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Start Over Author "Disanza A" Journal nature communications
13 results on '"Disanza A"'

1. TDP-43 proteinopathy in ALS is triggered by loss of ASRGL1 and associated with HML-2 expression

Author

Garcia-Montojo, Marta, Fathi, Saeed, Rastegar, Cyrus, Simula, Elena Rita, Doucet-O’Hare, Tara, Cheng, Y. H. Hank, Abrams, Rachel P. M., Pasternack, Nicholas, Malik, Nasir, Bachani, Muzna, Disanza, Brianna, Maric, Dragan, Lee, Myoung-Hwa, Wang, Herui, Santamaria, Ulisses, Li, Wenxue, Sampson, Kevon, Lorenzo, Juan Ramiro, Sanchez, Ignacio E., Mezghrani, Alexandre, Li, Yan, Sechi, Leonardo Antonio, Pineda, Sebastian, Heiman, Myriam, Kellis, Manolis, Steiner, Joseph, and Nath, Avindra

Published
2024
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2. IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules

Author

Sara Bisi, Stefano Marchesi, Abrar Rizvi, Davide Carra, Galina V. Beznoussenko, Ines Ferrara, Gianluca Deflorian, Alexander Mironov, Giovanni Bertalot, Federica Pisati, Amanda Oldani, Angela Cattaneo, Ghazaleh Saberamoli, Salvatore Pece, Giuseppe Viale, Angela Bachi, Claudio Tripodo, Giorgio Scita, and Andrea Disanza

Subjects
Science
Abstract

The I-BAR protein IRSp53 senses membrane curvature but its physiological role is unclear. Here, the authors show that during early lumen morphogenesis, IRSp53 controls the shape of the apical plasma membrane and polarized trafficking and ensures the correct epithelial tubular architecture and if deleted, affects renal tubules morphogenesis in various organisms.

Published
2020
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3. A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior

Author

Irene Schiano Lomoriello, Giovanni Giangreco, Claudia Iavarone, Chiara Tordonato, Giusi Caldieri, Gaetana Serio, Stefano Confalonieri, Stefano Freddi, Fabrizio Bianchi, Stefania Pirroni, Giovanni Bertalot, Giuseppe Viale, Davide Disalvatore, Daniela Tosoni, Maria Grazia Malabarba, Andrea Disanza, Giorgio Scita, Salvatore Pece, Brian K. Pilcher, Manuela Vecchi, Sara Sigismund, and Pier Paolo Di Fiore

Subjects
Science
Abstract

It is unclear if genetic alterations in endocytic proteins play a causal role in high incidence human cancers. Here, the authors report the oncogenic role of Epsin3 (EPN3) in breast cancer, and show EPN3 to drive tumorigenesis through induction of a partial epithelial mesenchymal transition state and a TGFβ-dependent regulatory loop that promotes cellular plasticity and invasive behaviour.

Published
2020
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5. Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis

Author

Mugdha Sathe, Gayatri Muthukrishnan, James Rae, Andrea Disanza, Mukund Thattai, Giorgio Scita, Robert G. Parton, and Satyajit Mayor

Subjects
Science
Abstract

Several endocytic pathways operate simultaneously at the cell surface, including the clathrin and dynamin-independent CLIC/GEEC (CG) pathway. Here the authors show that small GTPases and BAR domain proteins regulate branched actin to make clathrin and dynamin-independent endocytic vesicles.

Published
2018
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6. A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration

Author

Salvatore Corallino, Chiara Malinverno, Beate Neumann, Christian Tischer, Andrea Palamidessi, Emanuela Frittoli, Magdalini Panagiotakopoulou, Andrea Disanza, Gema Malet-Engra, Paulina Nastaly, Camilla Galli, Chiara Luise, Giovanni Bertalot, Salvatore Pece, Pier Paolo Di Fiore, Nils Gauthier, Aldo Ferrari, Paolo Maiuri, and Giorgio Scita

Subjects
Science
Abstract

Circular dorsal ruffles (CDRs) are apical actin enriched structures involved in the interpretation of growth factor gradients during cell migration. Here, the authors find that a RAB35/PI3K axis is necessary and sufficient for the formation and stabilization of polarized CDRs and persistent directional migration.

Published
2018
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7. Author Correction: A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration

Author

Salvatore Corallino, Chiara Malinverno, Beate Neumann, Christian Tischer, Andrea Palamidessi, Emanuela Frittoli, Magdalini Panagiotakopoulou, Andrea Disanza, Gema Malet-Engra, Paulina Nastaly, Camilla Galli, Chiara Luise, Giovanni Bertalot, Salvatore Pece, Pier Paolo Di Fiore, Nils Gauthier, Aldo Ferrari, Paolo Maiuri, and Giorgio Scita

Subjects
Science
Abstract

The originally published version of this Article contained an error in the name of the author Salvatore Corallino, which was incorrectly given as Corallino Salvatore. This has now been corrected in both the PDF and HTML versions of the Article.

