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A novel prognostic index for oral squamous cell carcinoma patients with surgically treated

A novel prognostic index for oral squamous cell carcinoma patients with surgically treated

Authors :
Jiangfeng Huang
Yu Qiu
Junfeng Wu
Lingjun Yan
Fa Chen
Lisong Lin
Fengqiong Liu
Yujie Cao
Lin Cai
Baochang He
Fangping Liu
Source :
Oncotarget
Publication Year :
2017
Publisher :
Impact Journals, LLC, 2017.

Abstract

// Fa Chen 1,2,* , Yujie Cao 3,* , Jiangfeng Huang 1,2 , Lingjun Yan 1,2 , Lisong Lin 4 , Fengqiong Liu 1,2 , Fangping Liu 1,2 , Junfeng Wu 1,2 , Yu Qiu 4 , Lin Cai 1 and Baochang He 1,2 1 Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fujian, China 2 Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fujian, China 3 Department of Stomatology, The First Affiliated Hospital of Fujian Medical University, Fujian, China 4 Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Fujian Medical University, Fujian, China * These authors have contributed equally to the work Correspondence to: Baochang He, email: // Keywords : oral squamous cell carcinoma, prognostic prediction model, prognostic index, overall survival, prospective study Received : November 30, 2016 Accepted : January 11, 2017 Published : January 26, 2017 Abstract This study aims to develop an applicable prognostic index with conventional factors for predicting outcome of patients with oral squamous cell carcinoma (OSCC). We performed a prospective study in a large cohort of 892 OSCC patients in Fujian, China. All patients were randomly divided into a discovery group and validation group. A prognostic index was developed based on β value of each significant variable obtained from the multivariate Cox regression model. The results from discovery and validation set demonstrated thatthe model-4(included clinical stage, tumor differentiation, ill-fitting denture, oral hygiene and cigarette smoking) was the optimal model. The optimal cutoff points of prognostic index (1.88 and 2.80) were determined by X-tile program which categorized all subjects into low, middle and high risk subsets. Patients in high risk group were at the greatest risk of death compared with those in low risk group (HR: 6.02; 95%CI: 4.33-8.38). Moreover, there was a significant tendency of the worse overall survival with the higher prognostic index ( P trend

Details

ISSN :
19492553
Volume :
8
Database :
OpenAIRE
Journal :
Oncotarget
Accession number :
edsair.doi.dedup.....cdccd1ac97afa56362d7358100fa4886
Full Text :
https://doi.org/10.18632/oncotarget.14821