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19 results on '"Eggert P"'

1. Author Correction: Environmental, economic, and social sustainability in aquaculture: the aquaculture performance indicators

Author

Garlock, Taryn M., Asche, Frank, Anderson, James L., Eggert, Håkan, Anderson, Thomas M., Che, Bin, Chávez, Carlos A., Chu, Jingjie, Chukwuone, Nnaemeka, Dey, Madan M., Fitzsimmons, Kevin, Flores, Jimely, Guillen, Jordi, Kumar, Ganesh, Liu, Lijun, Llorente, Ignacio, Nguyen, Ly, Nielsen, Rasmus, Pincinato, Ruth B. M., Sudhakaran, Pratheesh O., Tibesigwa, Byela, and Tveteras, Ragnar

Published
2024
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2. Environmental, economic, and social sustainability in aquaculture: the aquaculture performance indicators

Author

Garlock, Taryn M., Asche, Frank, Anderson, James L., Eggert, Håkan, Anderson, Thomas M., Che, Bin, Chávez, Carlos A., Chu, Jingjie, Chukwuone, Nnaemeka, Dey, Madan M., Fitzsimmons, Kevin, Flores, Jimely, Guillen, Jordi, Kumar, Ganesh, Liu, Lijun, Llorente, Ignacio, Nguyen, Ly, Nielsen, Rasmus, Pincinato, Ruth B. M., Sudhakaran, Pratheesh O., Tibesigwa, Byela, and Tveteras, Ragnar

Published
2024
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3. Environmental, economic, and social sustainability in aquaculture: the aquaculture performance indicators

Author

Taryn M. Garlock, Frank Asche, James L. Anderson, Håkan Eggert, Thomas M. Anderson, Bin Che, Carlos A. Chávez, Jingjie Chu, Nnaemeka Chukwuone, Madan M. Dey, Kevin Fitzsimmons, Jimely Flores, Jordi Guillen, Ganesh Kumar, Lijun Liu, Ignacio Llorente, Ly Nguyen, Rasmus Nielsen, Ruth B. M. Pincinato, Pratheesh O. Sudhakaran, Byela Tibesigwa, and Ragnar Tveteras

Subjects
Science
Abstract

Abstract Aquaculture is a rapidly growing food production technology, but there are significant concerns related to its environmental impact and adverse social effects. We examine aquaculture outcomes in a three pillars of sustainability framework by analyzing data collected using the Aquaculture Performance Indicators. Using this approach, comparable data has been collected for 57 aquaculture systems worldwide on 88 metrics that measure social, economic, or environmental outcomes. We first examine the relationships among the three pillars of sustainability and then analyze performance in the three pillars by technology and species. The results show that economic, social, and environmental outcomes are, on average, mutually reinforced in global aquaculture systems. However, the analysis also shows significant variation in the degree of sustainability in different aquaculture systems, and weak performance of some production systems in some dimensions provides opportunity for innovative policy measures and investment to further align sustainability objectives.

Published
2024
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4. Extended X-ray absorption fine structure of dynamically-compressed copper up to 1 terapascal

Author

H. Sio, A. Krygier, D. G. Braun, R. E. Rudd, S. A. Bonev, F. Coppari, M. Millot, D. E. Fratanduono, N. Bhandarkar, M. Bitter, D. K. Bradley, P. C. Efthimion, J. H. Eggert, L. Gao, K. W. Hill, R. Hood, W. Hsing, N. Izumi, G. Kemp, B. Kozioziemski, O. L. Landen, K. Le Galloudec, T. E. Lockard, A. Mackinnon, J. M. McNaney, N. Ose, H.-S. Park, B. A. Remington, M. B. Schneider, S. Stoupin, D. B. Thorn, S. Vonhof, C. J. Wu, and Y. Ping

Subjects
Science
Abstract

Abstract Large laser facilities have recently enabled material characterization at the pressures of Earth and Super-Earth cores. However, the temperature of the compressed materials has been largely unknown, or solely relied on models and simulations, due to lack of diagnostics under these challenging conditions. Here, we report on temperature, density, pressure, and local structure of copper determined from extended x-ray absorption fine structure and velocimetry up to 1 Terapascal. These results nearly double the highest pressure at which extended x-ray absorption fine structure has been reported in any material. In this work, the copper temperature is unexpectedly found to be much higher than predicted when adjacent to diamond layer(s), demonstrating the important influence of the sample environment on the thermal state of materials; this effect may introduce additional temperature uncertainties in some previous experiments using diamond and provides new guidance for future experimental design.

