1. Five New Cucurbitane-Type Triterpenoid Glycosides from the Rhizomes of Hemsleya penxianensis with Cytotoxic Activities
- Author
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Xudong Xu, De-Li Chen, Guo-Xu Ma, Meng Yu, Rong-Tao Li, Yang-Yang Liu, and Bo-Wen Wang
- Subjects
Magnetic Resonance Spectroscopy ,Cell Survival ,Pharmaceutical Science ,Cucurbitane ,01 natural sciences ,Article ,Analytical Chemistry ,HeLa ,lcsh:QD241-441 ,chemistry.chemical_compound ,Inhibitory Concentration 50 ,lcsh:Organic chemistry ,Cell Line, Tumor ,Drug Discovery ,Humans ,Glycosides ,Physical and Theoretical Chemistry ,Cytotoxicity ,chemistry.chemical_classification ,biology ,Traditional medicine ,Hemsleya penxianensis ,Molecular Structure ,010405 organic chemistry ,Plant Extracts ,Organic Chemistry ,Glycoside ,biology.organism_classification ,Antineoplastic Agents, Phytogenic ,In vitro ,Triterpenes ,0104 chemical sciences ,Rhizome ,010404 medicinal & biomolecular chemistry ,Cucurbitaceae ,chemistry ,Chemistry (miscellaneous) ,Cell culture ,Molecular Medicine ,cucurbitane-typetriterpenoid glycosides ,cytotoxicity - Abstract
Five new cucurbitane-typetriterpenoid glycosides, named Xuedanoside F&ndash, J (1&ndash, 5), were obtained from the rhizomes of Hemsleya penxianensis (Xue dan), which belongs to the family of Cucurbitaceae. These new compounds were elucidated byspectroscopic analysis, including 1D, 2D NMR, and HR-ESI-MS spectra. Additionally, all the isolates were evaluated for cytotoxicity against three human cancer cell lines (Hela, MCF-7, and A-549) with the IC50 ranging from 2.25 to 49.44 µ, M in vitro with treatment 48 h and showed low cytotoxicity in human normal liver L-02 cells (IC50 >, 50 µ, M). Compound 5 showed the most significant cytotoxic activity with the IC50 value of 2.25, 4.72, and 5.33 µ, M in 48 h, respectively.
- Published
- 2019