1. Macrophage membrane-coated iron oxide nanoparticles for enhanced photothermal tumor therapy
- Author
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Guang-Tao Yu, Qian-Fang Meng, Xiaoyun Wei, Shishang Guo, Xing-Zhong Zhao, Zhuhao Wu, Ming Chen, Lang Rao, Yue Sun, Fu-Bing Wang, Wei Liu, and Minghui Zan
- Subjects
Materials science ,Biocompatibility ,Nanoparticle ,Mice, Nude ,Bioengineering ,Breast Neoplasms ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Theranostic Nanomedicine ,Nanomaterials ,chemistry.chemical_compound ,Mice ,In vivo ,Animals ,Humans ,General Materials Science ,Molecular Targeted Therapy ,Electrical and Electronic Engineering ,Low-Level Light Therapy ,Magnetite Nanoparticles ,Immune Evasion ,Mice, Inbred BALB C ,Mice, Inbred ICR ,Mechanical Engineering ,Cell Membrane ,Biological Transport ,General Chemistry ,Hyperthermia, Induced ,Photothermal therapy ,021001 nanoscience & nanotechnology ,Xenograft Model Antitumor Assays ,Ferrosoferric Oxide ,0104 chemical sciences ,Membrane ,RAW 264.7 Cells ,chemistry ,Mechanics of Materials ,Biophysics ,MCF-7 Cells ,Surface modification ,Female ,0210 nano-technology ,Iron oxide nanoparticles - Abstract
Nanotechnology possesses the potential to revolutionize the diagnosis and treatment of tumors. The ideal nanoparticles used for in vivo cancer therapy should have long blood circulation times and active cancer targeting. Additionally, they should be harmless and invisible to the immune system. Here, we developed a biomimetic nanoplatform with the above properties for cancer therapy. Macrophage membranes were reconstructed into vesicles and then coated onto magnetic iron oxide nanoparticles (Fe3O4 NPs). Inherited from the Fe3O4 core and the macrophage membrane shell, the resulting Fe3O4@MM NPs exhibited good biocompatibility, immune evasion, cancer targeting and light-to-heat conversion capabilities. Due to the favorable in vitro and in vivo properties, biomimetic Fe3O4@MM NPs were further used for highly effective photothermal therapy of breast cancer in nude mice. Surface modification of synthetic nanomaterials with biomimetic cell membranes exemplifies a novel strategy for designing an ideal nanoplatform for translational medicine.
- Published
- 2018