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Peripheral human γδ T cells control growth of both avirulent and highly virulent strains of Francisella tularensis in vitro
- Source :
-
Microbes & Infection . Jul2012, Vol. 14 Issue 7/8, p584-589. 6p. - Publication Year :
- 2012
-
Abstract
- Abstract: In this paper we evaluate the role of human γδ T cells in control of Francisella tularensis infection. Using an in vitro model of infection, a reduction in bacterial numbers was detected in the presence of human γδ T cells for both attenuated LVS and virulent SCHU S4 strains of F. tularensis. Antibody neutralisation of IFN-γ caused an increase in survival of F. tularensis LVS suggesting that γδ T cell-mediated control of F. tularensis infection is partially mediated by IFN-γ. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 12864579
- Volume :
- 14
- Issue :
- 7/8
- Database :
- Academic Search Index
- Journal :
- Microbes & Infection
- Publication Type :
- Academic Journal
- Accession number :
- 76618802
- Full Text :
- https://doi.org/10.1016/j.micinf.2012.02.001