antidepressant drug with multiple and complementary mechanisms of action. In this review, we discuss the role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in depression and antidepressant-like effects.
- Subjects :
- 0301 basic medicine
drug design
Receptors, Melatonin
receptors
melatonin
Tropomyosin receptor kinase B
major
Pharmacology
antidepressive agents
Melatonin
03 medical and health sciences
0302 clinical medicine
Glucocorticoid receptor
Receptors, Glucocorticoid
depressive disorder
Tachykinins
medicine
Animals
Humans
humans
tachykinins
Receptors, Tachykinin
Depressive Disorder, Major
biology
General Medicine
tachykinin
medicine.disease
Antidepressive Agents
drug therapy
animals
030104 developmental biology
Drug Design
biology.protein
Major depressive disorder
Antidepressant
glucocorticoid
pharmacology
physiopathology
Psychology
metabolism
Tyrosine kinase
030217 neurology & neurosurgery
Glucocorticoid
Neurotrophin
medicine.drug
Subjects
Details
- ISSN :
- 22995684
- Volume :
- 69
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Pharmacological reports : PR
- Accession number :
- edsair.doi.dedup.....17eaa8d353b7fa8a1b20fb090aa0d7de