Descriptor: "cembranolides" / Journal: marine drugs - Searchworks@Jio Institute Digital Library Search Results

Author: Gallardo, Amalia B., Díaz-Marrero, Ana R., de la Rosa, José M., D’Croz, Luis, Perdomo, Germán, Cózar-Castellano, Irene, Darias, José, and Cueto, Mercedes
Abstract: Two new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were found to activate the proliferation of pancreatic insulin-producing (beta) cells. [ABSTRACT FROM AUTHOR]
Published: 2018
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Author: Chang-Yih Duh and Shang-Kwei Wang
Subjects: Lobophytum michaelae, cembranolides, cytotoxicity, Biology (General), QH301-705.5
Abstract: Six new cembranolides, michaolides L–Q (1–6), and a known cembranolide, lobomichaolide (7) were isolated from the CH2Cl2 extract of the soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1–7 and their cytotoxicity against selected cell lines were evaluated.
Published: 2012
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Author: Amalia B. Gallardo, Ana R. Díaz-Marrero, José M. de la Rosa, Luis D’Croz, Germán Perdomo, Irene Cózar-Castellano, José Darias, and Mercedes Cueto
Subjects: Leptogorgia, cembranolides, furanocembranolides, diketocembranolides, seco-furanocembranolides, chloro-furanocembranolides, pancreatic beta-cells, Biology (General), QH301-705.5
Abstract: Two new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were found to activate the proliferation of pancreatic insulin-producing (beta) cells.
Published: 2018
Full Text: View/download PDF

Author: Shang-Kwei Wang and Chang-Yih Duh
Abstract: Six new cembranolides, michaolides L-Q (1-6), and a known cembranolide, lobomichaolide (7) were isolated from the CH2Cl2 extract of the soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1-7 and their cytotoxicity against selected cell lines were evaluated. [ABSTRACT FROM AUTHOR]
Published: 2012
Full Text: View/download PDF

Author: Wang SK and Duh CY
Subjects: Animals, Antineoplastic Agents chemistry, Antineoplastic Agents isolation & purification, Antiviral Agents chemistry, Antiviral Agents isolation & purification, Cell Line, Tumor, Cytomegalovirus drug effects, Diterpenes chemistry, Diterpenes isolation & purification, Drug Discovery, Humans, Inhibitory Concentration 50, Lactones chemistry, Lactones isolation & purification, Lactones pharmacology, Marine Toxins chemistry, Marine Toxins isolation & purification, Mice, Molecular Structure, Neoplasms drug therapy, Pacific Ocean, Stereoisomerism, Taiwan, Anthozoa chemistry, Antineoplastic Agents pharmacology, Antiviral Agents pharmacology, Diterpenes pharmacology, Marine Toxins pharmacology
Abstract: Six new cembranolides, michaolides L-Q (1-6), and a known cembranolide, lobomichaolide (7) were isolated from the CH₂Cl₂ extract of the soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1-7 and their cytotoxicity against selected cell lines were evaluated.
Published: 2012
Full Text: View/download PDF

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