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Estimation of bladder contractility from intravesical pressure-volume measurements
- Source :
- Neurourology and Urodynamics. 36:1009-1014
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- © 2016 Wiley Periodicals, Inc. Aims: To describe parameters from urodynamic pressure recordings that describe urinary bladder contractility through the use of principles of muscle mechanics. Methods: Subtracted detrusor pressure and voided flow were recorded from patients undergoing filling cystometry. The isovolumetric increase of detrusor pressure, P, of a voluntary bladder contraction before voiding was used to generate a plot of (dP/dt)/P versus P. Extrapolation of the plot to the y-axis and the x-axis generated a contractility parameter, vCE (the maximum rate of pressure development) and the maximum isovolumetric pressure, P0, respectively. Similar curves were obtained in ex vivo pig bladders with different concentrations of the inotropic agent carbachol and shown in a supplement. Results: Values of vCE, but not P0, diminished with age in female subjects. vCE was most significantly associated with the 20–80% duration of isovolumetric contraction t20–80; and a weaker association with maximum flow rate and BCI in women. P0 was not associated with any urodynamic variable in women, but in men was with t20–80 and isovolumetric pressure indices. Conclusions: The rate of isovolumetric subtracted detrusor pressure (t20–80) increase shows a very significant association with indices of bladder contractility as derived from a derived force–velocity curve. We propose that t20–80 is a detrusor contractility parameter (DCP). Neurourol. Urodynam. 36:1009–1014, 2017. © 2016 Wiley Periodicals, Inc.
- Subjects :
- medicine.medical_specialty
Urology
media_common.quotation_subject
030232 urology & nephrology
urologic and male genital diseases
Urination
Contractility
03 medical and health sciences
0302 clinical medicine
Intravesical pressure
Internal medicine
Medicine
Isovolumetric contraction
media_common
Urinary bladder
business.industry
Volume measurements
medicine.anatomical_structure
030220 oncology & carcinogenesis
Anesthesia
Bladder contractility
Cardiology
Neurology (clinical)
medicine.symptom
business
Muscle contraction
Subjects
Details
- ISSN :
- 07332467
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Neurourology and Urodynamics
- Accession number :
- edsair.doi...........68542a2468e9579cab9169cbf44529b0