142 results on '"Marcus, J."'
Search Results
2. Functional neuroimaging related to lower urinary tract sensations: Future directions for study designs and selection of patient groups: ICI‐RS 2023
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de Rijk, Mathijs M., primary, Drake, Marcus J., additional, von Gontard, Alexander, additional, Solomon, Eskinder, additional, Dmochowski, Roger, additional, Schurch, Brigitte, additional, and van Koeveringe, Gommert A., additional
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- 2023
- Full Text
- View/download PDF
3. The role of renal circadian biorhythms in lifelong LUTS
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Hervé, François, primary, Vande Walle, Johan, additional, Raes, Ann, additional, Haddad, Rebecca, additional, Monaghan, Thomas, additional, Drake, Marcus J., additional, Kamperis, Konstantinos, additional, Dossche, Lien, additional, Zipkin, Jacob, additional, Weiss, Jeffrey, additional, Verbakel, Irina, additional, Kheir, George Bou, additional, and Everaert, Karel, additional
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- 2023
- Full Text
- View/download PDF
4. Sleep Disorders, Comorbidities, Actions, Lower Urinary Tract Dysfunction, and Medications ('Sleep C.A.L.M.') in the evaluation and management of nocturia: A simple approach to a complex diagnosis
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Thomas F. Monaghan, Jeffrey P. Weiss, Alan J. Wein, Syed N. Rahman, Jason M. Lazar, Donald L. Bliwise, Karel Everaert, Gary E. Lemack, Jean‐Nicolas Cornu, Marcus J. Drake, Christopher R. Chapple, Hashim Hashim, Jerry G. Blaivas, and Roger R. Dmochowski
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Urology ,Neurology (clinical) - Published
- 2023
5. Sleep Disorders, Comorbidities, Actions, Lower Urinary Tract Dysfunction, and Medications (“Sleep C.A.L.M.”) in the evaluation and management of nocturia: A simple approach to a complex diagnosis
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Monaghan, Thomas F., primary, Weiss, Jeffrey P., additional, Wein, Alan J., additional, Rahman, Syed N., additional, Lazar, Jason M., additional, Bliwise, Donald L., additional, Everaert, Karel, additional, Lemack, Gary E., additional, Cornu, Jean‐Nicolas, additional, Drake, Marcus J., additional, Chapple, Christopher R., additional, Hashim, Hashim, additional, Blaivas, Jerry G., additional, and Dmochowski, Roger R., additional
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- 2023
- Full Text
- View/download PDF
6. Treatment decision‐making among men with lower urinary tract symptoms: A qualitative study of men's experiences with recommendations for patient‐centred practice
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Cynthia A Ochieng, Christopher R. Chapple, Lucy E Selman, Amanda L. Lewis, Marcus J. Drake, Clare Clement, Jeremy Horwood, and Paul Abrams
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Male ,medicine.medical_specialty ,Urology ,Decision Making ,030232 urology & nephrology ,Nonprobability sampling ,03 medical and health sciences ,0302 clinical medicine ,Lower Urinary Tract Symptoms ,Lower urinary tract symptoms ,medicine ,Humans ,Qualitative Research ,Aged ,Aged, 80 and over ,030219 obstetrics & reproductive medicine ,business.industry ,Symptom burden ,Patient Preference ,Middle Aged ,medicine.disease ,Nonsurgical treatment ,Family medicine ,Neurology (clinical) ,Treatment decision making ,Thematic analysis ,business ,Patient centred ,Qualitative research - Abstract
Aims To inform and guide patient-centred care for men with lower urinary tract symptoms (LUTS), by providing in-depth qualitative evidence regarding men's perspectives on treatment decision-making for LUTS. Methods An interview study of men recruited from 26 English urology departments. Purposive sampling captured surgical/nonsurgical treatment decisions, and diversity in demographics and symptom burden, in men who had urodynamics and those who did not. After diagnostic assessments, men were interviewed either pre-treatment or after LUTS surgery. Thematic analysis was conducted. Participants' descriptions of how LUTS treatment decisions were made were categorised as patient-led, doctor-led, or shared. Results A total of 41 men participated (25 pre-treatment, 16 post-surgery), ages 52-89. Twenty out of 41 described the treatment decision as shared with their consultant, 14 as doctor-led, and seven as patient-led. There was no obvious association between treatment decision-making style and patients' satisfaction with either clinicians' role in their decision or their treatment decision. Incomplete or rushed discussions and misperceptions of LUTS and its treatment were reported, indicating a risk of suboptimal decision-making support by clinicians. As well as clinician opinion, men's treatment decision-making was influenced by the results of urological assessments, comparing current symptoms with possible side-effects of surgery, and others' experiences and opinions. Conclusions Men with LUTS report and prefer different kinds of decision-making support from their clinicians, who must tailor their input to patients' preferences and needs. Patients' treatment decision-making involves multiple factors and can be challenging, and areas of inadequate clinician support were identified. Recommendations for patient-centred consultations about LUTS treatment are presented.
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- 2020
7. Assessment of patients with lower urinary tract symptoms where an undiagnosed neurological disease is suspected: A report from an International Continence Society consensus working group
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Marcus J. Drake, Evangelista Martinelli, Bilal Farhan, Sabine Klepsch, John P. Lavelle, Ricardo Pereira e Silva, Camilla Blain, Petros Georgopoulos, Jeremy Nettleton, Holly A. Roy, Catherine Dalton, Katarina Ivana Tudor, Adrian Wagg, Ailton Fernandes, Jalesh N. Panicker, Christina Anastasia Rapidi, and Ivan Radoja
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Male ,Pediatrics ,medicine.medical_specialty ,Consensus ,Neurology ,Spinal stenosis ,Urology ,030232 urology & nephrology ,03 medical and health sciences ,0302 clinical medicine ,Lower Urinary Tract Symptoms ,Normal pressure hydrocephalus ,Enuresis ,Lower urinary tract symptoms ,incontinence ,medicine ,Humans ,lower urinary tract symptoms ,Neuro-urology ,030219 obstetrics & reproductive medicine ,business.industry ,neurology ,Multiple sclerosis ,Age Factors ,Diagnostic Techniques, Urological ,neurourology ,medicine.disease ,Occult ,overactive bladder ,Overactive bladder ,Female ,Neurology (clinical) ,Nervous System Diseases ,medicine.symptom ,business - Abstract
Aim Lower urinary tract symptoms (LUTS) are a common urological referral, which sometimes can have a neurological basis in a patient with no formally diagnosed neurological disease (“occult neurology”). Early identification and specialist input is needed to avoid bad LUTS outcomes, and to initiate suitable neurological management. Methods The International Continence Society (ICS) established a neurological working group to consider;1. Which neurological conditions may include LUTS as an early feature?2. What diagnostic evaluations should be undertaken in the LUTS clinic?A shortlist of conditions was drawn up by expert consensus and discussed at the annual congress of the International Neurourology Society. A multidisciplinary working group then generated recommendations for identifying clinical features and management. Results The relevant conditions are multiple sclerosis (MS), multiple system atrophy (MSA), normal pressure hydrocephalus (NPH), early dementia, Parkinsonian syndromes (including early Parkinson’s Disease and Multiple System Atrophy) and spinal cord disorders (including spina bifida occulta with tethered cord, and spinal stenosis). In LUTS clinics, the need is to identify additional atypical features; new onset severe LUTS (excluding infection), unusual aspects (e.g. enuresis without chronic retention) or “suspicious” symptoms (e.g. numbness, weakness, speech disturbance, gait disturbance, memory loss/ cognitive impairment, and autonomic symptoms). Where occult neurology is suspected, healthcare professionals need to undertake early appropriate referral; central nervous system (CNS) imaging booked from LUTS clinic is not recommended. Conclusions Occult neurology is an uncommon underlying cause of LUTS, but it is essential to intervene promptly if suspected, and to establish suitable management pathways.
