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Maximum length sequence brainstem auditory evoked response (BAER) was studied within the first week after birth in 28 term neonates who had perinatal hypoxia-ischemia, or asphyxia. In the BAER recorded using conventional averaging techniques (click rate 21/s), the only abnormality was a slight increase in III-V interval, in addition to an increase in wave latencies when including those who had an elevated threshold (t test, all p<0.05). In the maximum length sequence BAER, however, both the III-V and I-V intervals in the asphyxiated infants were significantly increased at all the 91/s, 227/s, 455/s, and particularly 910/s click rates (p<0.05-0.001). The I-III interval was also increased significantly at 455/s and 910/s click rates (both p< 0.05). Wave V amplitude was significantly reduced at all the click rates used (ANOVA, p<0.05-0.001), particularly at 910/s, which sometimes was the only abnormality indicative of brain damage. Both the amplitude ratios V/I and V/III were significantly decreased at 455/s and 910/s click rates (p<0.01 or 0.001). A general trend was that BAER abnormalities after hypoxia-ischemia became more prominent as click rate was increased. Significant abnormalities occurred mainly at very high click rates (455/s and 910/s), which can be achieved using the maximum length sequence technique but not by using conventional averaging techniques. Thus, this technique, which can be used at the cribside, appears to be a better method for the early detection of brain damage after hypoxia-ischemia than using conventional averaging techniques, enhancing the diagnostic value of the BAER.

Binaural interaction (BI) in brainstem auditory evoked response (BAER) were examined in normal term neonates. The BI components coincided consistently with the latency range of BAER wave IV through wave VII. Most BI components seen in the adults could be identified in the neonates, but the later components, i.e. those with longer latency, were underdeveloped in wave form. Wave DV was the most consistent and reproducible BI component. A marked difference between the neonatal and adult BI wave forms was that wave DVII was particularly small in the neonates. It appears that neuronal responses contributing to later BI components such as wave DVII are particularly immature at birth. Wave latencies and interpeak intervals were longer and amplitudes were smaller in the neonates than in the adults, which was associated with the differences between the neonates and adults in the BAER components. Changes in the BI components with stimulus intensity and rate in the neonates were fundamentally similar to but more significant compared with those in the adults. These findings suggest that neural connections in human auditory brainstem subserving the BI are established at birth but, particularly at higher levels of the brainstem, are immature.