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18 results on '"Keppler, P"'

2. Methane formation driven by light and heat prior to the origin of life and beyond

Author

Leonard Ernst, Uladzimir Barayeu, Jonas Hädeler, Tobias P. Dick, Judith M. Klatt, Frank Keppler, and Johannes G. Rebelein

Subjects
Science
Abstract

Abstract Methane is a potent greenhouse gas, which likely enabled the evolution of life by keeping the early Earth warm. Here, we demonstrate routes towards abiotic methane and ethane formation under early-earth conditions from methylated sulfur and nitrogen compounds with prebiotic origin. These compounds are demethylated in Fenton reactions governed by ferrous iron and reactive oxygen species (ROS) produced by light and heat in aqueous environments. After the emergence of life, this phenomenon would have greatly intensified in the anoxic Archean by providing methylated sulfur and nitrogen substrates. This ROS-driven Fenton chemistry can occur delocalized from serpentinization across Earth’s humid realm and thereby substantially differs from previously suggested methane formation routes that are spatially restricted. Here, we report that Fenton reactions driven by light and heat release methane and ethane and might have shaped the chemical evolution of the atmosphere prior to the origin of life and beyond.

Published
2023
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3. Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection

Author

Elham Khatamzas, Markus H. Antwerpen, Alexandra Rehn, Alexander Graf, Johannes Christian Hellmuth, Alexandra Hollaus, Anne-Wiebe Mohr, Erik Gaitzsch, Tobias Weiglein, Enrico Georgi, Clemens Scherer, Stephanie-Susanne Stecher, Stefanie Gruetzner, Helmut Blum, Stefan Krebs, Anna Reischer, Alexandra Leutbecher, Marion Subklewe, Andrea Dick, Sabine Zange, Philipp Girl, Katharina Müller, Oliver Weigert, Karl-Peter Hopfner, Hans-Joachim Stemmler, Michael von Bergwelt-Baildon, Oliver T. Keppler, Roman Wölfel, Maximilian Muenchhoff, and Andreas Moosmann

Subjects
Science
Abstract

SARS-CoV-2 mutations associated with the escape from antibody-mediated neutralization have been widely reported. Here, in a patient with defective antibody responses, the authors find a potential association between SARS-CoV-2 mutations and CD8 T alterations to implicate possible contributions of CD8 T cells in evasion of SARS-CoV-2 from host immunity.

Published
2022
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4. Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection

Author

Khatamzas, Elham, Antwerpen, Markus H., Rehn, Alexandra, Graf, Alexander, Hellmuth, Johannes Christian, Hollaus, Alexandra, Mohr, Anne-Wiebe, Gaitzsch, Erik, Weiglein, Tobias, Georgi, Enrico, Scherer, Clemens, Stecher, Stephanie-Susanne, Gruetzner, Stefanie, Blum, Helmut, Krebs, Stefan, Reischer, Anna, Leutbecher, Alexandra, Subklewe, Marion, Dick, Andrea, Zange, Sabine, Girl, Philipp, Müller, Katharina, Weigert, Oliver, Hopfner, Karl-Peter, Stemmler, Hans-Joachim, von Bergwelt-Baildon, Michael, Keppler, Oliver T., Wölfel, Roman, Muenchhoff, Maximilian, and Moosmann, Andreas

Published
2022
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5. Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19

Author

Paul, Tanja, Ledderose, Stephan, Bartsch, Harald, Sun, Na, Soliman, Sarah, Märkl, Bruno, Ruf, Viktoria, Herms, Jochen, Stern, Marcel, Keppler, Oliver T., Delbridge, Claire, Müller, Susanna, Piontek, Guido, Kimoto, Yuki Schneider, Schreiber, Franziska, Williams, Tracy Ann, Neumann, Jens, Knösel, Thomas, Schulz, Heiko, Spallek, Ria, Graw, Matthias, Kirchner, Thomas, Walch, Axel, and Rudelius, Martina

Published
2022
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6. Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

Author

Pekayvaz, Kami, Leunig, Alexander, Kaiser, Rainer, Joppich, Markus, Brambs, Sophia, Janjic, Aleksandar, Popp, Oliver, Nixdorf, Daniel, Fumagalli, Valeria, Schmidt, Nora, Polewka, Vivien, Anjum, Afra, Knottenberg, Viktoria, Eivers, Luke, Wange, Lucas E., Gold, Christoph, Kirchner, Marieluise, Muenchhoff, Maximilian, Hellmuth, Johannes C., Scherer, Clemens, Rubio-Acero, Raquel, Eser, Tabea, Deák, Flora, Puchinger, Kerstin, Kuhl, Niklas, Linder, Andreas, Saar, Kathrin, Tomas, Lukas, Schulz, Christian, Wieser, Andreas, Enard, Wolfgang, Kroidl, Inge, Geldmacher, Christof, von Bergwelt-Baildon, Michael, Keppler, Oliver T., Munschauer, Mathias, Iannacone, Matteo, Zimmer, Ralf, Mertins, Philipp, Hubner, Norbert, Hoelscher, Michael, Massberg, Steffen, Stark, Konstantin, and Nicolai, Leo

