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Your search keyword '"Vanderschueren-Lodeweyckx, M."' showing total 19 results
Start Over Author "Vanderschueren-Lodeweyckx, M." Journal pediatric research
19 results on '"Vanderschueren-Lodeweyckx, M."'

3. The Effect of Exogenous 3′: 5′-Adenosine Monophosphate on Urinary Output in Children with Vasopressin-Resistant Diabetes Insipidus

Author

Proesmans, W, Eggermont, E, Vanderschueren-Lodeweyckx, M, Tiddens, H, and Eeckels, R

Abstract

Extract: 3′:5′-Adenosine monophosphate (c-AMP) and dibutyryl 3′:5′-adenosine monophosphate (DB c-AMP) were given intravenously to six children with nephrogenic diabetes insipidus. Both nucleotides were unable to reduce, in a constant and reproducible manner, urine volume and free water clearance. Paradoxically, DB c-AMP, given as an infusion, caused a clear-cut rise in urine volume (an increase of 138.0—188.5%, mean of 172.8%, as compared with the preceding periods) without influencing creatinine excretion.Speculation: In nephrogenic diabetes insipidus, the basic defect responsible for vasopressin resistance presumably is located beyond the intracellular c-AMP formation. DB c-AMP might diminish the net reabsorption of water and solutes in the proximal renal tubule.

Published
1975
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17. Serum growth hormone-binding proteins in the human fetus and infant.

Author

Massa G, de Zegher F, and Vanderschueren-Lodeweyckx M

Subjects
Birth Weight, Gestational Age, Humans, Infant, Infant, Newborn, Nutritional Status, Carrier Proteins blood, Fetal Blood metabolism, Growth Hormone blood
Abstract

Growth hormone-binding protein (GH-BP) levels were studied in cord serum of 69 human infants born after 24 to 41 wk of gestation and in serum of 14 infants aged 1 to 3 mo. GH-BP levels were measured by HPLC-gel filtration of serum incubated overnight with 125I-hGH. The radioactive elution profile revealed two small 125I-hGH peaks of high molecular weight and a large peak, corresponding to monomeric 125I-hGH. The first peak of high molecular weight was variable, showed some of the characteristics (high molecular weight, displaceability by a large excess of unlabeled hGH) of the described low affinity, high capacity GH-BP, and did not correlate with gestational age or birth weight (peak I-BP). The second peak was identified as 125I-hGH bound to the high affinity, low capacity GH-BP (peak II-BP). Mean +/- SD specific binding of 125I-hGH to this peak was significantly (p less than 0.0001) different between preterm infants (3.1 +/- 1.1%; n = 51), term infants at birth (4.2 +/ 1.1%; n = 18), and 1- to 3-mo-old infants (8.5 +/- 1.6%; n = 14). To evaluate the effect of intrauterine nutritional state, the ponderal index (weight/lengths) was calculated. Peak II-BP levels were lower (p less than 0.05) in infants with the ponderal index less than 2.35 (2.8 +/- 1.0%; n = 20) than in those with the ponderal index between 2.35 and 2.65 (3.4 +/- 1.2%; n = 29) or greater than 2.65 (3.8 +/- 1.2%; n = 20).(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1992
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18. Subcutaneous adipose tissue and lipids in blood in growth hormone deficiency before and after treatment with human growth hormone.

Author

Bonnet F, Vanderschueren-Lodeweyckx M, Eeckels R, and Malvaux P

Subjects
Adipose Tissue analysis, Adolescent, Age Determination by Skeleton, Age Factors, Arginine, Biopsy, Child, Chromatography, Gas, Fatty Acids analysis, Fatty Acids blood, Female, Glucagon, Growth Hormone administration & dosage, Growth Hormone blood, Humans, Hypopituitarism blood, Hypopituitarism pathology, Insulin, Male, Pituitary Function Tests, Radioimmunoassay, Skinfold Thickness, Triglycerides analysis, Adipose Tissue pathology, Growth Hormone therapeutic use, Hypopituitarism drug therapy, Lipids blood
Published
1974
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19. The effect of exogenous 3':5'-adenosine monophosphate on urinary output in children with vasopressin-resistant diabetes insipidus.

Author

Proesmans W, Eggermont E, Vanderschueren-Lodeweyckx M, Tiddens H, and Eeckels R

Subjects
Bucladesine administration & dosage, Bucladesine metabolism, Child, Child, Preschool, Creatinine urine, Cyclic AMP administration & dosage, Cyclic AMP metabolism, Diabetes Insipidus urine, Diuresis, Female, Humans, Infant, Injections, Intravenous, Male, Osmolar Concentration, Vasopressins administration & dosage, Vasopressins therapeutic use, Bucladesine therapeutic use, Cyclic AMP therapeutic use, Diabetes Insipidus drug therapy, Vasopressins metabolism
Abstract

The administration of c-AMP and DB c-AMP to six children with NDI has failed to yield an antidiuretic effect. From the present study it may be concluded that, at the doses used, neither c-AMP nor its dibutyryl derivative can mimic the action of ADH in NDI as they do in normal subjects. On the contrary, DB c-AMP increased urine volume and Cosm in a very marked way, without changing the creatinine excretion.

Published
1975
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