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1. Deacetylation of p53 modulates its effect on cell growth and apoptosis.

Author

Luo, Jianyuan, Su, Fei, Chen, Delin, Shiloh, Ariel, and Gu, Wei

Subjects
ACETYLATION, TUMOR genetics, TRANSCRIPTION factors, NUCLEAR receptors (Biochemistry)
Abstract

Shows that the deacetylation of the tumor suppressor and transcriptional factor p53 is mediated by a histone deacetylase-1 (HDAC1)-containing complex. Purification of a p53 target protein which has been identified as a component of the NuRD complex; Results, which show that deacetylation and functional interactions by the PID/MTA2-associated NuRD complex may represent an important pathway to regulate p53 function.

Published
2000
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