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Your search keyword '"Yoshitaka Sekido"' showing total 2 results
Start Over Author "Yoshitaka Sekido" Topic mesothelioma Journal organic letters
2 results on '"Yoshitaka Sekido"'

1. JBIR-23 and -24, novel anticancer agents from Streptomyces sp. AK-AB27

Author

Ji-Hwan Hwang, Motoki Takagi, Kazuo Shin-ya, Keiichiro Motohashi, and Yoshitaka Sekido

Subjects
Mesothelioma, biology, Pleural mesothelioma, Stereochemistry, Organic Chemistry, Drug Evaluation, Preclinical, Antineoplastic Agents, biology.organism_classification, Biochemistry, Streptomyces, chemistry.chemical_compound, chemistry, Cell culture, Furan, Cell Line, Tumor, Cytotoxic T cell, Humans, Physical and Theoretical Chemistry, Benzofurans
Abstract

The screening for active compounds against malignant pleural mesothelioma (MPM) cells produced by Streptomyces sp. AK-AB27 resulted in the isolation of two compounds with a dodecahydrodibenzo[b,d]furan skeleton named JBIR-23 (1) and -24 (2). Their structures were established on the basis of extensive NMR and MS analyses. Compounds 1 and 2 exhibited cytotoxic effects against several MPM cell lines.

Published
2008

2. JBIR-23 and -24, Novel Anticancer Agents from Streptomycessp. AK-AB27.

Author

Keiichiro Motohashi, Ji-Hwan Hwang, Yoshitaka Sekido, Motoki Takagi, and Kazuo Shin-ya

Subjects
*ANTINEOPLASTIC agents, *STREPTOMYCES, *MESOTHELIOMA, *FURANS, *CHEMICAL structure, *NUCLEAR magnetic resonance, *MASS spectrometry, *THERAPEUTICS
Abstract

The screening for active compounds against malignant pleural mesothelioma (MPM) cells produced by Streptomycessp. AK-AB27 resulted in the isolation of two compounds with a dodecahydrodibenzo[b,d]furan skeleton named JBIR-23 (1) and -24 (2). Their structures were established on the basis of extensive NMR and MS analyses. Compounds 1and 2exhibited cytotoxic effects against several MPM cell lines. [ABSTRACT FROM AUTHOR]

Published
2009
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