51. Current trends in safety testing and toxicological research
- Author
-
G. Zbinden
- Subjects
High probability ,Clinical Trials as Topic ,Experimental model ,business.industry ,Drug Evaluation, Preclinical ,General Medicine ,Toxicology ,United States ,Risk analysis (engineering) ,Animals ,Drug Evaluation ,Humans ,Medicine ,Safety ,Current (fluid) ,Adverse effect ,business ,Safety testing ,Ecology, Evolution, Behavior and Systematics - Abstract
The paper reviews current concepts of toxicological evaluation of new drugs and other chemicals. Instead of completing a predetermined check-list toxicologists now consider the potential adverse effects of the substances under actual conditions of use. They then design experimental models which have a high probability to predict the toxic effects. Moreover, the enhanced susceptibilities of special risk populations is more and more taken into consideration.
- Published
- 1982