1. Divergent brain network connectivity in amyotrophic lateral sclerosis
- Author
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Federica Agosta, Elisa Canu, Paola Valsasina, Giancarlo Comi, Massimo Filippi, Nilo Riva, Alessandro Prelle, Agosta, F, Canu, E, Valsasina, P, Riva, N, Prelle, A, Comi, G, and Filippi, M
- Subjects
Adult ,Male ,Aging ,Posterior parietal cortex ,Neuropsychological Tests ,Brain mapping ,Executive Function ,medicine ,Humans ,Neuropsychological assessment ,Default mode network ,Aged ,Brain Mapping ,medicine.diagnostic_test ,Resting state fMRI ,General Neuroscience ,Amyotrophic Lateral Sclerosis ,Brain ,Middle Aged ,Executive functions ,Magnetic Resonance Imaging ,Female ,Orbitofrontal cortex ,Neurology (clinical) ,Nerve Net ,Geriatrics and Gerontology ,Psychology ,Functional magnetic resonance imaging ,Neuroscience ,Developmental Biology - Abstract
"Using resting state (RS) functional magnetic resonance imaging and independent component analysis, the integrity of brain networks. related to cognition and behavior was investigated in 20 nondemented patients with amyotrophic lateral sclerosis (ALS). The association. between RS functional connectivity and executive functions was assessed in 16 patients with neuropsychological assessment. ALS patients. compared with control subjects showed a decreased connectivity of the right orbitofrontal cortex, and an enhanced connectivity of the left. precuneus in the default mode network; a decreased connectivity of the left inferior frontal cortex, and an increased connectivity of the right. angular gyrus in the right frontoparietal network; and an increased connectivity of the parietal cortex in the left frontoparietal network. The. enhanced parietal connectivity was associated with the clinical and cognitive deficits of the patients. In ALS, an alteration of large-scale. functional brain networks associated with cognition does occur, even in the absence of overt dementia. The increased parietal connectivity. may have a role in an attempt to maintain cognitive efficiency in the presence of structural frontotemporal injury."
- Published
- 2013