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- 2020
8. Quality control of uroflowmetry and urodynamic data from two large multicenter studies of male lower urinary tract symptoms
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Hashim Hashim, Marcus J. Drake, Joseph Jelski, Charlotte Mcdonald, J. Athene Lane, Amanda L. Lewis, Jo Worthington, Martino Aiello, Andrew Gammie, Paul Abrams, Suzanne Biers, and Christopher Harding
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Male ,Quality Control ,medicine.medical_specialty ,uroflowmetry ,Urology ,Unnecessary Surgery ,030232 urology & nephrology ,Urination ,Lower risk ,BTC (Bristol Trials Centre) ,03 medical and health sciences ,Bladder outlet obstruction ,0302 clinical medicine ,Lower Urinary Tract Symptoms ,medicine ,Humans ,Diagnostic Errors ,030219 obstetrics & reproductive medicine ,LUTS ,business.industry ,Male lower urinary tract ,UPSTREAM ,Middle Aged ,medicine.disease ,Checklist ,Urinary Bladder Neck Obstruction ,Urodynamics ,Overactive bladder ,standards ,Physical therapy ,BRTC ,overactive bladder ,Neurology (clinical) ,Societies ,business ,urodynamics - Abstract
AIM: The International Continence Society (ICS) has standardized quality control and interpretation of uroflowmetry and urodynamics. We evaluated traces from two large studies of male lower urinary tract symptoms (UPSTREAM and UNBLOCS) against ICS standards of urodynamic equipment and practice.METHODS: Ten percent of uroflowmetry and urodynamics traces were selected at random from hospital sites. A data capture template was designed from the ICS Fundamentals of Urodynamic Practice checklist. Two pretrained blinded assessors extracted the data, with a third assessor to arbitrate. Departmental records of calibration checks and equipment maintenance were scrutinized.RESULTS: Seven out of twenty-five (28%) departments reported no calibration checks. Four sites (16%) could not provide annual service records. In 32 out of 296 (10.8%) uroflowmetry traces, findings were affected by artifact. One hundred ten urodynamic study traces were reviewed; in 11 records (10%), key pressure traces were incompletely displayed. In 30 (27.2%), reference zero was not set to atmospheric pressure. Resting pressures were outside the expected range for 36 (32.7%). Pressure drift was seen in 18 traces (16.4%). At pressure-flow study commencement, permission to void was omitted in 15 (13.6%). Cough testing after voiding was done in 71.2%, but the resulting cough spikes were significantly different in 16.5%. Erroneous diagnosis of bladder outlet obstruction (BOO) was identified in six cases (5.5%).CONCLUSIONS: Erroneous diagnosis of BOO is a serious error of interpretation, as it could lead to unnecessary surgery. Other errors of standardization, testing, and interpretation were identified with lower risk of adverse implications. Inconsistent documentation of service records mean equipment accuracy is uncertain.
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- 2020
9. International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function
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Peter Petros, Alan J. Wein, Vikky Morris, Jianguo Wen, Jane Meijlink, Marco H. Blanker, Jens Christian Djurhuus, Marcus J. Drake, Hashim Hashim, and Life Course Epidemiology (LCE)
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medicine.medical_specialty ,health care personnel ,Urology ,Urinary Bladder ,030232 urology & nephrology ,Collective opinion ,decision making ,Terminology ,03 medical and health sciences ,0302 clinical medicine ,Enuresis ,Terminology as Topic ,Health care ,terminology ,medicine ,urinary tract function ,Nocturia ,Humans ,human ,Intensive care medicine ,Societies, Medical ,Urinary tract function ,standardization ,Urinary Tract Physiological Phenomena ,030219 obstetrics & reproductive medicine ,Health professionals ,business.industry ,nocturnal polyuria ,adult ,practice guideline ,continence ,article ,Clinical Practice ,publication ,Centre for Surgical Research ,Gynecology ,consensus ,enuresis ,International Continence Society ,nomenclature ,polyuria ,Neurology (clinical) ,medicine.symptom ,urethra ,business ,nocturia - Abstract
INTRODUCTION: The terminology for nocturia and nocturnal lower urinary tract function is reviewed and updated in a clinically and practically-based consensus report.METHODS: This report has been created by a Working Group under the auspices and guidelines of the International Continence Society (ICS) Standardisation Steering Committee (SSC). All relevant definitions were updated on the basis of research over the last 16 years since the publication of the first nocturia standardization document in 2002. An extensive process of 16 rounds of internal and external reviews was involved to examine each definition exhaustively, with decision-making by collective opinion (consensus).RESULTS: A clinically-based terminology report for nocturia and nocturnal lower urinary tract function, encompassing five key definitions divided into signs and symptoms has been developed. Clarity and user-friendliness have been key aims to make it interpretable by healthcare professionals and allied healthcare practitioners involved in the care of individuals with nocturnal lower urinary tract function.CONCLUSION: A consensus-based terminology report for nocturia and nocturnal lower urinary tract function has been produced to aid clinical practice and research.
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- 2019
10. Recommendations for conducting invasive urodynamics for men with lower urinary tract symptoms: Qualitative interview findings from a large randomized controlled trial (UPSTREAM)
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Marcus J. Drake, Amanda L. Lewis, Jeremy Horwood, Cynthia A Ochieng, and Lucy E Selman
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Male ,medicine.medical_specialty ,Urology ,media_common.quotation_subject ,030232 urology & nephrology ,Embarrassment ,BTC (Bristol Trials Centre) ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Clinical pathway ,Lower Urinary Tract Symptoms ,Randomized controlled trial ,Lower urinary tract symptoms ,law ,Original Clinical Article ,medicine ,Humans ,Urinary Tract ,Aged ,media_common ,Aged, 80 and over ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,LUTS ,business.industry ,Diagnostic Techniques, Urological ,Middle Aged ,transurethral resection of the prostate ,medicine.disease ,Test (assessment) ,Urodynamics ,England ,Centre for Surgical Research ,Clinical Articles ,Physical therapy ,Urodynamic testing ,BRTC ,Prostate surgery ,Neurology (clinical) ,Thematic analysis ,business - Abstract
AIMS: To capture in-depth qualitative evidence regarding attitudes to and experiences of urodynamic testing among men with lower urinary tract symptoms (LUTS) at each end of the clinical pathway.METHODS: Semi-structured interview study conducted within the Urodynamics for Prostate Surgery: Randomized Evaluation of Assessment Methods (UPSTREAM) trial, which randomized men to a care pathway including urodynamics or routine non-invasive tests from 26 secondary care urology sites across England. Men were interviewed after assessments but prior to treatment, or after surgery for LUTS. Men were purposively sampled to include those who had urodynamics and those who did not, and diversity in demographic characteristics and symptom burden. Interviews were analyzed using inductive thematic analysis.RESULTS: Forty-one men participated (25 pre-treatment, 16 post-surgery), ages 52-89. The 16 men who had not previously experienced urodynamics said they would accept the test in their assessment, but some were apprehensive or wanted more information. The 25 men who had experienced urodynamics all found it acceptable, though some reported pain, infection, or embarrassment. Embarrassment was minimized by informing patients what the procedure would be like, and ensuring privacy. Urodynamics was valued for its perceived diagnostic insight. Information deficits were reported before, during, and after the test. How and when results were explained and the adequacy of explanations varied.CONCLUSIONS: Urodynamics is acceptable to men with LUTS and generally well-tolerated. To ensure patients are prepared and informed, good communication before and during the procedure is essential. Privacy should be prioritized, and test results discussed promptly and in sufficient detail. Staff require training and guidance in these areas.
