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Ieodoglucomides A and B from a Marine-Derived Bacterium Bacillus licheniformis
- Source :
- Organic Letters. 14:1464-1467
- Publication Year :
- 2012
- Publisher :
- American Chemical Society (ACS), 2012.
-
Abstract
- Ieodoglucomides A (1) and B (2), unique glycolipopeptides consisting of an amino acid, a new fatty acid, a succinic acid, and a sugar, were isolated from a Marine-derived bacterium Bacillus licheniformis. The absolute stereochemistry of 1 and 2 was determined by deploying coupling constants, Marfey's and Mosher's methods, and literature reviews. Compounds 1 and 2 displayed moderate in vitro antimicrobial activity. Furthermore, ieodoglucomide B (2) exhibited cytotoxic activity against lung cancer and stomach cancer cell lines with GI(50) values of 25.18 and 17.78 μg/mL, respectively.
- Subjects :
- chemistry.chemical_classification
Molecular Structure
biology
Organic Chemistry
Fatty acid
Antineoplastic Agents
Bacillus
Marine Biology
Antimicrobial
biology.organism_classification
Biochemistry
In vitro
Amino acid
chemistry.chemical_compound
chemistry
Succinic acid
Humans
Bacillus licheniformis
Drug Screening Assays, Antitumor
Physical and Theoretical Chemistry
Sugar
Glycoconjugates
Nuclear Magnetic Resonance, Biomolecular
Bacteria
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....cc33c582f30b566a27b41ccf75fc0f3d