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Two Novel Glycosidic Triterpene Alkaloids from the Stem Barks of Machilus yaoshansis
- Source :
- Organic Letters. 9:129-132
- Publication Year :
- 2006
- Publisher :
- American Chemical Society (ACS), 2006.
-
Abstract
- [structure: see text] Two unusual glycosidic triterpene alkaloids, machilaminosides A (1) and B (2), have been isolated from the stem barks of Machilus yaoshansis. Their structures were elucidated by detailed spectroscopic analysis. A possible biogenetic origin of 1 and 2 mediated by the coupling of 2-O-beta-D-glucopyranosyl-cucurbitacin I, respectively, with urea and adenosine was postulated. 1 and 2 showed nonselective cytotoxic activities against several human cancer cell lines as well as TNF-alpha secretion inhibitory activities.
- Subjects :
- chemistry.chemical_classification
Magnetic Resonance Spectroscopy
Molecular Structure
biology
Stereochemistry
Organic Chemistry
Glycosidic bond
biology.organism_classification
Biochemistry
Adenosine
Triterpenes
Lauraceae
Alkaloids
chemistry
Triterpene
Cell culture
Machilus
Plant Bark
medicine
Glycosides
Physical and Theoretical Chemistry
Human cancer
medicine.drug
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....9348f15080ff414ce889bf3b7b4036d3