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- 2018
11. Terminology report from the International Continence Society (ICS) Working Group on Underactive Bladder (UAB)
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Victor W. Nitti, Lori A. Birder, Phillip P. Smith, Roger R. Dmochowski, Christopher R. Chapple, Paul Abrams, Gommert van Koeveringe, Marcus J. Drake, Alan J. Wein, Osamu Yamaguchi, Matthias Oelke, Nadir I. Osman, RS: MHeNs - R3 - Neuroscience, Urologie, MUMC+: MA Urologie (3), and MUMC+: MA Urologie (9)
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medicine.medical_specialty ,Urology ,STANDARDIZATION SUB-COMMITTEE ,030232 urology & nephrology ,MEDLINE ,standardisation ,Underactive bladder ,Terminology ,03 medical and health sciences ,0302 clinical medicine ,terminology ,Medicine ,Urinary tract function ,030219 obstetrics & reproductive medicine ,URINARY-TRACT FUNCTION ,DETRUSOR UNDERACTIVITY ,business.industry ,medicine.disease ,DYSFUNCTION ,lower urinary tract function ,Centre for Surgical Research ,Physical therapy ,International Continence Society ,Neurology (clinical) ,business - Abstract
[no abstract]
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- 2018
12. A commentary on expectations of healthcare professionals when applying the international continence society standards to basic assessment of lower urinary tract function
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Marcus J. Drake and Paul Abrams
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Urinary tract function ,Standardization ,Health professionals ,business.industry ,Health Personnel ,Urology ,education ,030232 urology & nephrology ,Logical approach ,Context (language use) ,Urodynamics ,03 medical and health sciences ,0302 clinical medicine ,Lower Urinary Tract Symptoms ,Nursing ,030220 oncology & carcinogenesis ,Practice Guidelines as Topic ,Humans ,Medicine ,Neurology (clinical) ,Patient group ,Societies ,business - Abstract
The International Continence Society (ICS) has sustained a drive to improve the clinical assessment of lower urinary tract function for many years. Increasingly, healthcare professionals (HCPs) engage with the guidance, and patients benefit from the precision that results when their carers apply a sensible and logical approach to assessment. The current supplementary issue of Neurourology and Urodynamics (NAU) summarizes the fundamentals derived from major ICS initiatives, emphasizing what HCPs must know when dealing with these patients, regardless of the medical discipline in which they work. It also introduces the basics of urodynamics testing to trainees and HCPs who may refer patients for testing. In this editorial review we draw out some additional points of consideration. We emphasize the need to avoid using terms in a clinical context that could imply causative mechanism, until the mechanism has actually been identified. We caution against the use of severity thresholds, until there is proper data to justify their application for any given patient group. Finally, we provide a description of the philosophical basis of urodynamics testing, including videourodynamics. This commentary should be read in the context of the other articles provided in the NAU supplement.
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- 2018
13. Fundamentals of terminology in lower urinary tract function
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Marcus J. Drake
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medicine.medical_specialty ,Urology ,Urinary system ,media_common.quotation_subject ,030232 urology & nephrology ,Urination ,Physical examination ,Underactive bladder ,Terminology ,03 medical and health sciences ,0302 clinical medicine ,Terminology as Topic ,Urinary Bladder, Underactive ,medicine ,Humans ,Nocturia ,Physical Examination ,media_common ,Urinary tract function ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,Urinary Bladder, Overactive ,business.industry ,Reference Standards ,medicine.disease ,Urodynamics ,Urinary Incontinence ,Overactive bladder ,Practice Guidelines as Topic ,Physical therapy ,Neurology (clinical) ,medicine.symptom ,business - Abstract
Aims To summarize basic definitions in the International Continence Society (ICS) Standardization of Terminology in lower urinary tract (LUT) function and their application. Methods Fundamental terminology in the ICS Standardization of Terminology LUT Function was identified and summarized. Results Evaluation of LUT requires appreciation of symptoms, signs and urodynamic observations. Symptoms are categorized according to their occurrence during the micturition cycle into storage symptoms (eg, increased daytime frequency [IDF], urgency, nocturia, or incontinence) or voiding and post-voiding symptoms (eg, slow stream or post micturition dribbling). Several problems may be present, giving rise to symptom syndromes, notably overactive bladder (during the storage phase) or underactive bladder (during the voiding phase). Signs may be derived from a bladder diary or may be elicited on physical examination. Urodynamic observations may be made by assessing flow rate, and this is combined with pressure measurement when undertaking filling cystometry and pressure flow studies. Key elements of flow and pressure measurement are described. Conclusions The review provides a succinct summary of symptoms, signs, and urodynamic observations as set out in the ICS Standard on LUT Function.
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- 2018
14. The fundamentals of chronic pelvic pain assessment, based on international continence society recommendations
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Rebecca Rinko, Melissa Dawson, Marcus J. Drake, Kristene Whitmore, and Neha Rana
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Female circumcision ,medicine.medical_specialty ,Urology ,Urinary system ,030232 urology & nephrology ,Pelvic Pain ,Terminology ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Humans ,Medicine ,Sex organ ,Societies, Medical ,Pelvis ,Pain Measurement ,Pelvic organ ,business.industry ,Pelvic pain ,Pelvic Floor ,medicine.anatomical_structure ,Practice Guidelines as Topic ,Quality of Life ,Physical therapy ,Neurology (clinical) ,Chronic Pain ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Aims Chronic pelvic pain (CPP) is defined as a noncyclical pain that has duration of at least 6 months and can lead to decreased quality of life and physical performance. The pain can be attributed to problems in the pelvic organs and/or problems in related systems, and possible psycho-social attributes may contribute to the manifestation. Due to the complex nature, CPP syndromes are multifactorial and the terminology needs to reflect the setting. Methods The current review is a synthesis of key aspects of the recent International Continence Society Standardization for Terminology in CPP Syndromes. Results Nine domains can be used for a detailed description of CPP. They include four domains specific to the pelvic organs (lower urinary tract, female genital, male genital, gastrointestinal), two related to other sources of pain which may be perceived in the pelvis (musculoskeletal, neurological) and three which may influence the response to the pain or its impact on the individual (psychological, sexual, and comorbidities). For an individual patient with CPP, each domain should be reviewed in terms of symptoms and signs, noting that positive findings could reflect either a primary cause or a secondary consequence. The findings will guide further evaluations and subsequent treatment. Conclusion We present a synthesis of the standard for terminology in CPP syndromes in women and men, which serves as a systematic framework to consider possible sources of pain (pelvic organs or other sources) and the individual responses and impact.
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- 2018
15. A critical appraisal of the principal guidelines for neurogenic lower urinary tract dysfunction using the AGREE II instrument
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Ashley Jaggi, Marcus J. Drake, Francis Fatoye, Jameel Nazir, Emad Siddiqui, and V. Giagos
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medicine.medical_specialty ,Cost-Benefit Analysis ,Urology ,Urinary system ,Nice ,Guidelines as Topic ,Health outcomes ,03 medical and health sciences ,0302 clinical medicine ,Lower Urinary Tract Symptoms ,medicine ,Humans ,Agree ii ,030212 general & internal medicine ,Urinary Bladder, Neurogenic ,Patient group ,health care economics and organizations ,computer.programming_language ,Health economics ,business.industry ,Research ,Critical appraisal ,Treatment Outcome ,Urinary Incontinence ,Physical therapy ,Research questions ,Neurology (clinical) ,business ,computer ,030217 neurology & neurosurgery - Abstract
AIMS The process of identifying research questions, synthesizing and interpreting evidence, and weight given to health economics differs between the clinical guidelines (CGs) for neurogenic lower urinary tract dysfunction (NLUTD). Consequently, the quality also varies which can have implications for clinical practice. METHODS We used the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument to assess the quality of the National Institute for Health and Care Excellent (NICE), European Association of Urology (EAU), and the International Consultations on Incontinence (ICI) CGs on neurogenic bladder. RESULTS The NICE CGs were deemed to be of the highest quality (overall score of 92%). NICE were the only guidelines to systematically incorporate cost-effectiveness research into their recommendations. The EAU CGs received an overall score of 83% and the ICI CGs achieved the lowest overall score (75%). The highest scoring domain among all the CGs was scope purpose (86%) and the lowest scoring domain was applicability (69%). All guidelines were recommended for use (mostly with some modifications). CONCLUSIONS All CGs had their inherent advantages and disadvantages, though all were still deemed to be of high quality. Incorporating cost-effectiveness research would be near impossible for guidelines with a broad-country remit. Incorporating the AGREE II instrument in the development of CGs and better collaboration between the ICI, NICE, and EAU could improve the quality, and consistency between NLUTD CGs and ultimately improve health outcomes for this important patient group.
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- 2018
16. The calculation and comparison of the Detrusor Contractility Parameter and Watts Factor
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Marcus J. Drake, Darryl Kitney, Christopher H. Fry, Andrew Gammie, and Paul Abrams
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Adult ,Male ,medicine.medical_specialty ,Urology ,Urinary Bladder ,030232 urology & nephrology ,urologic and male genital diseases ,contractility ,Wmax ,Models, Biological ,Contractility ,03 medical and health sciences ,Bladder outlet obstruction ,0302 clinical medicine ,Female patient ,Pressure ,Humans ,Medicine ,Aged ,030219 obstetrics & reproductive medicine ,Detrusor contractility ,business.industry ,Maximum flow problem ,Middle Aged ,Urinary Bladder Neck Obstruction ,Urodynamics ,Centre for Surgical Research ,bladder outlet obstruction ,Female ,Neurology (clinical) ,business ,Urine flow ,Muscle Contraction - Abstract
Aims To test the significance of association between a validated index of detrusor contractility, vCE , the Watts Factor, and the Detrusor Contractility Parameter, t20-80 ; and to test whether t20-80 depends on outflow tract resistance as indicated by Bladder Outlet Obstruction Index (BOOI). Methods Thirty-seven pressure-flow traces from 20 male and 17 female patients were analyzed and forms of the Watts Factor, t20-80 and BOOI were compared with vCE . Results The Detrusor Contractility Parameter, t20-80 , is significantly associated with vCE for both women and men without a high degree of bladder outlet obstruction. The Watts Factor only had a significant association with vCE at the point of maximum flow in women. Conclusions The Detrusor Contractility Parameter (DCP) (t20-80 ), can be measured easily from the pressure flow curves of a urodynamic test. The Watts Factor at maximum urine flow, WFQmax , can be readily calculated, but is only applicable to women. In both women and men without a high degree of bladder outlet obstruction, DCP is better associated with true detrusor contractility than any Watts Factor analysis.
