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Start Over Author "Pille Harrison" Journal nature genetics
3 results on '"Pille Harrison"'

1. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Author

Eleftheria Zeggini, Michael Weedon, Karl Gaffney, Anne Hinks, Wendy Thomson, Patricia Munroe, Stephen Eyre, Andrew Hattersley, Steven Young-Min, Elizabeth Hensor, Nadira Yusupovna Yuldasheva, Simon Potter, Philip Conaghan, Gerome Breen, Hana Lango Allen, Jane Worthington, Ann Morgan, Professor David Dunger, Pille Harrison, Iain McInnes, Charlie Lees, Anne Barton, Jon Packham, Lynne J Hocking, Kimme Hyrich, John Bowes, Miles Parkes, Anna Dominiczak, and Cecilia Lindgren

Subjects
030203 arthritis & rheumatology, Genetics, 0303 health sciences, Case-control study, Chromosome, Arthritis, Genome-wide association study, Locus (genetics), Single-nucleotide polymorphism, Biology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Genetic linkage, Rheumatoid arthritis, Immunology, medicine, 030304 developmental biology
Abstract

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

Published
2008
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2. Rheumatoid arthritis association at 6q23

Author

Mark Caulfield, Eleftheria Zeggini, Michael Weedon, Anne Hinks, Wendy Thomson, Patricia Munroe, Detelina Grozeva, Stephen Eyre, Andrew Hattersley, David Evans, Neil Walker, Melanie Newport, Deborah Symmons, Lisa Jones, Michael O'Donovan, Elizabeth Hensor, Nadira Yusupovna Yuldasheva, Philip Conaghan, Hana Lango Allen, Jane Worthington, Ann Morgan, Professor David Dunger, Pille Harrison, Rachelle Donn, Charlie Lees, Anne Barton, Martin Tobin, Natalie Prescott, Lynne J Hocking, John Bowes, Ian Bruce, Miles Parkes, James Robinson, Tim Bishop, Richard Dobson, Anna Dominiczak, Mark McCarthy, Cecilia Lindgren, and Alistair Hall

Subjects
Male, Linkage disequilibrium, Population, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, TNFAIP3, Article, Linkage Disequilibrium, Arthritis, Rheumatoid, PTPN22, Gene mapping, Genetics, medicine, Humans, SNP, Genetic Predisposition to Disease, education, education.field_of_study, Genome, Human, Protein Tyrosine Phosphatase, Non-Receptor Type 22, medicine.disease, Rheumatoid arthritis, Immunology, Chromosomes, Human, Pair 6, Female
Abstract

The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3).

Published
2007
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3. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

Author

Robert M. Plenge, Elisabeth Brouwer, Cisca Wijmenga, Christopher I. Amos, Anthony G. Wilson, Noël P. Burtt, Stephen Eyre, Paul P. Tak, Pille Harrison, Daniel L. Kastner, Robert Chen, Gang Xie, Gertjan Wolbink, Bo Ding, Niek de Vries, B. Paul Wordsworth, Paul I.W. de Bakker, David M. Reid, Xiangdong Liu, Mark Seielstad, Tom W J Huizinga, Lynne J. Hocking, Peter K. Gregersen, Leonid Padyukov, Jing Cui, Annette Lee, Sophia Steer, J. Bart A. Crusius, C. Ellen van der Schoot, Yonghong Li, Philip L. De Jager, Michael F. Seldin, Kristin G. Ardlie, Anne Barton, Marieke J H Coenen, Annette H M van der Helm-van Mil, Nancy A. Shadick, Ann W. Morgan, Fina A S Kurreeman, Katherine A. Siminovitch, Elaine F. Remmers, Timothy R D J Radstake, René E. M. Toes, Anne Hinks, Jane Worthington, Karen H. Costenbader, Joseph J. Catanese, Elizabeth W. Karlson, Alexandra Zhernakova, Edward Flynn, Xiayi Ke, Brian Thomson, Soumya Raychaudhuri, Jonathan S. Coblyn, Lars Alfredsson, Marcel D. Posthumus, John Bowes, Irene E. van der Horst-Bruinsma, Ann B. Begovich, Wendy Thomson, Paul Martin, Candace Guiducci, Piet L. C. M. van Riel, Paul Emery, Michael E. Weinblatt, Lars Klareskog, Lindsey A. Criswell, Eli A. Stahl, Rheumatology, CCA - Disease profiling, Pathology, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), AII - Amsterdam institute for Infection and Immunity, Clinical Immunology and Rheumatology, Landsteiner Laboratory, and Clinical Haematology

Subjects
SUSCEPTIBILITY LOCI, Arthritis, Genome-wide association study, Single-nucleotide polymorphism, Biology, VARIANTS, Polymorphism, Single Nucleotide, Auto-immunity, transplantation and immunotherapy [N4i 4], Article, REGION, Arthritis, Rheumatoid, Genomic disorders and inherited multi-system disorders [IGMD 3], Molecular epidemiology [NCEBP 1], systemic-lupus-erythematosus susceptibility loci celiac-disease variants gene common region polymorphisms confirmation replication, Risk Factors, Genetics, medicine, Humans, Genetic Predisposition to Disease, Allele, SYSTEMIC-LUPUS-ERYTHEMATOSUS, Health care ethics [NCEBP 5], COMMON, POLYMORPHISMS, Autoantibodies, Autoantibody, CELIAC-DISEASE, medicine.disease, GENE, CONFIRMATION, Genetic Loci, Evaluation of complex medical interventions [NCEBP 2], Rheumatoid arthritis, PADI4, Immunology, REPLICATION, IRF5, Genome-Wide Association Study
Abstract

Contains fulltext : 88498.pdf (Publisher’s version ) (Closed access) To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid arthritis (cases) and 20,169 controls of European descent, followed by replication in an independent set of 6,768 rheumatoid arthritis cases and 8,806 controls. Of 34 SNPs selected for replication, 7 new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 x 10(-8)) in an analysis of all 41,282 samples. The associated SNPs are near genes of known immune function, including IL6ST, SPRED2, RBPJ, CCR6, IRF5 and PXK. We also refined associations at two established rheumatoid arthritis risk loci (IL2RA and CCL21) and confirmed the association at AFF3. These new associations bring the total number of confirmed rheumatoid arthritis risk loci to 31 among individuals of European ancestry. An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles. 01 juni 2010

Published
2010
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