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Macrophage membrane-coated iron oxide nanoparticles for enhanced photothermal tumor therapy.
- Source :
- Nanotechnology; 4/3/2018, Vol. 29 Issue 13, p1-1, 1p
- Publication Year :
- 2018
-
Abstract
- Nanotechnology possesses the potential to revolutionize the diagnosis and treatment of tumors. The ideal nanoparticles used for in vivo cancer therapy should have long blood circulation times and active cancer targeting. Additionally, they should be harmless and invisible to the immune system. Here, we developed a biomimetic nanoplatform with the above properties for cancer therapy. Macrophage membranes were reconstructed into vesicles and then coated onto magnetic iron oxide nanoparticles (Fe<subscript>3</subscript>O<subscript>4</subscript> NPs). Inherited from the Fe<subscript>3</subscript>O<subscript>4</subscript> core and the macrophage membrane shell, the resulting Fe<subscript>3</subscript>O<subscript>4</subscript>@MM NPs exhibited good biocompatibility, immune evasion, cancer targeting and light-to-heat conversion capabilities. Due to the favorable in vitro and in vivo properties, biomimetic Fe<subscript>3</subscript>O<subscript>4</subscript>@MM NPs were further used for highly effective photothermal therapy of breast cancer in nude mice. Surface modification of synthetic nanomaterials with biomimetic cell membranes exemplifies a novel strategy for designing an ideal nanoplatform for translational medicine. [ABSTRACT FROM AUTHOR]
- Subjects :
- IRON oxide nanoparticles
PHOTOTHERMAL effect
Subjects
Details
- Language :
- English
- ISSN :
- 09574484
- Volume :
- 29
- Issue :
- 13
- Database :
- Complementary Index
- Journal :
- Nanotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 128051392
- Full Text :
- https://doi.org/10.1088/1361-6528/aaa7c7