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1. Peripheral human γδ T cells control growth of both avirulent and highly virulent strains of Francisella tularensis in vitro

Author

Rowland, Caroline A., Hartley, M. Gill, Flick-Smith, Helen, Laws, Thomas R., Eyles, Jim E., and Oyston, Petra C.F.

Subjects
*T cells, *MICROBIAL virulence, *FRANCISELLA tularensis, *BACTERIAL diseases, *IMMUNOGLOBULINS, *LYMPHOCYTES, *PATHOGENIC microorganisms, *COMMUNICABLE diseases
Abstract

Abstract: In this paper we evaluate the role of human γδ T cells in control of Francisella tularensis infection. Using an in vitro model of infection, a reduction in bacterial numbers was detected in the presence of human γδ T cells for both attenuated LVS and virulent SCHU S4 strains of F. tularensis. Antibody neutralisation of IFN-γ caused an increase in survival of F. tularensis LVS suggesting that γδ T cell-mediated control of F. tularensis infection is partially mediated by IFN-γ. [Copyright &y& Elsevier]

Published
2012
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