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A nation-wide epidemiological study on the risk of developing second malignancies in patients with different histological subtypes of nasopharyngeal carcinoma
- Source :
- Oral Oncology, 56, 40-46. Elsevier Ltd., Oral Oncology, 56, 40. Elsevier Limited
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Objective: Risk assessment of second head/neck and Epstein Barr Virus (EBV)-related malignancies in patients with different nasopharyngeal carcinoma (NPC) subtypes. Methods: This is a cross-sectional study. Pathology records were retrieved from PALGA (a Dutch pathology registry database) between 1995 and 2013. Second primary malignancy (SPM) data was extracted from PALGA. Odds ratios (OR) for SPM in the head/neck, and the upper/lower airways were calculated using logistic regression. Pearson X-2-test and Fisher's exact test were used to assess the relationship between NPC (and EBV-status) with SPM. Standardized incidence rates (SIR) were calculated. Results: Histologically diagnosed NPC (keratinizing and undifferentiated and differentiated non-keratinizing subtypes) (n = 1175) were identified. NPC patients have an increased risk of second head/neck malignancies (SIR 4.7 95% CI 3.3-6.5). Keratinizing NPCs have an OR of 1.947 (95% CI 1.362-2.782) for SPM, an OR of 4.026 (95% CI 2.308-7.023) for carcinomas of the upper/lower airways, an OR of 4.306 (95% CI 2.299-8.066) for head/neck malignancies, an OR of 5.289 (95% CI 2.740-10.211) for HNSCC with a SIR of 4.7 (95CI 3.3-6.5). Non-keratinizing NPCs also have an increased risk of head/neck malignancies with a SIR of 3.2 (95% CI 1.8-5.1), but less than keratinizing NPCs (p =
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Pathology
Histology
Epidemiology
Epstein Barr Virus
Research Support
Malignancy
Database
03 medical and health sciences
0302 clinical medicine
Risk Factors
EBV
Internal medicine
Nasopharyngeal carcinoma
Journal Article
otorhinolaryngologic diseases
medicine
Humans
Non-U.S. Gov't
Netherlands
business.industry
Follow-up
Research Support, Non-U.S. Gov't
Carcinoma
Nasopharyngeal Neoplasms
Neoplasms, Second Primary
Odds ratio
Cancer registry
Second primary malignancy
medicine.disease
Head and neck squamous-cell carcinoma
stomatognathic diseases
Exact test
030104 developmental biology
030220 oncology & carcinogenesis
Oral Surgery
business
Subjects
Details
- ISSN :
- 13688375
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Oral Oncology
- Accession number :
- edsair.doi.dedup.....8a242b7bf319994efd225f717b98f69d