- Published
- 2018
17. What research is needed to validate new urodynamic methods? ICI-RS2017
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Pierre Nelson, Andrew Gammie, Christopher Harding, Ing Goping, Marcus J. Drake, Peter F.W.M. Rosier, and Francoise Valentini
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Urologic Diseases ,medicine.medical_specialty ,Catheters ,Emerging technologies ,Urology ,Clinical Neurology ,030232 urology & nephrology ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Medical physics ,030212 general & internal medicine ,Surgical research ,research ,business.industry ,Diagnostic Techniques, Urological ,United Kingdom ,innovation ,Clinical neurology ,Test (assessment) ,Clinical trial ,Clinical Practice ,Neurology (clinical) ,business ,urodynamics - Abstract
Aims: In recent years urodynamic innovations, although well researched, have failed to follow a standardized development pathway specifically in terms of clinical trials undertaken to demonstrate efficacy. This was discussed at the International Consultation on Incontinence Research Society (ICI-RS) in Bristol, United Kingdom, 2017 with the aim of defining minimum standards for future urodynamic research. Methods: The recent recommendations from the IDEAL (innovation, development, exploration, assessment, and long-term study) collaboration regarding surgical research were reviewed. Two examples of recent novel urodynamic technologies, the penile cuff test and air charged urodynamic catheters were used as case studies and the research programmes behind their development were critiqued. Results: The rigorous and standardized model of surgical research proposed by the IDEAL collaboration was endorsed as an appropriate model for future urodynamic research. A methodical approach to research can fulfil a host of objectives including illustration of the clinical need, help with design and refinement of technique and proving efficacy for any new test or device. The penile cuff test is a novel urodynamic measurement technique that has been well researched and is now used in clinical practice. Further research is needed before air charged catheters can be recommended for widespread clinical use and the IDEAL framework provides a template for ongoing development. Conclusions: In the future, these recommendations should lead to a more standardized and uniform programme of urodynamic research and enable a thorough evaluation of new technologies prior to wider clinical uptake.
- Published
- 2018
18. Characterization of mouse neuro‐urological dynamics in a novel decerebrate arterially perfused mouse (DAPM) preparation
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Ito, Hiroki, Drake, Marcus J., Fry, Christopher H., Kanai, Anthony J., and Pickering, Anthony E.
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Decerebrate State ,Male ,Basic Science Articles ,external urethral sphincter ,Electromyography ,Original Basic Science Article ,Urinary Bladder ,Urination ,neural control, emulator, backpropagation through time ,neural control ,Mice ,Urodynamics ,Urethra ,Centre for Surgical Research ,lower urinary tract ,Journal Article ,Pressure ,Animals ,Female ,micturition ,mouse ,Anaesthesia Pain and Critical Care - Abstract
Aim: To develop the decerebrate arterially perfused mouse (DAPM) preparation, a novel voiding model of the lower urinary tract (LUT) that enables in vitro-like access with in vivo-like neural connectivity. Methods: Adult male mice were decerebrated and arterially perfused with a carbogenated, Ringer's solution to establish the DAPM. To allow distinction between central and peripheral actions of interventions, experiments were conducted in both the DAPM and in a “pithed” DAPM which has no brainstem or spinal cord control. Results: Functional micturition cycles were observed in response to bladder filling. During each void, the bladder showed strong contractions and the external urethral sphincter (EUS) showed bursting activity. Both the frequency and amplitude of non-voiding contractions (NVCs) in DAPM and putative micromotions (pMM) in pithed DAPM increased with bladder filling. Vasopressin (>400 pM) caused dyssynergy of the LUT resulting in retention in DAPM as it increased tonic EUS activity and basal bladder pressure in a dose-dependent manner (basal pressure increase also noted in pithed DAPM). Both neuromuscular blockade (vecuronium) and autonomic ganglion blockade (hexamethonium), initially caused incomplete voiding, and both drugs eventually stopped voiding in DAPM. Intravesical acetic acid (0.2%) decreased the micturition interval. Recordings from the pelvic nerve in the pithed DAPM showed bladder distention-induced activity in the non-noxious range which was associated with pMM. Conclusions: This study demonstrates the utility of the DAPM which allows a detailed characterization of LUT function in mice.
- Published
- 2018
19. An International Continence Society (ICS) report on the terminology for adult neurogenic lower urinary tract dysfunction (ANLUTD)
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Jerzy B. Gajewski, Christopher K. Payne, Marcio Augusto Averbeck, Ryuji Sakakibara, Bernard T. Haylen, Rizwan Hamid, Brigitte Schurch, Tamara Dickinson, Marcus J. Drake, and Enrico Finazzi Agrò
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medicine.medical_specialty ,Pathology ,Consensus ,Standardization ,Urology ,Urinary system ,Steering committee ,neurogenic ,030232 urology & nephrology ,Collective opinion ,Settore MED/24 - Urologia ,law.invention ,Terminology ,03 medical and health sciences ,0302 clinical medicine ,Lower Urinary Tract Symptoms ,law ,Terminology as Topic ,terminology ,Humans ,Medicine ,Urinary Bladder, Neurogenic ,Medical diagnosis ,Intensive care medicine ,Societies, Medical ,urinary tract ,dysfunction ,business.industry ,adult ,Clinical Practice ,Gynecology ,CLARITY ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Introduction The terminology for adult neurogenic lower urinary tract dysfunction (ANLUTD) should be defined and organized in a clinically based consensus Report. Methods This Report has been created by a Working Group under the auspices and guidelines of the International Continence Society (ICS) Standardization Steering Committee (SSC) assisted at intervals by external referees. All relevant definitions for ANLUTD were updated on the basis of research over the last 14 years. An extensive process of 18 rounds of internal and external review was involved to exhaustively examine each definition, with decision-making by collective opinion (consensus). Results A Terminology Report for ANLUTD, encompassing 97 definitions (42 NEW and 8 CHANGED, has been developed. It is clinically based with the most common diagnoses defined. Clarity and user-friendliness have been key aims to make it interpretable by practitioners and trainees in all the different groups involved not only in lower urinary tract dysfunction but additionally in many other medical specialties. Conclusion A consensus-based Terminology Report for ANLUTD has been produced to aid clinical practice and research.
