1. A controlled trial of intra-articular corticosteroids with or without methotrexate in oligoarticular juvenile idiopathic arthritis
- Author
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Angelo Ravelli, Valeria Gerloni, Alessandro Consolaro, C Maggio, Alberto Martini, Donato Rigante, Adele Civino, Bianca Lattanzi, Antonella Buoncompagni, Giulia Bracciolini, Marco Gattorno, Franco Garofalo, Loredana Lepore, S Dalprà, Stefania Viola, Sergio Davì, Antonella Insalaco, Luciana Breda, Maurizio Gattinara, Clara Malattia, Giovanni Filocamo, Silvia Magni-Manzoni, F De Benedetti, N Ruperto, Paolo Picco, G Presta, Angela Pistorio, Sara Verazza, Bracciolini1 GP, Davì S, Pistorio A, Consolaro A, Verazza S, Lattanzi B, Filocamo G, Dalprà S, Gattinara M, Gerloni V, Insalaco A, De Benedetti F, Civino A, Presta G, Breda L, Lepore L, Maggio C, Garofalo F, Magni-Manzoni S, Rigante D, Buoncompagni A, Gattorno M, Malattia C, Picco P, Viola S, Ruperto N, Martini A, and Ravelli A
- Subjects
musculoskeletal diseases ,Pediatrics ,medicine.medical_specialty ,Arthritis ,law.invention ,Settore MED/38 - Pediatria Generale E Specialistica ,Rheumatology ,Randomized controlled trial ,law ,Internal medicine ,Synovitis ,medicine ,Immunology and Allergy ,Pediatrics, Perinatology, and Child Health ,skin and connective tissue diseases ,methotrexate, oligoarticular, juvenile idiopathic arthritis ,Oligoarthritis ,business.industry ,medicine.disease ,Concomitant ,Poster Presentation ,Pediatrics, Perinatology and Child Health ,Methotrexate ,Oligoarticular Juvenile Idiopathic Arthritis ,business ,medicine.drug - Abstract
In contrast with the numerous controlled trials conducted in polyarticular or systemic juvenile idiopathic arthritis (JIA), little evidence-based information is available for oligoarticular JIA. As a result, the management of children with this subtype, which is the most prevalent in Western countries, is largely empiric. Intra-articular corticosteroid (IAC) injection is the therapy of first choice for oligoarthritis in many pediatric rheumatology centers. However, although IAC injections are usually highly efficacious, relapses of synovitis are common and sometimes occur only a few months after the procedure. It is still unclear whether concomitant administration of methotrexate (MTX) may increase and prolong the effectiveness of IAC injections.
- Published
- 2014
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