Published
2023
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5. Author Correction: Environmental, economic, and social sustainability in aquaculture: the aquaculture performance indicators

Author

Taryn M. Garlock, Frank Asche, James L. Anderson, Håkan Eggert, Thomas M. Anderson, Bin Che, Carlos A. Chávez, Jingjie Chu, Nnaemeka Chukwuone, Madan M. Dey, Kevin Fitzsimmons, Jimely Flores, Jordi Guillen, Ganesh Kumar, Lijun Liu, Ignacio Llorente, Ly Nguyen, Rasmus Nielsen, Ruth B. M. Pincinato, Pratheesh O. Sudhakaran, Byela Tibesigwa, and Ragnar Tveteras

Subjects
Science
Published
2024
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6. Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

Author

Steffen Fuchs, Clara Danßmann, Filippos Klironomos, Annika Winkler, Jörg Fallmann, Louisa-Marie Kruetzfeldt, Annabell Szymansky, Julian Naderi, Stephan H. Bernhart, Laura Grunewald, Konstantin Helmsauer, Elias Rodriguez-Fos, Marieluise Kirchner, Philipp Mertins, Kathy Astrahantseff, Christin Suenkel, Joern Toedling, Fabienne Meggetto, Marc Remke, Peter F. Stadler, Patrick Hundsdoerfer, Hedwig E. Deubzer, Annette Künkele, Peter Lang, Jörg Fuchs, Anton G. Henssen, Angelika Eggert, Nikolaus Rajewsky, Falk Hertwig, and Johannes H. Schulte

Subjects
Science
Abstract

Abstract Circular RNAs (circRNAs) are a regulatory RNA class. While cancer-driving functions have been identified for single circRNAs, how they modulate gene expression in cancer is not well understood. We investigate circRNA expression in the pediatric malignancy, neuroblastoma, through deep whole-transcriptome sequencing in 104 primary neuroblastomas covering all risk groups. We demonstrate that MYCN amplification, which defines a subset of high-risk cases, causes globally suppressed circRNA biogenesis directly dependent on the DHX9 RNA helicase. We detect similar mechanisms in shaping circRNA expression in the pediatric cancer medulloblastoma implying a general MYCN effect. Comparisons to other cancers identify 25 circRNAs that are specifically upregulated in neuroblastoma, including circARID1A. Transcribed from the ARID1A tumor suppressor gene, circARID1A promotes cell growth and survival, mediated by direct interaction with the KHSRP RNA-binding protein. Our study highlights the importance of MYCN regulating circRNAs in cancer and identifies molecular mechanisms, which explain their contribution to neuroblastoma pathogenesis.

Published
2023
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7. Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases

Author

A. Emilia Arguello, Ang Li, Xuemeng Sun, Tanner W. Eggert, Elisabeth Mairhofer, and Ralph E. Kleiner

Subjects
Science
Abstract

Kleiner and co-workers profile RNA 5-methylcytidine (m5C) dioxygenase enzymes using an activity-based metabolic probing strategy. They reveal ALKBH1 as the major 5-formylcytidine (f5C) writer and characterize modification sites across mRNA and tRNA.

Published
2022
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8. Therapeutic targeting of ATR in alveolar rhabdomyosarcoma

Author

Heathcliff Dorado García, Fabian Pusch, Yi Bei, Jennifer von Stebut, Glorymar Ibáñez, Kristina Guillan, Koshi Imami, Dennis Gürgen, Jana Rolff, Konstantin Helmsauer, Stephanie Meyer-Liesener, Natalie Timme, Victor Bardinet, Rocío Chamorro González, Ian C. MacArthur, Celine Y. Chen, Joachim Schulz, Antje M. Wengner, Christian Furth, Birgit Lala, Angelika Eggert, Georg Seifert, Patrick Hundsoerfer, Marieluise Kirchner, Philipp Mertins, Matthias Selbach, Andrej Lissat, Frank Dubois, David Horst, Johannes H. Schulte, Simone Spuler, Daoqi You, Filemon Dela Cruz, Andrew L. Kung, Kerstin Haase, Michela DiVirgilio, Monika Scheer, Michael V. Ortiz, and Anton G. Henssen

Subjects
Science
Abstract

Alveolar rhabdomyosarcoma is a clinically challenging disease due to the lack of druggable targets. Here the authors show preclinical evidence for ATR inhibitors as a therapeutic option for alveolar rhabdomyosarcoma.

Published
2022
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9. Structure and density of silicon carbide to 1.5 TPa and implications for extrasolar planets

Author

D. Kim, R. F. Smith, I. K. Ocampo, F. Coppari, M. C. Marshall, M. K. Ginnane, J. K. Wicks, S. J. Tracy, M. Millot, A. Lazicki, J. R. Rygg, J. H. Eggert, and T. S. Duffy

Subjects
Science
Abstract

Using ramp compression, silicon carbide was compressed to pressures of 1.5 terapascals, more than seven times higher than previous work. The results show that large carbon-rich exoplanets would be ~10% less dense than corresponding rocky planets.