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- 2017
20. Treatment decision‐making among men with lower urinary tract symptoms: A qualitative study of men's experiences with recommendations for patient‐centred practice
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Selman, Lucy E., primary, Clement, Clare, additional, Ochieng, Cynthia A., additional, Lewis, Amanda L., additional, Chapple, Christopher, additional, Abrams, Paul, additional, Drake, Marcus J., additional, and Horwood, Jeremy, additional
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- 2020
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21. Assessment of patients with lower urinary tract symptoms where an undiagnosed neurological disease is suspected: A report from an International Continence Society consensus working group
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Roy, Holly A., primary, Nettleton, Jeremy, additional, Blain, Camilla, additional, Dalton, Catherine, additional, Farhan, Bilal, additional, Fernandes, Ailton, additional, Georgopoulos, Petros, additional, Klepsch, Sabine, additional, Lavelle, John, additional, Martinelli, Evangelista, additional, Panicker, Jalesh N., additional, Radoja, Ivan, additional, Rapidi, Christina‐Anastasia, additional, Pereira e Silva, Ricardo, additional, Tudor, Katarina, additional, Wagg, Adrian S., additional, and Drake, Marcus J., additional
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- 2020
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22. Quality control of uroflowmetry and urodynamic data from two large multicenter studies of male lower urinary tract symptoms
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Aiello, Martino, primary, Jelski, Joseph, additional, Lewis, Amanda, additional, Worthington, Jo, additional, McDonald, Charlotte, additional, Abrams, Paul, additional, Gammie, Andrew, additional, Harding, Chris, additional, Biers, Suzanne, additional, Hashim, Hashim, additional, Lane, J. Athene, additional, and Drake, Marcus J., additional
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- 2020
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23. New targets for overactive bladder—ICI‐RS 2109
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Fry, Christopher Henry, primary, Chakrabarty, Basu, additional, Hashitani, Hikaru, additional, Andersson, Karl‐Erik, additional, McCloskey, Karen, additional, Jabr, Rita I., additional, and Drake, Marcus J., additional
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- 2019
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24. The urinary microbiome and its contribution to lower urinary tract symptoms; ICI-RS 2015
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Apostolos Apostolidis, Mohammad S. Rahnama'i, Nicola Morris, Marcus J. Drake, and Julian R. Marchesi
- Subjects
0301 basic medicine ,Microbiological culture ,business.industry ,Urology ,Urinary system ,030232 urology & nephrology ,Bacteriuria ,Disease ,medicine.disease ,Bioinformatics ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Testing protocols ,Overactive bladder ,Lower urinary tract symptoms ,Immunology ,medicine ,Neurology (clinical) ,Microbiome ,business - Abstract
Aims: The microbiome is the term used for the symbiotic microbial colonisation of healthy organs. Studies have found bacterial identifiers within voided urine which is apparently sterile on conventional laboratory culture, and accordingly there may be health and disease implications. Methods: The International Consultation on Incontinence Research Society (ICI-RS) established a literature review and expert consensus discussion focussed on the increasing awareness of the urinary microbiome, and potential research priorities. Results: The consensus considered the discrepancy between findings of conventional clinical microbiology methods, which generally rely on culture parameters predisposed towards certain ‘‘expected’’ organisms. Discrepancy between selective culture and RNA sequencing to study speciesspecific 16S ribosomal RNA is increasingly clear, and highlights the possibility that protective or harmful bacteria may be overlooked where microbiological methods are selective. There are now strong signals of the existence of a ‘‘core’’ urinary microbiome for the human urinary tract, particularly emerging with ageing. The consensus reviewed the potential relationship between a patient’s microbiome and lower urinary tract dysfunction, whether low-count bacteriuria may be clinically significant and mechanisms which could associate micro-organisms with lower urinary tract symptoms. Conclusions: Key research priorities identified include the need to establish the scope of microbiome across the range of normality and clinical presentations, and gain consensus on testing protocols. Proteomics to study enzymatic and other functions may be necessary, since different bacteria may have overlapping phenotype. Longitudinal studies into risk factors for exposure, cumulative risk, and emergence of disease need to undertaken. Neurourol. Urodynam. 36:850–853, 2017.
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- 2017
25. A standard for terminology in chronic pelvic pain syndromes: A report from the chronic pelvic pain working group of the international continence society
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Regula Doggweiler, Kristene E. Whitmore, Jane M. Meijlink, Marcus J. Drake, Helena Frawley, Jørgen Nordling, Philip Hanno, Matthew O. Fraser, Yukio Homma, Gustavo Garrido, Mario J. Gomes, Sohier Elneil, Joop P. van de Merwe, Alex T.L. Lin, and Hikaru Tomoe
- Subjects
Musculoskeletal pain ,medicine.medical_specialty ,030219 obstetrics & reproductive medicine ,Central sensitization ,business.industry ,Urology ,Pelvic pain ,030232 urology & nephrology ,body regions ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Unnecessary Procedure ,medicine ,Etiology ,Physical therapy ,Neurology (clinical) ,medicine.symptom ,business ,Primary problem ,Pelvis - Abstract
Chronic pelvic pain (CPP) presents an etiology that is often unknown, difficult to classify and multifactorial, which leads to difficult therapeutic management. The symptoms often suggest dysfunction of one or more systems in the pelvis, accompanied by negative consequences from a cognitive, behavioral, sexual and emotional point of view, with a significant impact on the quality of life. In a patient with CPP, there are many factors involved, a number of different pathologies or phenomena of peripheral and central sensitization, so it is recommended to initially focus the study on the location and characteristics of the pain, without ruling out the study of other organs, Hence the importance of an interdisciplinary and multidisciplinary approach for a correct diagnosis and treatment. Myofascial pelvic pain should be considered in all women who consult for pelvic pain. Musculoskeletal changes may be related to CPP, either as the primary problem or as a secondary reaction to pelvic pain. The importance of musculoskeletal pain is often underestimated. Considering myofascial syndrome early in the management of pelvic pain may prevent the performance of certain unnecessary procedures.
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- 2016
26. Estimation of bladder contractility from intravesical pressure-volume measurements
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Christopher H. Fry, Andrew Gammie, Bahareh Vahabi, Marcus J. Drake, Darryl Kitney, and Paul Abrams
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medicine.medical_specialty ,Urology ,media_common.quotation_subject ,030232 urology & nephrology ,urologic and male genital diseases ,Urination ,Contractility ,03 medical and health sciences ,0302 clinical medicine ,Intravesical pressure ,Internal medicine ,Medicine ,Isovolumetric contraction ,media_common ,Urinary bladder ,business.industry ,Volume measurements ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Anesthesia ,Bladder contractility ,Cardiology ,Neurology (clinical) ,medicine.symptom ,business ,Muscle contraction - Abstract
© 2016 Wiley Periodicals, Inc. Aims: To describe parameters from urodynamic pressure recordings that describe urinary bladder contractility through the use of principles of muscle mechanics. Methods: Subtracted detrusor pressure and voided flow were recorded from patients undergoing filling cystometry. The isovolumetric increase of detrusor pressure, P, of a voluntary bladder contraction before voiding was used to generate a plot of (dP/dt)/P versus P. Extrapolation of the plot to the y-axis and the x-axis generated a contractility parameter, vCE (the maximum rate of pressure development) and the maximum isovolumetric pressure, P0, respectively. Similar curves were obtained in ex vivo pig bladders with different concentrations of the inotropic agent carbachol and shown in a supplement. Results: Values of vCE, but not P0, diminished with age in female subjects. vCE was most significantly associated with the 20–80% duration of isovolumetric contraction t20–80; and a weaker association with maximum flow rate and BCI in women. P0 was not associated with any urodynamic variable in women, but in men was with t20–80 and isovolumetric pressure indices. Conclusions: The rate of isovolumetric subtracted detrusor pressure (t20–80) increase shows a very significant association with indices of bladder contractility as derived from a derived force–velocity curve. We propose that t20–80 is a detrusor contractility parameter (DCP). Neurourol. Urodynam. 36:1009–1014, 2017. © 2016 Wiley Periodicals, Inc.
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- 2016
27. Neurogenic lower urinary tract dysfunction: Clinical management recommendations of the Neurologic Incontinence committee of the fifth International Consultation on Incontinence 2013
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John Heesakkers, Apostolos Apostolidis, Anton Emmanuel, S C W Harrison, Jean-Jacques Wyndaele, Jalesh N. Panicker, Gary E. Lemack, Marcus J. Drake, Helmut Madersbacher, Andrea Cocci, Piotr Radziszewski, Ryuji Sakakibara, and Jerzy B. Gajewski
- Subjects
medicine.medical_specialty ,Evidence-based practice ,business.industry ,Urology ,030232 urology & nephrology ,Bowel management ,Urinary incontinence ,Context (language use) ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,Overactive bladder ,Neurogenic Bowel ,Lower urinary tract symptoms ,Physical therapy ,Medicine ,Neurology (clinical) ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
BACKGROUND: Evidence-based guidelines for the management of neurological disease and lower bowel dysfunction have been produced by the International Consultations on Incontinence (ICI). These are comprehensive guidelines, and were developed to have world-wide relevance. AIMS: To update clinical management of neurogenic bowel dysfunction from the recommendations of the 4th ICI, 2009. MATERIALS AND METHODS: A series of evidence reviews and updates were performed by members of the working group. The resulting guidelines were presented at the 2012 meeting of the European Association of Urology for consultation, and modifications applied to deliver evidence based conclusions and recommendations for the scientific report of the 5th edition of the ICI in 2013. RESULTS: The current review is a synthesis of the conclusions and recommendations, including the algorithms for initial and specialized management of neurogenic bowel dysfunction. The pathophysiology is described in terms of spinal cord injury, multiple sclerosis, and Parkinson's disease. Assessment requires detailed history and clinical assessment, general investigations, and specialized testing, if required. Treatment primarily focuses on optimizing stool consistency and regulating bowel evacuation to improve quality of life. Symptom management covers conservative and interventional measures to promote good habits and assist stool evacuation, along with prevention of incontinence. Education is essential to achieving optimal bowel management. DISCUSSION: The review offers a pragmatic approach to management in the context of complex pathophysiology and varied evidence base.