Published
2022
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7. Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents

Author

Koerber, Nina, Priller, Alina, Yazici, Sarah, Bauer, Tanja, Cheng, Cho-Chin, Mijočević, Hrvoje, Wintersteller, Hannah, Jeske, Samuel, Vogel, Emanuel, Feuerherd, Martin, Tinnefeld, Kathrin, Winter, Christof, Ruland, Jürgen, Gerhard, Markus, Haller, Bernhard, Christa, Catharina, Zelger, Otto, Roggendorf, Hedwig, Halle, Martin, Erber, Johanna, Lingor, Paul, Keppler, Oliver, Zehn, Dietmar, Protzer, Ulrike, and Knolle, Percy A.

Published
2022
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8. Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19

Author

Tanja Paul, Stephan Ledderose, Harald Bartsch, Na Sun, Sarah Soliman, Bruno Märkl, Viktoria Ruf, Jochen Herms, Marcel Stern, Oliver T. Keppler, Claire Delbridge, Susanna Müller, Guido Piontek, Yuki Schneider Kimoto, Franziska Schreiber, Tracy Ann Williams, Jens Neumann, Thomas Knösel, Heiko Schulz, Ria Spallek, Matthias Graw, Thomas Kirchner, Axel Walch, and Martina Rudelius

Subjects
Science
Abstract

Progressive respiratory failure is the primary cause of death in patients with COVID-19, but pathologies in other tissues may also occur. Here the authors report that adrenal tropism of SARS-CoV-2 is associated with adrenalitis, reduced adrenal cortisol levels and severe adrenal damage in a post-mortem case series of patients with severe fatal COVID-19.

Published
2022
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9. Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

Author

Kami Pekayvaz, Alexander Leunig, Rainer Kaiser, Markus Joppich, Sophia Brambs, Aleksandar Janjic, Oliver Popp, Daniel Nixdorf, Valeria Fumagalli, Nora Schmidt, Vivien Polewka, Afra Anjum, Viktoria Knottenberg, Luke Eivers, Lucas E. Wange, Christoph Gold, Marieluise Kirchner, Maximilian Muenchhoff, Johannes C. Hellmuth, Clemens Scherer, Raquel Rubio-Acero, Tabea Eser, Flora Deák, Kerstin Puchinger, Niklas Kuhl, Andreas Linder, Kathrin Saar, Lukas Tomas, Christian Schulz, Andreas Wieser, Wolfgang Enard, Inge Kroidl, Christof Geldmacher, Michael von Bergwelt-Baildon, Oliver T. Keppler, Mathias Munschauer, Matteo Iannacone, Ralf Zimmer, Philipp Mertins, Norbert Hubner, Michael Hoelscher, Steffen Massberg, Konstantin Stark, and Leo Nicolai

Subjects
Science
Abstract

Infection with SARS-COV-2 can result in self-limited upper airway infection or progress to a more systemic inflammatory condition including pneumonic COVID-19. Here the authors utilise a multi-omics approach to interrogate the immune response of patients with self-limiting upper respiratory SARS-CoV-2 infection and reveal a temporal immune trajectory they associate with viral containment and restriction from pneumonic progressive disease.

Published
2022
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10. Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents

Author

Nina Koerber, Alina Priller, Sarah Yazici, Tanja Bauer, Cho-Chin Cheng, Hrvoje Mijočević, Hannah Wintersteller, Samuel Jeske, Emanuel Vogel, Martin Feuerherd, Kathrin Tinnefeld, Christof Winter, Jürgen Ruland, Markus Gerhard, Bernhard Haller, Catharina Christa, Otto Zelger, Hedwig Roggendorf, Martin Halle, Johanna Erber, Paul Lingor, Oliver Keppler, Dietmar Zehn, Ulrike Protzer, and Percy A. Knolle

Subjects
Science
Abstract

Waning immunity to SARS-CoV-2 is of concern. Here the authors follow spike- and nucleocapsid specific immunity in convalescent individuals for 9 months observing a decline in antibody levels but persisting T cell response. Vaccination approximately 11 months after infection boosts antibody and T cell immunity.

Published
2022
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11. Human FCHO1 deficiency reveals role for clathrin-mediated endocytosis in development and function of T cells

Author

Marcin Łyszkiewicz, Natalia Ziętara, Laura Frey, Ulrich Pannicke, Marcel Stern, Yanshan Liu, Yanxin Fan, Jacek Puchałka, Sebastian Hollizeck, Ido Somekh, Meino Rohlfs, Tuğba Yilmaz, Ekrem Ünal, Musa Karakukcu, Türkan Patiroğlu, Christina Kellerer, Ebru Karasu, Karl-Walter Sykora, Atar Lev, Amos Simon, Raz Somech, Joachim Roesler, Manfred Hoenig, Oliver T. Keppler, Klaus Schwarz, and Christoph Klein

Subjects
Science
Abstract

FCH domain only 1 (FCHO1) is a key molecule involved in clathrin-mediated endocytosis (CME). Here, the authors report homozygous FCHO1 mutations in individuals with variable T and B cell lymphopenia, which are associated with loss-of-function of FCHO1 and impaired formation of clathrin-coated pits in T cells.

