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Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys
- Source :
- Neurobiology of Aging. 33:670-680
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Higher serum homocysteine (Hcy) levels in humans are associated with vascular pathology and greater risk for dementia, as well as lower global and regional volumes in frontal lobe and hippocampus. Calorie restriction (CR) in rhesus monkeys (Macaca mulatta) may confer neural protection against age- or Hcy-related vascular pathology. Hcy was collected proximal to a magnetic resonance imaging (MRI) acquisition in aged rhesus monkeys and regressed against volumetric and diffusion tensor imaging indexes using voxel-wise analyses. Higher Hcy was associated with lower white matter volume in pons and corpus callosum. Hcy was correlated with lower gray matter volume and density in prefrontal cortices and striatum. CR did not influence Hcy levels. However, control monkeys exhibited a strong negative correlation between Hcy and global gray matter, whereas no relationship was evident for the CR monkeys. Similar group differences were also seen across modalities in the splenium of the corpus callosum, prefrontal cortices, hippocampus, and somatosensory areas. The data suggest that CR may ameliorate the influence of Hcy on several important age-related parameters of parenchymal health.
- Subjects :
- Male
Aging
medicine.medical_specialty
Hippocampus
Splenium
Corpus callosum
Article
White matter
Atrophy
Internal medicine
biology.animal
Image Processing, Computer-Assisted
medicine
Animals
Primate
Homocysteine
Caloric Restriction
Analysis of Variance
Brain Mapping
biology
General Neuroscience
Age Factors
Brain
Anatomy
Voxel-based morphometry
medicine.disease
Macaca mulatta
Magnetic Resonance Imaging
Diffusion Tensor Imaging
medicine.anatomical_structure
Endocrinology
Frontal lobe
Female
Neurology (clinical)
Geriatrics and Gerontology
Psychology
Developmental Biology
Subjects
Details
- ISSN :
- 01974580
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Neurobiology of Aging
- Accession number :
- edsair.doi.dedup.....0c545a8e30c2e691e722ceeb492f577e