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- 2016
28. Risk factors and functional abnormalities associated with adult onset secondary nocturnal enuresis in women
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Marcus J. Drake, Chendrimada Madhu, Doyo Gragn Enki, and Hashim Hashim
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medicine.medical_specialty ,Stress incontinence ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,business.industry ,Urology ,030232 urology & nephrology ,Urinary incontinence ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Overactive bladder ,Lower urinary tract symptoms ,Internal medicine ,Medicine ,Urodynamic testing ,Nocturia ,Neurology (clinical) ,Age of onset ,medicine.symptom ,business ,Body mass index - Abstract
Aims The study aims to evaluate bothersome lower urinary tract symptoms (LUTS), risk factors, and associated functional abnormalities in women reporting adult onset secondary nocturnal enuresis (SNE), to help understand factors associated with SNE. Methods 12,795 women (age >18) attending a tertiary referral centre underwent a comprehensive standardized evaluation including urodynamic testing in accordance with the International Continence Society recommendations. Records of all patients reporting bedwetting while asleep were evaluated under various categories. Multiple logistic regression was used to identify statistically significant risk factors and urodynamic findings associated with SNE. Results The prevalence of SNE in women undergoing urodynamic testing for bothersome LUTS was 14.4% (1,838). High BMI (OR = 1.47, P
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- 2015
29. International Continence Society consensus on the diagnosis and treatment of nocturia
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Hashim Hashim, François Hervé, Philip Van Kerrebroeck, Ruud Bosch, Alan J. Wein, Christopher R. Chapple, Marcus J. Drake, Sherif Mourad, Paul Abrams, Roger R. Dmochowski, Karel Everaert, RS: MHeNs - R3 - Neuroscience, MUMC+: MA Urologie (9), and Urologie
- Subjects
Male ,desmopressin ,DIURNAL-VARIATION ,030232 urology & nephrology ,0302 clinical medicine ,Delphi technique ,Deamino Arginine Vasopressin ,GENDER-DIFFERENCE ,Desmopressin ,ALL-CAUSE MORTALITY ,030219 obstetrics & reproductive medicine ,Antidiuretic Agents ,Middle Aged ,expert opinion ,Centre for Surgical Research ,interdisciplinary research ,Female ,Nocturia ,medicine.symptom ,Hyponatremia ,guideline ,nocturia ,medicine.drug ,Adult ,medicine.medical_specialty ,SEX-DIFFERENCES ,Consensus ,Urology ,DISINTEGRATING TABLET ,03 medical and health sciences ,Polyuria ,POLYURIA ,medicine ,Humans ,Medical history ,Intensive care medicine ,Life Style ,Aged ,SERUM SODIUM ,business.industry ,nocturnal polyuria ,URINARY-TRACT SYMPTOMS ,Guideline ,medicine.disease ,Obstructive sleep apnea ,Sleep deprivation ,Urodynamics ,Neurology (clinical) ,business ,Societies ,SLEEP-DEPRIVATION - Abstract
Introduction: Patients with nocturia have to face many hurdles before being diagnosed and treated properly. The aim of this paper is to: summarize the nocturia patient pathway, explore how nocturia is diagnosed and treated in the real world and use the Delphi method to develop a practical algorithm with a focus on what steps need to be taken before prescribing desmopressin. Methods: Evidence comes from existing guidelines (Google, PubMed), International Consultation on Incontinence-Research Society (ICI-RS) 2017, prescribing information and a Delphi panel (3 rounds). The International Continence Society initiated this study, the authors represent the ICI-RS, European Association of Urology, and Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction (SUFU). Results: Diagnostic packages: consensus on, history taking for all causalities, intake diary (fluid, food) and bladder diary, not for its duration. Pelvic (women) or rectal (men) examination, prostate-specific antigen, serum sodium check (SSC), renal function, endocrine screening: when judged necessary. Timing or empty stomach when SSC is not important. Therapeutic packages: the safe candidates for desmopressin can be phenotyped as no polydipsia, heart/kidney failure, severe leg edema or obstructive sleep apnea syndrome. Lifestyle interventions may be useful. Initiating desmopressin: risk management consensus on three clinical pictures. Follow-up of desmopressin therapy: there was consensus on SSC day 3 to 7, and at 1 month. Stop therapy if SSC is
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- 2018
30. Why ICS standardization of lower urinary tract symptoms matters
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Dirk De Ridder and Marcus J. Drake
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JOINT REPORT ,medicine.medical_specialty ,Science & Technology ,030219 obstetrics & reproductive medicine ,Standardization ,business.industry ,Urology ,030232 urology & nephrology ,MEDLINE ,Urology & Nephrology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,PELVIC FLOOR DYSFUNCTION ,Lower urinary tract symptoms ,Internal medicine ,medicine ,TERMINOLOGY ,Neurology (clinical) ,business ,Life Sciences & Biomedicine - Abstract
Notice of Withdrawal: Why ICS standardization of lower urinary tract symptoms matters by Dirk De Ridder and Marcus Drake The Editorial Comment "Why ICS standardization of lower urinary tract symptoms matters" published online 28 June 2018 in Wiley Online Library (wileyonlinelibrary.com), has been temporarily withdrawn by agreement between the journal editorial office and Wiley Periodicals, Inc. The withdrawal has been agreed because the article will publish in final form in the Neurourology and Urodynamics special issue, Fundamental Assessment of Lower Urinary Tract Dysfunction, that will publish in August 2018. ispartof: NEUROUROLOGY AND URODYNAMICS vol:37 issue:S6 pages:S67-S68 ispartof: location:United States status: published
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- 2018
31. Basic concepts in nocturia, based on international continence society standards in nocturnal lower urinary tract function
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Hashim Hashim and Marcus J. Drake
- Subjects
medicine.medical_specialty ,Urology ,Urinary system ,Urinary Bladder ,030232 urology & nephrology ,Urine ,Nocturnal ,urologic and male genital diseases ,03 medical and health sciences ,0302 clinical medicine ,Polyuria ,Enuresis ,medicine ,Nocturia ,Humans ,Intensive care medicine ,Urinary tract function ,Sleep disorder ,business.industry ,medicine.disease ,female genital diseases and pregnancy complications ,Urodynamics ,030220 oncology & carcinogenesis ,Practice Guidelines as Topic ,Neurology (clinical) ,medicine.symptom ,business ,Societies - Abstract
Aims To review the recommendations on nocturia in the International Continence Society (ICS) Standardization documents, setting out key definitions and parameters for use in clinical practice. Methods Definitions and evaluations described in the ICS Standards on Nocturia and Terminology for Lower Urinary Tract Function were identified and summarized. Results The terms have been divided into signs and symptoms. Nocturia as a symptom is waking at night to pass urine and as a sign is the number of times an individual passes urine during their main sleep period. Nocturnal polyuria as a symptom is passing large volumes of urine at night and as a sign is the excessive production of urine during the individual's main sleep period. These should be quantified using a 3-day bladder diary, thereby facilitating identification of 24-h polyuria, nocturnal polyuria, lower urinary tract dysfunction, or sleep disorder. Conclusions The summary reflects the multifactorial influences in nocturia and provides a pragmatic insight into bladder diary analysis for deriving key parameters relevant to clinical therapy.
