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3 results on '"Min-Ah Lee"'

1. Ieodoglucomides A and B from a Marine-Derived Bacterium Bacillus licheniformis

Author

Fakir Shahidullah Tareq, Hyi-Seung Lee, Ji Hye Kim, Yeon-Ju Lee, Hee Jae Shin, Min Ah Lee, and Jong Seok Lee

Subjects
chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Fatty acid, Antineoplastic Agents, Bacillus, Marine Biology, Antimicrobial, biology.organism_classification, Biochemistry, In vitro, Amino acid, chemistry.chemical_compound, chemistry, Succinic acid, Humans, Bacillus licheniformis, Drug Screening Assays, Antitumor, Physical and Theoretical Chemistry, Sugar, Glycoconjugates, Nuclear Magnetic Resonance, Biomolecular, Bacteria
Abstract

Ieodoglucomides A (1) and B (2), unique glycolipopeptides consisting of an amino acid, a new fatty acid, a succinic acid, and a sugar, were isolated from a Marine-derived bacterium Bacillus licheniformis. The absolute stereochemistry of 1 and 2 was determined by deploying coupling constants, Marfey's and Mosher's methods, and literature reviews. Compounds 1 and 2 displayed moderate in vitro antimicrobial activity. Furthermore, ieodoglucomide B (2) exhibited cytotoxic activity against lung cancer and stomach cancer cell lines with GI(50) values of 25.18 and 17.78 μg/mL, respectively.

Published
2012

2. Gageotetrins A-C, noncytotoxic antimicrobial linear lipopeptides from a marine bacterium Bacillus subtilis

Author

Choudhury M. Hasan, Yeon-Ju Lee, Hee Jae Shin, Hyi-Seung Lee, Min Ah Lee, Jong Seok Lee, Md. Tofazzal Islam, and Fakir Shahidullah Tareq

Subjects
Bacillus subtilis, Microbial Sensitivity Tests, Biochemistry, chemistry.chemical_compound, Lipopeptides, Anti-Infective Agents, Cell Line, Tumor, Humans, Physical and Theoretical Chemistry, Derivatization, Cytotoxicity, Nuclear Magnetic Resonance, Biomolecular, chemistry.chemical_classification, biology, Molecular Structure, Organic Chemistry, Fatty Acids, Fatty acid, biology.organism_classification, Antimicrobial, chemistry, Cell culture, Fermentation, Drug Screening Assays, Antitumor, Bacteria
Abstract

Gageotetrins A-C (1-3), a unique class of linear lipopeptides, consisting of di- and tetrapeptides and a new fatty acid were isolated from a Marine Bacillus subtilis. The structures of 1-3 were assigned by spectroscopic data and their absolute stereochemistries were ascertained by chemical derivatization. Compounds 1-3 displayed good antimicrobial activities with MIC values of 0.01-0.06 μM. However, these compounds failed to register any cytotoxicity (GI50 > 30 μg/ml) against human cancer cell lines.

Published
2014

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