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Your search keyword '"Cathelijne Frielink"' showing total 3 results
Start Over Author "Cathelijne Frielink" Journal nederlands tijdschrift voor diabetologie
3 results on '"Cathelijne Frielink"'

1. PS2 - 8. Correlation of beta cell volume and SPECT signal in transplanted islets, using In-111 labeled exendin-3

Author

Inge van der Kroon, Cathelijne Frielink, Maarten Brom, Martin Gotthardt, Lieke Joosten, and Desiree Bos

Subjects
medicine.medical_specialty, geography, geography.geographical_feature_category, business.industry, Urology, medicine.disease, Islet, Transplantation, Endocrinology, Diabetes mellitus, Internal medicine, medicine, Pancreatic islet transplantation, Linear correlation, Beta cell, Diabetic patient, business, Histological examination
Abstract

Pancreatic islet transplantation is a promising experimental treatment for type I diabetic patients. A non-invasive method to accurately determine beta cell volume in the transplant could give insight in the faith of the islets after transplantation. Such a method will also provide the possibility to monitor the effects of therapeutic interventions on beta cell volume, which could improve the treatment of diabetic patients.

Published
2013
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2. PL - 92. Non-invasive determination of the beta cell mass in rats by SPECT with In-111-DTPA-Exendin-3

Author

Martin Gotthardt, Cathelijne Frielink, Lieke Joosten, Marion de Jong, Wim J.G. Oyen, Maarten Brom, Otto C. Boerman, and Martin Béhé

Subjects
chemistry.chemical_classification, medicine.medical_specialty, Non invasive, Peptide, Biology, medicine.disease, Pathophysiology, Endocrinology, chemistry, In vivo, Diabetes mellitus, Internal medicine, medicine, Beta cell, Receptor, Beta (finance)
Abstract

The beta cell mass (BCM) plays a key role in the development and progression of diabetes mellitus. A reliable, non-invasive method for quantification of the pancreatic (BCM) in vivo would give further insight in the pathophysiology of type 1 and 2 diabetes. The glucagonlike peptide 1 receptor (GLP-1R) is specifically expressed on beta cells.

Published
2011
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3. PS2 - 6. Proof of Principle Study: IBZM based imaging of transplanted islets of Langerhans

Author

Inge van der Kroon, Stefanie M. A. Willekens, Cathelijne Frielink, Lieke Joosten, Maarten Brom, and Martin Gotthardt

Subjects
endocrine system, medicine.medical_specialty, geography, Pathology, geography.geographical_feature_category, endocrine system diseases, business.industry, Islet, medicine.disease, Single photon emission, Transplantation, surgical procedures, operative, Endocrinology, Photon emission, Diabetes mellitus, Internal medicine, medicine, Beta cell, business
Abstract

Currently, transplantation of islets of Langerhans is a promising experimental treatment for diabetes type 1 patients. Despite the ability of the transplanted islets to normalize blood glucose, the rate of insulin-independency drops to less than 15% after 5 years. The visualization of transplanted islets could gain important insights in the processes underlying islet transplantation and might improve the outcome of islet transplantation.

Published
2013
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