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- 2018
32. Neurological lower urinary tract dysfunction essential terminology
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Jerzy B. Gajewski and Marcus J. Drake
- Subjects
medicine.medical_specialty ,Urology ,Urinary system ,Population ,030232 urology & nephrology ,Physical examination ,Urinary incontinence ,Disease ,03 medical and health sciences ,Bladder outlet obstruction ,0302 clinical medicine ,Lower Urinary Tract Symptoms ,Urethra ,Terminology as Topic ,Sensation ,medicine ,Humans ,Urinary Bladder, Neurogenic ,education ,Incontinence ,education.field_of_study ,medicine.diagnostic_test ,LUTS ,business.industry ,Cauda equina ,Urodynamics ,medicine.anatomical_structure ,Centre for Surgical Research ,Practice Guidelines as Topic ,Standardisation ,Neurology (clinical) ,medicine.symptom ,business ,Neurological disease ,030217 neurology & neurosurgery - Abstract
AIMS: To introduce basic concepts and definitions in the International Continence Society (ICS) Standardisation of Terminology in adult Neurogenic Lower Urinary Tract Dysfunction (NLUTD).METHODS: Fundamental terminology in the ICS Standardisation of Terminology of Adult NLUTD was identified and summarised.RESULTS: NLUTD is often associated with impairment of cognitive, motor, sensory and/or autonomic functions. Lesions are categorised into suprapontine, pontine/ suprasacral spinal, sacral spinal, cauda equina/ peripheral nerve or mixed lesions. People affected with neurological disease are also at risk of the conditions seen in the general population, such as benign prostate enlargement. Symptoms of NLUTD include alterations in bladder or urethral sensation and incontinence. Loss of urine can result from incontinence, involuntary passing of urine and factors that impair toilet use, incorporating problems such as impaired cognition urinary incontinence, impaired mobility urinary incontinence and voiding dysregulation. Signs may be discerned by physical examination and recording of a frequency volume chart or bladder diary. Urodynamic observations during filling cystometry may include altered sensations, neurogenic detrusor overactivity and reduced bladder compliance. During pressure flow studies, there may be detrusor underactivity or bladder outlet obstruction (BOO). BOO may be caused by various forms poorly co-ordinated muscle activity in the bladder outlet. Symptoms, signs and urodynamic observations may be useful in diagnosing the presence and specific location of neurological impairment.CONCLUSIONS: The review provides a succinct summary of symptoms, signs and urodynamic observations as set out in the ICS Standard on Adult NLUTD.
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- 2018
33. How to use the Pelvic Organ Prolapse Quantification (POP-Q) system?
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Chendrimada Madhu, Steven Swift, Sophie Moloney-Geany, and Marcus J. Drake
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medicine.medical_specialty ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,Perineum ,Pelvic Organ Prolapse ,Urogynecology ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Sex organ ,Stage (cooking) ,Cervix ,Pelvic organ ,030219 obstetrics & reproductive medicine ,Hysterectomy ,business.industry ,Pelvic Floor ,Clinical Practice ,medicine.anatomical_structure ,Vagina ,Female ,Neurology (clinical) ,Radiology ,business - Abstract
Aims To set out the basic description of pelvic organ prolapse (POP) using the International Continence Society/International Urogynecology Association Pelvic Organ Prolapse Quantification (POP-Q) system. Methods The basic approach to use of the POP-Q was identified and summarized. Results Six defined points in the vagina are identified; points Aa and Ba for the anterior vagina, Ap and Bp for the posterior vagina, and C and D for the cervix/vault. Point D is not used in women who previously had a hysterectomy. The patient is asked to strain, ideally when in the standing position, to elicit the POP to its maximum extent. The location of the defined points is then gauged relative to the hymenal ring and recorded on a grid. Three additional measurements are taken to achieve a full description; the genital hiatus length, perineal body length, and total vaginal length. Staging a POP relies on identifying the lowest extent of any part of the six defined points; if any point reaches close to the hymenal ring (at least stage 2), the prolapse is usually symptomatic. Conclusions The POP-Q system is readily cataloged and offers detailed description of considerable benefit in clinical practice and research.
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- 2018
34. The fundamentals of uroflowmetry practice, based on International Continence Society good urodynamic practices recommendations
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Andrew Gammie and Marcus J. Drake
- Subjects
03 medical and health sciences ,Urodynamics ,030219 obstetrics & reproductive medicine ,0302 clinical medicine ,Urology ,Practice Guidelines as Topic ,Urinary Bladder ,030232 urology & nephrology ,Humans ,Urination ,Diagnostic Techniques, Urological ,Neurology (clinical) ,Societies - Abstract
To review the recommendations on uroflowmetry in the International Continence Society (ICS) Standardization documents in order to identify a systematic approach to the delivery and interpretation of free flow rate testing in clinical practice.Expectations of service and good practice in uroflowmetry described in the ICS standards on Urodynamic Practice, Urodynamic Equipment, and Terminology for Lower Urinary Tract Function were identified and summarized.Urodynamic centers should provide a suitable uroflowmetry testing environment. Equipment should be calibrated and maintained according to manufacturer requirements. Patients should be well-informed in advance of the test. They should be advised to avoid: knocking the machine; allowing the stream to move; squeezing the urethra; and body movements. It is generally appropriate to get more than one flow trace for each patient. Voided volume should be representative for the patient, for example by comparing with values recorded on a Bladder Diary. Post void residual (PVR) should be measured soon after testing. After the test, the urodynamicist should review the trace and ensure maximum flow rate and end of micturition are correctly identified in case the equipment has inappropriately taken the values from a trace artefact.The summary provides a systematic approach to ensure a representative, high quality, non-invasive flow test is carried out for individual patients.
- Published
- 2018
35. Fundamentals of urodynamic practice, based on International Continence Society good urodynamic practices recommendations
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Hashim Hashim, Marcus J. Drake, Stergios K. Doumouchtsis, and Andrew Gammie
- Subjects
medicine.medical_specialty ,Standardization ,Urology ,Urinary Bladder ,030232 urology & nephrology ,Urination ,Terminology ,03 medical and health sciences ,0302 clinical medicine ,Chart ,Clinical history ,Medicine ,Humans ,Medical physics ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,business.industry ,Cystometry ,Diagnostic Techniques, Urological ,Clinical Practice ,Urodynamics ,Practice Guidelines as Topic ,Urodynamic testing ,Neurology (clinical) ,business ,Societies - Abstract
Aims To review the recommendations on basic urodynamic testing in the International Continence Society (ICS) standardization documents, specifying key recommendations for delivery and interpretation in clinical practice. Methods Fundamental expectations described in the ICS standards on good urodynamic practices, urodynamic equipment, and terminology for lower urinary tract (LUT) function were identified and summarized. Results The ICS standard urodynamic protocol includes clinical history, including symptom and bother score(s), examination, 3-day voiding chart/diary, representative uroflowmetry with post-void residual, and cystometry with pressure-flow study (PFS). Liquid filled catheters are connected to pressure transducers at the same vertical pressure as the patient's pubic symphysis, taking atmospheric pressure as the zero value. Urodynamic testing is done to answer specific therapy-driven questions for treatment selection; provocations are applied to give the best chance of reproducing the problem during the test. Quality of recording is monitored throughout, and remedial steps taken for any technical issues occurring during testing. Labels are applied during the test to document events, such as patient-reported sensation, provocation tests, and permission to void. After the test, the pressure and flow traces are scrutinized to ensure artefacts do not confound the findings. An ICS standard urodynamic report details the key aspects, reporting clinical observations, technical, and quality issues. Urodynamic services must maintain and calibrate equipment according to manufacturer stipulations. Conclusions The review provides a succinct summary of practice expectations for a urodynamic unit offering cystometry and pressure flow studies (PFS) to an appropriate standard.
