Five New Cucurbitane-Type Triterpenoid Glycosides from the Rhizomes of Hemsleya penxianensis with Cytotoxic Activities

Authors :: Xudong Xu
De-Li Chen
Guo-Xu Ma
Meng Yu
Rong-Tao Li
Yang-Yang Liu
Bo-Wen Wang
Source :: Molecules, Volume 24, Issue 16, Molecules, Vol 24, Iss 16, p 2937 (2019)
Publication Year :: 2019
Publisher :: MDPI, 2019.
Abstract: Five new cucurbitane-typetriterpenoid glycosides, named Xuedanoside F&ndash J (1&ndash 5), were obtained from the rhizomes of Hemsleya penxianensis (Xue dan), which belongs to the family of Cucurbitaceae. These new compounds were elucidated byspectroscopic analysis, including 1D, 2D NMR, and HR-ESI-MS spectra. Additionally, all the isolates were evaluated for cytotoxicity against three human cancer cell lines (Hela, MCF-7, and A-549) with the IC50 ranging from 2.25 to 49.44 &micro M in vitro with treatment 48 h and showed low cytotoxicity in human normal liver L-02 cells (IC50 &gt 50 &micro M). Compound 5 showed the most significant cytotoxic activity with the IC50 value of 2.25, 4.72, and 5.33 &micro M in 48 h, respectively.

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