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A novel prognostic index for oral squamous cell carcinoma patients with surgically treated
A novel prognostic index for oral squamous cell carcinoma patients with surgically treated
- Source :
- Oncotarget
- Publication Year :
- 2017
- Publisher :
- Impact Journals, LLC, 2017.
-
Abstract
- // Fa Chen 1,2,* , Yujie Cao 3,* , Jiangfeng Huang 1,2 , Lingjun Yan 1,2 , Lisong Lin 4 , Fengqiong Liu 1,2 , Fangping Liu 1,2 , Junfeng Wu 1,2 , Yu Qiu 4 , Lin Cai 1 and Baochang He 1,2 1 Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fujian, China 2 Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fujian, China 3 Department of Stomatology, The First Affiliated Hospital of Fujian Medical University, Fujian, China 4 Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Fujian Medical University, Fujian, China * These authors have contributed equally to the work Correspondence to: Baochang He, email: // Keywords : oral squamous cell carcinoma, prognostic prediction model, prognostic index, overall survival, prospective study Received : November 30, 2016 Accepted : January 11, 2017 Published : January 26, 2017 Abstract This study aims to develop an applicable prognostic index with conventional factors for predicting outcome of patients with oral squamous cell carcinoma (OSCC). We performed a prospective study in a large cohort of 892 OSCC patients in Fujian, China. All patients were randomly divided into a discovery group and validation group. A prognostic index was developed based on β value of each significant variable obtained from the multivariate Cox regression model. The results from discovery and validation set demonstrated thatthe model-4(included clinical stage, tumor differentiation, ill-fitting denture, oral hygiene and cigarette smoking) was the optimal model. The optimal cutoff points of prognostic index (1.88 and 2.80) were determined by X-tile program which categorized all subjects into low, middle and high risk subsets. Patients in high risk group were at the greatest risk of death compared with those in low risk group (HR: 6.02; 95%CI: 4.33-8.38). Moreover, there was a significant tendency of the worse overall survival with the higher prognostic index ( P trend
- Subjects :
- 0301 basic medicine
Gerontology
medicine.medical_specialty
overall survival
Oral hygiene
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
Epidemiology
medicine
Stage (cooking)
Prospective cohort study
business.industry
Proportional hazards model
prognostic index
oral squamous cell carcinoma
prognostic prediction model
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Cohort
Oral and maxillofacial surgery
Clinical Research Paper
business
prospective study
Subjects
Details
- ISSN :
- 19492553
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....cdccd1ac97afa56362d7358100fa4886
- Full Text :
- https://doi.org/10.18632/oncotarget.14821