Published
2020
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12. Carbon-nanotube reinforcement of DNA-silica nanocomposites yields programmable and cell-instructive biocoatings

Author

Yong Hu, Carmen M. Domínguez, Jens Bauer, Simone Weigel, Alessa Schipperges, Claude Oelschlaeger, Norbert Willenbacher, Stephan Keppler, Martin Bastmeyer, Stefan Heißler, Christof Wöll, Tim Scharnweber, Kersten S. Rabe, and Christof M. Niemeyer

Subjects
Science
Abstract

DNA composite materials have potential for biomedical sciences; however, control over the materials can be an issue. Here, the authors report on a carbon-nanotube reinforced DNA-silica gel with controllable mechanical properties to steer the attachment, proliferation, migration and release of cells.

Published
2019
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13. Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML

Author

Thomas Oellerich, Constanze Schneider, Dominique Thomas, Kirsten M. Knecht, Olga Buzovetsky, Lars Kaderali, Christoph Schliemann, Hanibal Bohnenberger, Linus Angenendt, Wolfgang Hartmann, Eva Wardelmann, Tamara Rothenburger, Sebastian Mohr, Sebastian Scheich, Federico Comoglio, Anne Wilke, Philipp Ströbel, Hubert Serve, Martin Michaelis, Nerea Ferreirós, Gerd Geisslinger, Yong Xiong, Oliver T. Keppler, and Jindrich Cinatl

Subjects
Science
Abstract

In acute myeloid leukemia, hypomethylating agents decitabine and azacytidine are used interchangeably. Here, the authors show that the major metabolite of decitabine, but not azacytidine, is subject to SAMHD1 inactivation, highlighting SAMHD1 as a potential biomarker and therapeutic target

Published
2019
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14. Human FCHO1 deficiency reveals role for clathrin-mediated endocytosis in development and function of T cells

Author

Łyszkiewicz, Marcin, Ziętara, Natalia, Frey, Laura, Pannicke, Ulrich, Stern, Marcel, Liu, Yanshan, Fan, Yanxin, Puchałka, Jacek, Hollizeck, Sebastian, Somekh, Ido, Rohlfs, Meino, Yilmaz, Tuğba, Ünal, Ekrem, Karakukcu, Musa, Patiroğlu, Türkan, Kellerer, Christina, Karasu, Ebru, Sykora, Karl-Walter, Lev, Atar, Simon, Amos, Somech, Raz, Roesler, Joachim, Hoenig, Manfred, Keppler, Oliver T., Schwarz, Klaus, and Klein, Christoph

Published
2020
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15. Author Correction: Human FCHO1 deficiency reveals role for clathrin-mediated endocytosis in development and function of T cells

Author

Łyszkiewicz, Marcin, Ziętara, Natalia, Frey, Laura, Pannicke, Ulrich, Stern, Marcel, Liu, Yanshan, Fan, Yanxin, Puchałka, Jacek, Hollizeck, Sebastian, Somekh, Ido, Rohlfs, Meino, Yilmaz, Tuğba, Ünal, Ekrem, Karakukcu, Musa, Patiroğlu, Türkan, Kellerer, Christina, Karasu, Ebru, Sykora, Karl-Walter, Lev, Atar, Simon, Amos, Somech, Raz, Roesler, Joachim, Hoenig, Manfred, Keppler, Oliver T., Schwarz, Klaus, and Klein, Christoph

Published
2020
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17. Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML

Author

Oellerich, Thomas, Schneider, Constanze, Thomas, Dominique, Knecht, Kirsten M., Buzovetsky, Olga, Kaderali, Lars, Schliemann, Christoph, Bohnenberger, Hanibal, Angenendt, Linus, Hartmann, Wolfgang, Wardelmann, Eva, Rothenburger, Tamara, Mohr, Sebastian, Scheich, Sebastian, Comoglio, Federico, Wilke, Anne, Ströbel, Philipp, Serve, Hubert, Michaelis, Martin, Ferreirós, Nerea, Geisslinger, Gerd, Xiong, Yong, Keppler, Oliver T., and Cinatl, Jr., Jindrich

Published
2019
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18. Author Correction: Human FCHO1 deficiency reveals role for clathrin-mediated endocytosis in development and function of T cells

Author

Marcin Łyszkiewicz, Natalia Ziętara, Laura Frey, Ulrich Pannicke, Marcel Stern, Yanshan Liu, Yanxin Fan, Jacek Puchałka, Sebastian Hollizeck, Ido Somekh, Meino Rohlfs, Tuğba Yilmaz, Ekrem Ünal, Musa Karakukcu, Türkan Patiroğlu, Christina Kellerer, Ebru Karasu, Karl-Walter Sykora, Atar Lev, Amos Simon, Raz Somech, Joachim Roesler, Manfred Hoenig, Oliver T. Keppler, Klaus Schwarz, and Christoph Klein

Subjects
Science
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020
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