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Maximum length sequence brainstem auditory evoked responses in term neonates who have perinatal hypoxia-ischemia.
- Source :
-
Pediatric research [Pediatr Res] 2000 Nov; Vol. 48 (5), pp. 639-45. - Publication Year :
- 2000
-
Abstract
- Maximum length sequence brainstem auditory evoked response (BAER) was studied within the first week after birth in 28 term neonates who had perinatal hypoxia-ischemia, or asphyxia. In the BAER recorded using conventional averaging techniques (click rate 21/s), the only abnormality was a slight increase in III-V interval, in addition to an increase in wave latencies when including those who had an elevated threshold (t test, all p<0.05). In the maximum length sequence BAER, however, both the III-V and I-V intervals in the asphyxiated infants were significantly increased at all the 91/s, 227/s, 455/s, and particularly 910/s click rates (p<0.05-0.001). The I-III interval was also increased significantly at 455/s and 910/s click rates (both p< 0.05). Wave V amplitude was significantly reduced at all the click rates used (ANOVA, p<0.05-0.001), particularly at 910/s, which sometimes was the only abnormality indicative of brain damage. Both the amplitude ratios V/I and V/III were significantly decreased at 455/s and 910/s click rates (p<0.01 or 0.001). A general trend was that BAER abnormalities after hypoxia-ischemia became more prominent as click rate was increased. Significant abnormalities occurred mainly at very high click rates (455/s and 910/s), which can be achieved using the maximum length sequence technique but not by using conventional averaging techniques. Thus, this technique, which can be used at the cribside, appears to be a better method for the early detection of brain damage after hypoxia-ischemia than using conventional averaging techniques, enhancing the diagnostic value of the BAER.
- Subjects :
- Acoustic Stimulation
Age Factors
Asphyxia Neonatorum complications
Brain Injuries diagnosis
Brain Injuries etiology
Brain Injuries physiopathology
Female
Humans
Hypoxia-Ischemia, Brain complications
Infant, Newborn
Male
Asphyxia Neonatorum physiopathology
Evoked Potentials, Auditory, Brain Stem
Hypoxia-Ischemia, Brain physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0031-3998
- Volume :
- 48
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Pediatric research
- Publication Type :
- Academic Journal
- Accession number :
- 11044485
- Full Text :
- https://doi.org/10.1203/00006450-200011000-00015