1. Skeletal muscle mass is an imaging biomarker for decreased survival in patients with oropharyngeal squamous cell carcinoma
- Author
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Inge Wegner, Sandra I. Bril, R. de Bree, Najiba Chargi, Justin E. Swartz, and Stefan M. Willems
- Subjects
Oncology ,Male ,Cancer Research ,medicine.medical_specialty ,Sarcopenia ,Multivariate analysis ,Imaging biomarker ,Kaplan-Meier Estimate ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Positron Emission Tomography Computed Tomography ,medicine ,Humans ,Sarcopenic obesity ,Oropharyngeal squamous cell carcinoma ,030223 otorhinolaryngology ,Muscle, Skeletal ,Proportional Hazards Models ,Retrospective Studies ,Proportional hazards model ,business.industry ,Head and neck cancer ,medicine.disease ,Skeletal muscle mass ,Prognosis ,Oropharyngeal Neoplasms ,030220 oncology & carcinogenesis ,Body Composition ,Carcinoma, Squamous Cell ,Female ,Oral Surgery ,business ,Biomarkers - Abstract
Low skeletal muscle mass (SMM) and sarcopenic obesity (co-presence of low SMM and obesity) are emerging prognosticators in oncology, but the prevalence and prognostic value in oropharyngeal squamous cell carcinoma (OPSCC) is not yet known.Patients with OPSCC, curative treatment intention and pre-treatment diagnostic imaging of the head and neck area were included. Patients with unknown HPV-status, palliative treatment intention or unavailable imaging were excluded, Relevant demographic and clinical characteristics were collected between 2009 and 2016. Patients were stratified into a low-, intermediate-, and high-risk group according to HPV-status, amount of pack-years, tumor and nodal stage. SMM was radiologically measured and cutoff values were determined by optimal stratification. The prognostic value of low SMM and sarcopenic obesity for overall survival (OS) and disease-free survival (DFS) was determined by Cox regression analysis and Kaplan Meier survival curves.In 216 patients, low SMM and sarcopenic obesity were present in 140 (64.8%) and 13 (6.0%) patients, respectively. On multivariate analysis, stratification into a high-risk group (HPV-negative status with ≥10-pack-years or T4-stage) was a prognostic factor for OS and DFS (HR 2.93, p 0.01) (HR 4.66, p 0.01). Of specific interest, sarcopenic obesity was a strong negative prognostic factor for OS and DFS (HR 4.42, p 0.01 and (HR 3.90, p 0.05), independent from other well-known prognostic factors such as HPV-status.Low skeletal muscle mass is highly prevalent in OPSCC patients. Sarcopenic obesity is a novel pretreatment prognosticator for OS and DFS in OPSCC and should therefore be considered in clinical decision making.
- Published
- 2019