1. Two Novel Glycosidic Triterpene Alkaloids from the Stem Barks of Machilus yaoshansis
- Author
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Ying-Hong Wang, Yongchun Yang, Wen-Yi He, Sujuan Wang, Shuai Li, Sheng Lin, Mingtao Liu, and Jiangong Shi
- Subjects
chemistry.chemical_classification ,Magnetic Resonance Spectroscopy ,Molecular Structure ,biology ,Stereochemistry ,Organic Chemistry ,Glycosidic bond ,biology.organism_classification ,Biochemistry ,Adenosine ,Triterpenes ,Lauraceae ,Alkaloids ,chemistry ,Triterpene ,Cell culture ,Machilus ,Plant Bark ,medicine ,Glycosides ,Physical and Theoretical Chemistry ,Human cancer ,medicine.drug - Abstract
[structure: see text] Two unusual glycosidic triterpene alkaloids, machilaminosides A (1) and B (2), have been isolated from the stem barks of Machilus yaoshansis. Their structures were elucidated by detailed spectroscopic analysis. A possible biogenetic origin of 1 and 2 mediated by the coupling of 2-O-beta-D-glucopyranosyl-cucurbitacin I, respectively, with urea and adenosine was postulated. 1 and 2 showed nonselective cytotoxic activities against several human cancer cell lines as well as TNF-alpha secretion inhibitory activities.
- Published
- 2006
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