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Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
- Source :
- Stahl, E A, Raychaudhuri, S, Remmers, E F, Xie, G, Eyre, S, Thomson, B P, Li, Y H, Kurreeman, F A S, Zhernakova, A, Hinks, A, Guiducci, C, Chen, R, Alfredsson, L, Amos, C I, Ardlie, K G, Barton, A, Bowes, J, Brouwer, E, Burtt, N P, Catanese, J J, Coblyn, J, Coenen, M J H, Costenbader, K H, Criswell, L A, Crusius, J B A, Cui, J, Bakker, P I W, de Jager, P L, Ding, B, Emery, P, Flynn, E, Harrison, P, Hocking, L J, Huizinga, T W J, Kastner, D L, Ke, X Y, Lee, A T, Liu, X D, Martin, P, Morgan, A W, Padyukov, L, Posthumus, M D, Radstake, T R D J, Reid, D M, Seielstad, M, Seldin, M F, Shadick, N A, Steer, S, Tak, P P, Thomson, W, van der Helm-va Mil, A, van der Horst-Bruinsma, I E, van der Schoot, C E, van Riel, P L C M, Weinblatt, M E, Wilson, A G, Wolbink, G J J, Wordsworth, B P, Wijmenga, C, Karlson, E W, Toes, R E M, de Vries, N, Begovich, A B, Worthington, J, Siminovitch, K A, Gregersen, P K, Klareskog, L & Plenge, R M 2010, ' Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci ', Nature Genetics, vol. 42, no. 6, pp. 508-514 . https://doi.org/10.1038/ng.582, Nature Genetics, 42, 508-14, Nature Genetics, 42(6), 508-514. Nature Publishing Group, Nature Genetics, 42(6), 508-U56. Nature Publishing Group, Nature Genetics, 42, 6, pp. 508-14, Nature genetics, 42(6), 508-U56. Nature Publishing Group, Nature Genetics, 42(6), 508
- Publication Year :
- 2010
-
Abstract
- Contains fulltext : 88498.pdf (Publisher’s version ) (Closed access) To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid arthritis (cases) and 20,169 controls of European descent, followed by replication in an independent set of 6,768 rheumatoid arthritis cases and 8,806 controls. Of 34 SNPs selected for replication, 7 new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 x 10(-8)) in an analysis of all 41,282 samples. The associated SNPs are near genes of known immune function, including IL6ST, SPRED2, RBPJ, CCR6, IRF5 and PXK. We also refined associations at two established rheumatoid arthritis risk loci (IL2RA and CCL21) and confirmed the association at AFF3. These new associations bring the total number of confirmed rheumatoid arthritis risk loci to 31 among individuals of European ancestry. An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles. 01 juni 2010
- Subjects :
- SUSCEPTIBILITY LOCI
Arthritis
Genome-wide association study
Single-nucleotide polymorphism
Biology
VARIANTS
Polymorphism, Single Nucleotide
Auto-immunity, transplantation and immunotherapy [N4i 4]
Article
REGION
Arthritis, Rheumatoid
Genomic disorders and inherited multi-system disorders [IGMD 3]
Molecular epidemiology [NCEBP 1]
systemic-lupus-erythematosus susceptibility loci celiac-disease variants gene common region polymorphisms confirmation replication
Risk Factors
Genetics
medicine
Humans
Genetic Predisposition to Disease
Allele
SYSTEMIC-LUPUS-ERYTHEMATOSUS
Health care ethics [NCEBP 5]
COMMON
POLYMORPHISMS
Autoantibodies
Autoantibody
CELIAC-DISEASE
medicine.disease
GENE
CONFIRMATION
Genetic Loci
Evaluation of complex medical interventions [NCEBP 2]
Rheumatoid arthritis
PADI4
Immunology
REPLICATION
IRF5
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 15461718 and 10614036
- Volume :
- 42
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Nature genetics
- Accession number :
- edsair.doi.dedup.....b61dda1ae57d1d63bce515394af10052