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The aim of this study was to explore differences in the effects of modifiable factors on oral squamous cell carcinoma (OSCC) occurring in the lower oral fissure (LOF) and upper oral fissure (UOF). We conducted a case-control study with 697 OSCC patients (119 UOF and 578 LOF) and 1910 frequency-matched controls in Fujian province, China. Data on demographic characteristics and possible modifiable factors was collected using a structured questionnaire. Unconditional logistic regression was utilized to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Alcohol drinking was more strongly associated with an increased risk of OSCC-LOF than OSCC-UOF. Tobacco smoking, the number of teeth lost ≥5, wearing denture, and recurrent oral ulceration showed similarly associations with OSCC-LOF and -UOF risk. Similarly, the beneficial effects of tea consumption, tooth-brushing ≥2times per day, high intake of fresh fish, seafood, green-leafy vegetables, other vegetables and fruits were not significantly different on OSCC-LOF and -UOF. Although most of the modifiable factors exert similar effects on both OSCC sites, this study suggests that the sites of oral cavity in LOF may be affected more by alcohol drinking than the sites in UOF. Further studies with larger samples are warranted to confirm our findings.

// Fa Chen 1, * , Tao Lin 1, * , Lingjun Yan 1 , Fengqiong Liu 1 , Jiangfeng Huang 1 , Fangping Liu 1 , Junfeng Wu 1 , Yu Qiu 2 , Lisong Lin 2 , Lin Cai 1 , Baochang He 1 1 Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fujian, China 2 Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Fujian Medical University, Fujian, China * These authors have contributed equally to this work Correspondence to: Baochang He, email: hbc517@163.com Lin Cai, email: prof_cailin@sina.com Keywords: oral cancer, fatty acid desaturase 1, fish consumption, polymorphism, case-control study Received: November 04, 2016 Accepted: January 17, 2017 Published: February 03, 2017 ABSTRACT The aim of this study was to investigate the independent and combined effects of fatty acid desaturase 1 ( FADS1 ) gene polymorphism and fish consumption on oral cancer. A hospital-based case-control study was performed including 305 oral cancer patients and 579 cancer-free controls. The genotypes were determined by TaqMan genotyping assay. Non-conditional logistic regression model was used to assess the effects of FADS1 rs174549 polymorphism and fish intake. Subjects carrying A allele of rs174549 significantly reduced the risk of oral cancer (AA VS GG, OR: 0.65, 95% CI: 0.42-0.99; AA VS AG+GG, OR: 0.67, 95% CI: 0.46-0.98). Moreover, the statistically significant reverse associations were especially evident in men, smokers, alcohol drinkers and those age ≤ 60 years. Additionally, fish intake ≥7 times/week showed a 73% reduction in risk for oral cancer compared to those who ate fish less than 2 times/week (OR: 0.27, 95% CI: 0.18-0.42). Furthermore, a significant gene-diet multiplicative interaction was observed between FADS1 rs174549 polymorphism and fish intake for oral cancer ( P =0.028). This preliminary study suggests that FADS1 rs174549 polymorphism and fish consumption may be protective factors for oral cancer, with a gene-diet multiplicative interaction. Functional studies with larger samples are required to confirm our findings.

// Fa Chen 1,2,* , Yujie Cao 3,* , Jiangfeng Huang 1,2 , Lingjun Yan 1,2 , Lisong Lin 4 , Fengqiong Liu 1,2 , Fangping Liu 1,2 , Junfeng Wu 1,2 , Yu Qiu 4 , Lin Cai 1 and Baochang He 1,2 1 Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fujian, China 2 Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fujian, China 3 Department of Stomatology, The First Affiliated Hospital of Fujian Medical University, Fujian, China 4 Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Fujian Medical University, Fujian, China * These authors have contributed equally to the work Correspondence to: Baochang He, email: // Keywords : oral squamous cell carcinoma, prognostic prediction model, prognostic index, overall survival, prospective study Received : November 30, 2016 Accepted : January 11, 2017 Published : January 26, 2017 Abstract This study aims to develop an applicable prognostic index with conventional factors for predicting outcome of patients with oral squamous cell carcinoma (OSCC). We performed a prospective study in a large cohort of 892 OSCC patients in Fujian, China. All patients were randomly divided into a discovery group and validation group. A prognostic index was developed based on β value of each significant variable obtained from the multivariate Cox regression model. The results from discovery and validation set demonstrated thatthe model-4(included clinical stage, tumor differentiation, ill-fitting denture, oral hygiene and cigarette smoking) was the optimal model. The optimal cutoff points of prognostic index (1.88 and 2.80) were determined by X-tile program which categorized all subjects into low, middle and high risk subsets. Patients in high risk group were at the greatest risk of death compared with those in low risk group (HR: 6.02; 95%CI: 4.33-8.38). Moreover, there was a significant tendency of the worse overall survival with the higher prognostic index ( P trend

