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Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions

Authors :
Karin Schmelz
Joern Toedling
Matt Huska
Maja C. Cwikla
Louisa-Marie Kruetzfeldt
Jutta Proba
Peter F. Ambros
Inge M. Ambros
Sengül Boral
Marco Lodrini
Celine Y. Chen
Martin Burkert
Dennis Guergen
Annabell Szymansky
Kathy Astrahantseff
Annette Kuenkele
Kerstin Haase
Matthias Fischer
Hedwig E. Deubzer
Falk Hertwig
Patrick Hundsdoerfer
Anton G. Henssen
Roland F. Schwarz
Johannes H. Schulte
Angelika Eggert
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Neuroblastoma is a devastating tumour in children. Here, the authors analyse multi-region patient samples using genomics and transcriptomics, revealing temporal and spatial heterogeneity and questioning the reliability of single-biopsy based diagnostics.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.2390ab09b04a41c28245bac3ed08f2c9
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-26870-z