1. An indole diterpenoid isolated from the fungus Drechmeria sp. and its antimicrobial activity.
- Author
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Liang, Jia-Hao, Huo, Xiao-Kui, Cheng, Zhong-Bin, Sun, Cheng-Peng, Zhao, Jian-Chao, Kang, Xiao-Hui, Zhang, Tian-Yuan, Chen, Zhong-Jian, Yang, Tian-Mei, Wu, Ying-Ying, Deng, Xiao-Peng, and Zhang, Yi-Xuan
- Subjects
NUCLEAR magnetic resonance - Abstract
One new indole diterpenoid, drechmerin I (1), was isolated from the fermentation broth of Drechmeria sp. isolated from the root of Panax notoginseng. Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I (1) was assayed for its antimicrobial activity against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin I (1) showed antimicrobial activities against B. subtillis with an MIC value of 200 μg/mL. The interaction of S. aureus peptide deformylase with drechmerin I (1) was investigated by molecular docking. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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