- Published
- 2018
36. Drug utilization patterns and healthcare resource use and costs in patients with neurogenic bladder in the United Kingdom: A retrospective primary care database study
- Author
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Jaggi, Ashley, primary, Nazir, Jameel, additional, Fatoye, Francis, additional, Siddiqui, Emad, additional, Choudhury, Nurul, additional, Argoubi, Ramzi, additional, Ali, Mahmood, additional, Ridder, Dirk, additional, and Drake, Marcus J., additional
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- 2019
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37. International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function
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Hashim, Hashim, primary, Blanker, Marco H., additional, Drake, Marcus J., additional, Djurhuus, Jens Christian, additional, Meijlink, Jane, additional, Morris, Vikky, additional, Petros, Peter, additional, Wen, Jian Guo, additional, and Wein, Alan, additional
- Published
- 2019
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38. Targeting p75 neurotrophin receptors ameliorates spinal cord injury-induced detrusor sphincter dyssynergia in mice
- Author
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Christopher H. Fry, Samuel Getchell, Evan J. Carder, Naoki Yoshimura, Irina Zabbarova, Khalifa Almansoori, Youko Ikeda, Lori A. Birder, Pradeep Tyagi, Anthony Kanai, Marcus J. Drake, Amanda Wolf-Johnston, and Peter Wipf
- Subjects
Neurogenic bladder dysfunction ,0301 basic medicine ,medicine.medical_specialty ,Urology ,Urinary system ,Morpholines ,Receptor, Nerve Growth Factor ,Article ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Lower Urinary Tract Symptoms ,Urethra ,medicine ,Animals ,Neurodegeneration ,Isoleucine ,Spinal cord injury ,Spinal Cord Injuries ,biology ,business.industry ,Electromyography ,Urinary Bladder, Overactive ,Urethral sphincter ,Urinary Bladder Diseases ,LM11A-31 ,medicine.disease ,Spinal cord ,Pathophysiology ,030104 developmental biology ,medicine.anatomical_structure ,Centre for Surgical Research ,Lower urinary tract dysfunction/symptoms (LUTD/LUTS) ,Proneurotrophins ,biology.protein ,Neurology (clinical) ,Detrusor sphincter dyssynergia ,business ,030217 neurology & neurosurgery ,Neurotrophin - Abstract
Aims: To determine the role of p75 neurotrophin receptor (p75NTR) and the therapeutic effect of the selective small molecule p75NTR modulator, LM11A-31, in spinal cord injury (SCI) induced lower urinary tract dysfunction (LTUD) using a mouse model. Methods: Adult female T8-T9 transected mice were gavaged daily with LM11A-31 (100mg/kg) for up to 6 weeks, starting 1 day before, or 7 days following injury. Mice were evaluated in vivo using urine spot analysis, cystometrograms (CMGs), and external urethral sphincter (EUS) electromyograms (EMGs); and in vitro using histology, immunohistochemistry, and Western blot. Results: Our studies confirm highest expression of p75NTRs in the detrusor layer of the mouse bladder and lamina II region of the dorsal horn of the lumbar-sacral (L6-S1) spinal cord which significantly decreased following SCI. LM11A-31 prevented or ameliorated the detrusor sphincter dyssynergia (DSD) and detrusor overactivity (DO) in SCI mice, significantly improving bladder compliance. Furthermore, LM11A-31 treatment blocked the SCI-related urothelial damage and bladder wall remodeling. Conclusion: Drugs targeting p75NTRs can moderate DSD and DO in SCI mice, may identify pathophysiological mechanisms, and have therapeutic potential in SCI patients.
- Published
- 2017
39. Efficacy and safety of artificial urinary sphincter (AUS): Results of a large multi‐institutional cohort of patients with mid‐term follow‐up
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Tutolo, Manuela, primary, Cornu, Jean‐Nicolas, additional, Bauer, Ricarda M., additional, Ahyai, Sascha, additional, Bozzini, Giorgio, additional, Heesakkers, John, additional, Drake, Marcus J., additional, Tikkinen, Kari A.O., additional, Launonen, Ene, additional, Larré, Stéphane, additional, Thiruchelvam, Nikesh, additional, Lee, Richard, additional, Li, Philip, additional, Favro, Michele, additional, Zaffuto, Emanuele, additional, Bachmann, Alexander, additional, Martinez‐Salamanca, Juan I., additional, Pichon, Thomas, additional, De Nunzio, Cosimo, additional, Ammirati, Enrico, additional, Haab, Francois, additional, and Van Der Aa, Frank, additional
- Published
- 2018
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40. Recommendations for conducting invasive urodynamics for men with lower urinary tract symptoms: Qualitative interview findings from a large randomized controlled trial (UPSTREAM)
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Selman, Lucy E., primary, Ochieng, Cynthia A., additional, Lewis, Amanda L., additional, Drake, Marcus J., additional, and Horwood, Jeremy, additional
- Published
- 2018
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41. Does altered myogenic activity contribute to OAB symptoms from detrusor overactivity? ICI-RS 2013
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Eduardo Cortes, Christopher H. Fry, Sam Chacko, and Marcus J. Drake
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Detrusor muscle ,medicine.medical_specialty ,business.industry ,Urology ,Myogenic contraction ,Urinary system ,urologic and male genital diseases ,Contractile protein ,Wall stress ,Intravesical pressure ,medicine.anatomical_structure ,Endocrinology ,Internal medicine ,medicine ,Spontaneous contraction ,Myocyte ,Neurology (clinical) ,business - Abstract
Aims To highlight novel experimental approaches that test if the Myogenic Hypothesis remains viable as a contributor to the aetiology of detrusor overactivity. Methods To summarise the conclusions of a workshop held under the auspices of ICI-RS in 2013. Results Several theories may explain the pathology of detrusor overactivity and include a myogenic theory with fundamental changes to detrusor muscle excitation-contraction coupling. The isolated bladder displays micromotions that do not normally translate into significant changes of intravesical pressure. However, their amplitude and frequency are altered in animal models of bladder dysfunction. The origin of micromotions, if they generate significant changes of intravesical pressure and contribute to urinary tract sensations remain unanswered. Within the myocyte, changes to contractile protein phosphorylation through accessory proteins and cytoplasmic regulatory pathways occur in lower urinary tract pathologies associated with detrusor overactivity. Furthermore, myocytes isolated from overactive human bladders generate greater spontaneous activity, but a complete description of changes to ionic currents remains to be characterised. Finally, several growth factors, including mechano-growth factor, are released when bladder wall stress is increased, as with outflow obstruction. However the phenotype of the transformed detrusor myocytes remains to be measured. Conclusions A number of lines of evidence suggest that the Myogenic Hypothesis remains viable as a contributor to detrusor overactivity. Neurourol. Urodynam. 33:577–580, 2014. © 2014 Wiley Periodicals, Inc.
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- 2014
42. Terminology report from the International Continence Society (ICS) Working Group on Underactive Bladder (UAB)
- Author
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Chapple, Christopher R., primary, Osman, Nadir I., additional, Birder, Lori, additional, Dmochowski, Roger, additional, Drake, Marcus J., additional, van Koeveringe, Gommert, additional, Nitti, Victor W., additional, Oelke, Matthias, additional, Smith, Phillip P., additional, Yamaguchi, Osamu, additional, Wein, Alan, additional, and Abrams, Paul, additional
- Published
- 2018
- Full Text
- View/download PDF
43. The fundamentals of uroflowmetry practice, based on International Continence Society good urodynamic practices recommendations
- Author
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Gammie, Andrew, primary and Drake, Marcus J., additional
- Published
- 2018
- Full Text
- View/download PDF
44. Fundamentals of terminology in lower urinary tract function
- Author
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Drake, Marcus J., primary
- Published
- 2018
- Full Text
- View/download PDF
45. Fundamentals of urodynamic practice, based on International Continence Society good urodynamic practices recommendations
- Author
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Drake, Marcus J., primary, Doumouchtsis, Stergios K., additional, Hashim, Hashim, additional, and Gammie, Andrew, additional
- Published
- 2018
- Full Text
- View/download PDF
46. A commentary on expectations of healthcare professionals when applying the international continence society standards to basic assessment of lower urinary tract function
- Author
-
Drake, Marcus J., primary and Abrams, Paul, additional
- Published
- 2018
- Full Text
- View/download PDF
47. How to use the Pelvic Organ Prolapse Quantification (POP-Q) system?
- Author
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Madhu, Chendrimada, primary, Swift, Steven, additional, Moloney-Geany, Sophie, additional, and Drake, Marcus J., additional
- Published
- 2018
- Full Text
- View/download PDF
48. The fundamentals of chronic pelvic pain assessment, based on international continence society recommendations
- Author
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Rana, Neha, primary, Drake, Marcus J., additional, Rinko, Rebecca, additional, Dawson, Melissa, additional, and Whitmore, Kristene E., additional
- Published
- 2018
- Full Text
- View/download PDF
49. Neurological lower urinary tract dysfunction essential terminology
- Author
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Gajewski, Jerzy B., primary and Drake, Marcus J., additional
- Published
- 2018
- Full Text
- View/download PDF
50. What research is needed to validate new urodynamic methods? ICI-RS2017
- Author
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Harding, Christopher, primary, Rosier, Peter F.W.M., additional, Drake, Marcus J., additional, Valentini, Francoise, additional, Nelson, Pierre P., additional, Goping, Ing, additional, and Gammie, Andrew, additional
- Published
- 2018
- Full Text
- View/download PDF
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