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An indole diterpenoid isolated from the fungus Drechmeria sp. and its antimicrobial activity.
- Source :
- Natural Product Research; Oct2019, Vol. 33 Issue 19, p2770-2776, 7p
- Publication Year :
- 2019
-
Abstract
- One new indole diterpenoid, drechmerin I (1), was isolated from the fermentation broth of Drechmeria sp. isolated from the root of Panax notoginseng. Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I (1) was assayed for its antimicrobial activity against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin I (1) showed antimicrobial activities against B. subtillis with an MIC value of 200 μg/mL. The interaction of S. aureus peptide deformylase with drechmerin I (1) was investigated by molecular docking. [ABSTRACT FROM AUTHOR]
- Subjects :
- NUCLEAR magnetic resonance
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 33
- Issue :
- 19
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 137924535
- Full Text :
- https://doi.org/10.1080/14786419.2018.1501050