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Your search keyword '"le Coutre, Philipp"' showing total 10 results
Start Over Author "le Coutre, Philipp" Journal leukemia & lymphoma
10 results on '"le Coutre, Philipp"'

1. Up-regulatedMSI2is associated with more aggressive chronic myeloid leukemia

Author

Kaeda, Jaspal, primary, Ringel, Frauke, additional, Oberender, Christian, additional, Mills, Ken, additional, Quintarelli, Concetta, additional, Pane, Fabrizio, additional, Koschmieder, Steffen, additional, Slany, Robert, additional, Schwarzer, Rolf, additional, Saglio, Giuseppe, additional, Hemmati, Philipp, additional, van Lessen, Antje, additional, Amini, Leila, additional, Gresse, Martin, additional, Vagge, Elisabetta, additional, Burmeister, Thomas, additional, Serra, Anna, additional, Carson, Anne, additional, Schwarz, Michaela, additional, Westermann, Jörg, additional, Jundt, Franziska, additional, Dörken, Bernd, additional, and le Coutre, Philipp, additional

Published
2015
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2. Differential expression ofSHP-1in chronic myeloid leukemia

Author

Kaeda, Jaspal, primary, Neuman, Daniel, additional, Bonecker, Simone, additional, Mills, Ken, additional, Oberender, Christian, additional, Amini, Leila, additional, Ringel, Frauke, additional, Serra, Anna, additional, Schwarz, Michaela, additional, Dörken, Bernd, additional, Zalcberg, Ilana, additional, and le Coutre, Philipp, additional

Published
2014
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3. JAK2 V617F allele burden quantified by real time quantitative polymerase chain reaction and competitive polymerase chain reaction in patients with chronic myeloproliferative neoplasia

Author

Kaeda, Jaspal, primary, Bonamino, Martin, additional, Ayres-Silva, Jackline, additional, Solza, Cristiana, additional, Ringel, Frauke, additional, Blau, Olga, additional, Daumas, Ademo, additional, Oberender, Christian, additional, Dörken, Bernd, additional, le Coutre, Philipp, additional, and Zalcberg, Ilana, additional

Published
2013
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7. JAK2 V617F allele burden quantified by real time quantitative polymerase chain reaction and competitive polymerase chain reaction in patients with chronic myeloproliferative neoplasia.

Author

Kaeda, Jaspal, Bonamino, Martin, Ayres-Silva, Jackline, Solza, Cristiana, Ringel, Frauke, Blau, Olga, Daumas, Ademo, Oberender, Christian, Dörken, Bernd, le Coutre, Philipp, and Zalcberg, Ilana

Subjects
POLYMERASE chain reaction, MYELOPROLIFERATIVE neoplasms, GENE frequency, CLINICAL trials, GRANULOCYTES, THERAPEUTICS
Abstract

Assessing the clinical significance of JAK2 V617F mutant allele burden is complicated by a myriad of techniques reported to detect and quantify the mutation. As a consequence, the level of sensitivity and how the data is reported vary. Harmonization of well-defined molecular studies would permit evaluation of the clinical significance of measuring allele burden and rapid determination of the efficacy of novel agents for the treatment of chronic myeloproliferative neoplasia via multicenter clinical trials, at the subclinical level. Here we report a comparison between the widely available TaqMan quantitative real time polymerase chain reaction (Q-PCR) and competitive PCR (C-PCR) assays. We found that the tumor load was invariably greater when measured by C-PCR compared to that recorded by Q-PCR. Furthermore, none of the samples converted from undetectable to detectable when the enriched granulocyte (GR) fraction was tested. While a difference in the V617F allele levels was detected between GR fraction and whole blood, this was not statistically significant. [ABSTRACT FROM AUTHOR]

Published
2014
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8. Long-term follow-up of patients with Philadelphia chromosome-positive chronic myeloid leukemia after stem cell mobilization under imatinib.

Author

Kim, Theo D., Schwarz, Michaela, Kreuzer, Karl-Anton, Kaeda, Jaspal, Movassaghi, Kamran, Grille, Peggy, Daniel, Peter T., Dörken, Bernd, and le Coutre, Philipp

Subjects
LETTERS to the editor, TREATMENT of chronic myeloid leukemia
Abstract

A letter to the editor is presented regarding the long-term effect of stem cell mobilization under imatinib mesylate (IM) therapy for patients with Philadelphia (Ph) chromosome-positive chronic myeloid leukemia (CML).

Published
2011
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9. Differential expression of SHP-1 in chronic myeloid leukemia.

Author

Kaeda, Jaspal, Neuman, Daniel, Bonecker, Simone, Mills, Ken, Oberender, Christian, Amini, Leila, Ringel, Frauke, Serra, Anna, Schwarz, Michaela, Dörken, Bernd, Zalcberg, Ilana, and le Coutre, Philipp

Subjects
GENE expression, CHRONIC myeloid leukemia, GENETICS
Abstract

A letter to the editor is presented in response to the article regarding the differential expression of SHP-1 in chronic myeloid leukemia.

Published
2015
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10. Sequencing of NUMB transcripts in chronic myeloid leukemia detects two single nucleotide polymorphisms.

Author

Oberender, Christian, Kaeda, Jaspal, Pawlaczyk-Peter, Bärbel, Daniel, Peter, Arnold, Renate, Dörken, Bernd, and le Coutre, Philipp

Subjects
GENETIC transcription, CHRONIC myeloid leukemia, SINGLE nucleotide polymorphisms, GENETIC polymorphisms, LEUCOCYTOSIS
Abstract

The article discusses research which investigated NUMB gene transcript sequencing and mutations in chronic myeloid leukemia (CML) patients. Topics explored include the significant role of Musashi 2 (MSI2) gene transcripts in CML transformation, the analysis of archived RNA extracted from CML patients involved in the study, and the observed lack of association between MSI2 and single nucleotide polymorphisms (SNP) recorded.

Published
2013
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