This study aims to develop a simple dietary score to comprehensively evaluate the role of diet in the risk of oral cancer. A case-control study including 930 oral cancer cases and 2667 frequency-matched controls was performed in Fujian, China. Unconditional logistic regression model was used to estimate the effects of dietary factors on oral cancer. After adjustment for potential confounders, less intake of domestic meat (< 3 times per week), fish (< 3 times per week), seafood (< 3 times per week), leafy vegetables (< 1 time per day), other vegetables (< 1 time per day), fruits (< 3 times per week), milk and dairy products (< 1 time per week) and eggs (< 5 times per week) were significant risk factors for oral cancer. Then these variables were incorporated to establish dietary risk score. Assessed by the receiver operating characteristic curve, the score showed a satisfactory discriminatory capacity, with an area under the curve of 0.682 (95% CI: 0.662-0.702). Moreover, the score was positively associated with the risk of oral cancer as quartiles, and the association was apparently stronger in tobacco smokers or alcohol drinkers. Additionally, there were significant multiplicative interactions between the score and tobacco smoking or alcohol drinking for oral cancer. In the present study, a convenient dietary score with satisfactory discriminatory capacity was developed to assess the collected effect of dietary factors on oral cancer, which could provide a new strategy for the prevention of oral cancer through changing in dietary habits.

// Fa Chen 1,2,* , Lingjun Yan 1,2,* , Lisong Lin 3,* , Fengqiong Liu 1,2 , Yu Qiu 3 , Fangping Liu 1,2 , Jiangfeng Huang 1,2 , Junfeng Wu 1,2 , Lin Cai 1 , Guoxi Cai 4 , Kiyoshi Aoyagi 5 and Baochang He 1,2 1 Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fujian, China 2 Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fujian, China 3 Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Fujian Medical University, Fujian, China 4 Nagasaki Prefectural Institute of Environmental Research and Public Health, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan 5 Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan * These authors have contributed equally to the work Correspondence to: Baochang He, email: // Keywords : oral cancer, tea, milk, non-smoker, non-drinker Received : December 15, 2016 Accepted : January 24, 2017 Published : February 04, 2017 Abstract This study aims to evaluate the independent and joint effects of tea and milk consumption on oral cancer risk among non-smokers and non-drinkers (NS/ND). A hospital-based case-control study was performed in Fujian, China. 421 cases and frequency-matched 1398 controls were included without tobacco smoking and alcohol drinking habits. Unconditional logistic regression model was used to assess the relationship of tea and milk consumption with oral cancer risk. Tea and milk consumption were significantly associated with decreased risk of oral cancer, the adjusted odds ratios (aORs) were 0.73 (95% CI: 0.54-0.97) and 0.69 (95% CI: 0.55-0.88), respectively. According to subgroup analysis, the inverse associations between tea consumption and oral cancer risk were only observed among the elders (>60 years) and urban residents. While the protect effect of milk drinking was more obvious in males, normal body mass index population (18.5–23.9), urban residents and those age ≤ 60 years. Additionally, a significantly multiplicative interaction between tea and milk consumption was observed for oral cancer risk ( P = 0.001). The present study is the first to simultaneously assess the association of tea consumption and milk drinking with oral cancer risk. The results suggest that tea and milk consumption are independent protective factors for oral cancer among NS/ND, with a joint effect between them.

// Fengqiong Liu 1 , Fa Chen 1 , Jiangfeng Huang 1 , Lingjun Yan 1 , Fangping Liu 1 , Junfeng Wu 1 , Yu Qiu 2 , Xiaoyan Zheng 2 , Rongzhao Zhang 1 , Lisong Lin 2 , Baochang He 1 1 Department of Epidemiology and Health Statistic, Fujian Provincial Key Laboratory of Environment factors and Cancer, School of Public Health, Fujian Medical University, Fujian, China 2 Department of Stomatology, The First Affiliated Hospital of Fujian Medical University, Fujian, China Correspondence to: Baochang He, email: hbc517@163.com Lisong Lin, email: Dr_lsling@126.com Keywords: oral cancer, prognosis, BMI, chemotherapy, radiotherapy Received: August 01, 2016 Accepted: December 01, 2016 Published: December 09, 2016 ABSTRACT This study was performed to identify the factors affecting prognosis of oral cancer patients. 1240 pathologically confirmed oral cancer patients were included. The sociodemographic and clinical characteristics of all patients were collected. Univariate and multivariate Cox proportional hazards models were used to assess potential prognostic factors for survival. 1240 oral cancer patients were followed up for 49235.00 person months, and the 5-year overall survival rate was 64.38%. Both univariate and multivariate Cox regression analysis indicated that Body Mass Index < 18.5 kg/m 2 (vs 18.5–23.9 kg/m 2 ), age ≥ 55 years (vs < 55 years), clinical stages of II-IV (vs stage I), and poor differentiation (vs well differentiation) were associated with worse survival of oral cancer patients. While surgery (vs non-surgery) and origin of urban area (vs rural area) were protective factors. However, no significant association was found between adjuvant therapy and survival in oral cancer patients.