Published
2018
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8. IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules

Author

Bisi, Sara, primary, Marchesi, Stefano, additional, Rizvi, Abrar, additional, Carra, Davide, additional, Beznoussenko, Galina V., additional, Ferrara, Ines, additional, Deflorian, Gianluca, additional, Mironov, Alexander, additional, Bertalot, Giovanni, additional, Pisati, Federica, additional, Oldani, Amanda, additional, Cattaneo, Angela, additional, Saberamoli, Ghazaleh, additional, Pece, Salvatore, additional, Viale, Giuseppe, additional, Bachi, Angela, additional, Tripodo, Claudio, additional, Scita, Giorgio, additional, and Disanza, Andrea, additional

Published
2020
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9. A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior

Author

Schiano Lomoriello, Irene, primary, Giangreco, Giovanni, additional, Iavarone, Claudia, additional, Tordonato, Chiara, additional, Caldieri, Giusi, additional, Serio, Gaetana, additional, Confalonieri, Stefano, additional, Freddi, Stefano, additional, Bianchi, Fabrizio, additional, Pirroni, Stefania, additional, Bertalot, Giovanni, additional, Viale, Giuseppe, additional, Disalvatore, Davide, additional, Tosoni, Daniela, additional, Malabarba, Maria Grazia, additional, Disanza, Andrea, additional, Scita, Giorgio, additional, Pece, Salvatore, additional, Pilcher, Brian K., additional, Vecchi, Manuela, additional, Sigismund, Sara, additional, and Di Fiore, Pier Paolo, additional

Published
2020
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10. A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior

Author

Sara Sigismund, Giuseppe Viale, Salvatore Pece, Claudia Iavarone, Maria Grazia Malabarba, Giovanni Giangreco, Pier Paolo Di Fiore, Chiara Tordonato, Fabrizio Bianchi, Giovanni Bertalot, Gaetana Serio, Stefano Freddi, Brian K. Pilcher, Manuela Vecchi, Stefania Pirroni, Giorgio Scita, Andrea Disanza, Davide Disalvatore, Giusi Caldieri, Stefano Confalonieri, Irene Schiano Lomoriello, and Daniela Tosoni

Subjects
0301 basic medicine, Epithelial-Mesenchymal Transition, Science, Endocytic cycle, General Physics and Astronomy, Breast Neoplasms, Biology, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Article, Malignant transformation, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Transcription Factor 4, Transforming Growth Factor beta, medicine, Humans, Neoplasm Invasiveness, Epithelial–mesenchymal transition, Neoplasm Metastasis, Autocrine signalling, lcsh:Science, beta Catenin, Multidisciplinary, Oncogene, General Chemistry, medicine.disease, Cadherins, Endocytosis, Cell invasion, Gene Expression Regulation, Neoplastic, Adaptor Proteins, Vesicular Transport, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, lcsh:Q, Female, Signal transduction, Carcinogenesis, Signal Transduction
Abstract

The subversion of endocytic routes leads to malignant transformation and has been implicated in human cancers. However, there is scarce evidence for genetic alterations of endocytic proteins as causative in high incidence human cancers. Here, we report that Epsin 3 (EPN3) is an oncogene with prognostic and therapeutic relevance in breast cancer. Mechanistically, EPN3 drives breast tumorigenesis by increasing E-cadherin endocytosis, followed by the activation of a β-catenin/TCF4-dependent partial epithelial-to-mesenchymal transition (EMT), followed by the establishment of a TGFβ-dependent autocrine loop that sustains EMT. EPN3-induced partial EMT is instrumental for the transition from in situ to invasive breast carcinoma, and, accordingly, high EPN3 levels are detected at the invasive front of human breast cancers and independently predict metastatic rather than loco-regional recurrence. Thus, we uncover an endocytic-based mechanism able to generate TGFβ-dependent regulatory loops conferring cellular plasticity and invasive behavior., It is unclear if genetic alterations in endocytic proteins play a causal role in high incidence human cancers. Here, the authors report the oncogenic role of Epsin3 (EPN3) in breast cancer, and show EPN3 to drive tumorigenesis through induction of a partial epithelial mesenchymal transition state and a TGFβ-dependent regulatory loop that promotes cellular plasticity and invasive behaviour.

Published
2019

11. Author Correction: A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration

Author

Corallino, Salvatore, primary, Malinverno, Chiara, additional, Neumann, Beate, additional, Tischer, Christian, additional, Palamidessi, Andrea, additional, Frittoli, Emanuela, additional, Panagiotakopoulou, Magdalini, additional, Disanza, Andrea, additional, Malet-Engra, Gema, additional, Nastaly, Paulina, additional, Galli, Camilla, additional, Luise, Chiara, additional, Bertalot, Giovanni, additional, Pece, Salvatore, additional, Di Fiore, Pier Paolo, additional, Gauthier, Nils, additional, Ferrari, Aldo, additional, Maiuri, Paolo, additional, and Scita, Giorgio, additional

Published
2018
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13. A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration

Author

Corallino, Salvatore, primary, Malinverno, Chiara, additional, Neumann, Beate, additional, Tischer, Christian, additional, Palamidessi, Andrea, additional, Frittoli, Emanuela, additional, Panagiotakopoulou, Magdalini, additional, Disanza, Andrea, additional, Malet-Engra, Gema, additional, Nastaly, Paulina, additional, Galli, Camilla, additional, Luise, Chiara, additional, Bertalot, Giovanni, additional, Pece, Salvatore, additional, Di Fiore, Pier Paolo, additional, Gauthier, Nils, additional, Ferrari, Aldo, additional, Maiuri, Paolo, additional, and Scita, Giorgio, additional

Published
2018
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