Published
2022
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11. Therapeutic targeting of ATR in alveolar rhabdomyosarcoma

Author

Dorado García, Heathcliff, Pusch, Fabian, Bei, Yi, von Stebut, Jennifer, Ibáñez, Glorymar, Guillan, Kristina, Imami, Koshi, Gürgen, Dennis, Rolff, Jana, Helmsauer, Konstantin, Meyer-Liesener, Stephanie, Timme, Natalie, Bardinet, Victor, Chamorro González, Rocío, MacArthur, Ian C., Chen, Celine Y., Schulz, Joachim, Wengner, Antje M., Furth, Christian, Lala, Birgit, Eggert, Angelika, Seifert, Georg, Hundsoerfer, Patrick, Kirchner, Marieluise, Mertins, Philipp, Selbach, Matthias, Lissat, Andrej, Dubois, Frank, Horst, David, Schulte, Johannes H., Spuler, Simone, You, Daoqi, Dela Cruz, Filemon, Kung, Andrew L., Haase, Kerstin, DiVirgilio, Michela, Scheer, Monika, Ortiz, Michael V., and Henssen, Anton G.

Published
2022
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14. Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions

Author

Karin Schmelz, Joern Toedling, Matt Huska, Maja C. Cwikla, Louisa-Marie Kruetzfeldt, Jutta Proba, Peter F. Ambros, Inge M. Ambros, Sengül Boral, Marco Lodrini, Celine Y. Chen, Martin Burkert, Dennis Guergen, Annabell Szymansky, Kathy Astrahantseff, Annette Kuenkele, Kerstin Haase, Matthias Fischer, Hedwig E. Deubzer, Falk Hertwig, Patrick Hundsdoerfer, Anton G. Henssen, Roland F. Schwarz, Johannes H. Schulte, and Angelika Eggert

Subjects
Science
Abstract

Neuroblastoma is a devastating tumour in children. Here, the authors analyse multi-region patient samples using genomics and transcriptomics, revealing temporal and spatial heterogeneity and questioning the reliability of single-biopsy based diagnostics.

Published
2021
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15. Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma

Author

Konstantin Helmsauer, Maria E. Valieva, Salaheddine Ali, Rocío Chamorro González, Robert Schöpflin, Claudia Röefzaad, Yi Bei, Heathcliff Dorado Garcia, Elias Rodriguez-Fos, Montserrat Puiggròs, Katharina Kasack, Kerstin Haase, Csilla Keskeny, Celine Y. Chen, Luis P. Kuschel, Philipp Euskirchen, Verena Heinrich, Michael I. Robson, Carolina Rosswog, Joern Toedling, Annabell Szymansky, Falk Hertwig, Matthias Fischer, David Torrents, Angelika Eggert, Johannes H. Schulte, Stefan Mundlos, Anton G. Henssen, and Richard P. Koche

Subjects
Science
Abstract

MYCN amplification is common in neuroblastomas. Here the authors analyse the MYCN amplicon structure and its epigenetic regulation by integrating short- and longread genomic and epigenomic data and find two classes of MYCN amplicons in neuroblastomas, one driven by local enhancers and the other by hijacking of distal regulatory elements.

Published
2020
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16. Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions

Author

Schmelz, Karin, Toedling, Joern, Huska, Matt, Cwikla, Maja C., Kruetzfeldt, Louisa-Marie, Proba, Jutta, Ambros, Peter F., Ambros, Inge M., Boral, Sengül, Lodrini, Marco, Chen, Celine Y., Burkert, Martin, Guergen, Dennis, Szymansky, Annabell, Astrahantseff, Kathy, Kuenkele, Annette, Haase, Kerstin, Fischer, Matthias, Deubzer, Hedwig E., Hertwig, Falk, Hundsdoerfer, Patrick, Henssen, Anton G., Schwarz, Roland F., Schulte, Johannes H., and Eggert, Angelika

Published
2021
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17. Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma

Author

Helmsauer, Konstantin, Valieva, Maria E., Ali, Salaheddine, Chamorro González, Rocío, Schöpflin, Robert, Röefzaad, Claudia, Bei, Yi, Dorado Garcia, Heathcliff, Rodriguez-Fos, Elias, Puiggròs, Montserrat, Kasack, Katharina, Haase, Kerstin, Keskeny, Csilla, Chen, Celine Y., Kuschel, Luis P., Euskirchen, Philipp, Heinrich, Verena, Robson, Michael I., Rosswog, Carolina, Toedling, Joern, Szymansky, Annabell, Hertwig, Falk, Fischer, Matthias, Torrents, David, Eggert, Angelika, Schulte, Johannes H., Mundlos, Stefan, Henssen, Anton G., and Koche, Richard P.

Published
2020
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19. Structural complexity in ramp-compressed sodium to 480 GPa

Author

Danae N. Polsin, Amy Lazicki, Xuchen Gong, Stephen J. Burns, Federica Coppari, Linda E. Hansen, Brian J. Henderson, Margaret F. Huff, Malcolm I. McMahon, Marius Millot, Reetam Paul, Raymond F. Smith, Jon H. Eggert, Gilbert W. Collins, and J. Ryan Rygg

Subjects
Science
Abstract

The properties of materials can be drastically modified under extreme pressure. Here the authors investigate ramp-compressed sodium to 5 million atmospheres with in situ X-ray diffraction and optical reflectivity, revealing a complex temperature-driven polymorphism and suggesting the formation of a previously predicted electride phase.

Published
2022
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