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The effect of exogenous 3':5'-adenosine monophosphate on urinary output in children with vasopressin-resistant diabetes insipidus.
- Source :
-
Pediatric research [Pediatr Res] 1975 May; Vol. 9 (5), pp. 509-12. - Publication Year :
- 1975
-
Abstract
- The administration of c-AMP and DB c-AMP to six children with NDI has failed to yield an antidiuretic effect. From the present study it may be concluded that, at the doses used, neither c-AMP nor its dibutyryl derivative can mimic the action of ADH in NDI as they do in normal subjects. On the contrary, DB c-AMP increased urine volume and Cosm in a very marked way, without changing the creatinine excretion.
- Subjects :
- Bucladesine administration & dosage
Bucladesine metabolism
Child
Child, Preschool
Creatinine urine
Cyclic AMP administration & dosage
Cyclic AMP metabolism
Diabetes Insipidus urine
Diuresis
Female
Humans
Infant
Injections, Intravenous
Male
Osmolar Concentration
Vasopressins administration & dosage
Vasopressins therapeutic use
Bucladesine therapeutic use
Cyclic AMP therapeutic use
Diabetes Insipidus drug therapy
Vasopressins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0031-3998
- Volume :
- 9
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Pediatric research
- Publication Type :
- Academic Journal
- Accession number :
- 166349
- Full Text :
- https://doi.org/10.1203/00006450-197505000-00009