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Deacetylation of p53 modulates its effect on cell growth and apoptosis.
- Source :
- Nature; 11/16/2000, Vol. 408 Issue 6810, p377, 5p, 11 Diagrams, 5 Graphs
- Publication Year :
- 2000
-
Abstract
- Shows that the deacetylation of the tumor suppressor and transcriptional factor p53 is mediated by a histone deacetylase-1 (HDAC1)-containing complex. Purification of a p53 target protein which has been identified as a component of the NuRD complex; Results, which show that deacetylation and functional interactions by the PID/MTA2-associated NuRD complex may represent an important pathway to regulate p53 function.
- Subjects :
- ACETYLATION
TUMOR genetics
TRANSCRIPTION factors
NUCLEAR receptors (Biochemistry)
Subjects
Details
- Language :
- English
- ISSN :
- 00280836
- Volume :
- 408
- Issue :
- 6810
- Database :
- Complementary Index
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 3791858
- Full Text :
- https://doi.org/10.1038/35042612