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The article highlights the effectiveness of low-pressure gas chromatography (LPGC)-mass spectrometry (MS)) as a solution for fast, sensitive and robust gas chromatography-mass spectrometry (GC-MS) analysis. Topics covered include the practicality of LPGC in nearly any gas chromatography (GC) application using MS for detection, the configuration options for LPGC, and the features, excellent performance, and practical utility of LPGC-MS.

In this article the author discusses his experience of work on gas chromatography. It mentions working with chromatography pioneer Leslie Ettre on various projects at food firm PerkinElmer from that time and onward past his retirement who possessed insights and knowledge. It also mentions that the GC Applications Lab had acquired two IBM PC-XT computers with a printer.

The article presents the discussion on leak free installation using MS Vacuum making data acqusition challenging.

The article offers the author's view on the liquid chromatography (LC) methods that should be used when scaling an isocratic separation method. The author states the use of fundamental equation as a guide in method conversion. The author notes that the linear velocity is independent of column length but proportional to cross-sectional area of column. The author mentions that the pressure in LC separation is important to pressure capability of instrument.

The article offers information on Gas Chromatography (GC) separations, involves making informed choices around stationary‑phase chemistry and column temperature programs. Topic include Column internal diameter (dc) affects efficiency, retention, carrier flow rate, capacity, and pressure drop across the column, and it is inversely proportional to column efficiency— halve the column diameter, and double efficiency, increasing resolution by a factor of 1.4.

The article discusses that there are so many potential causes for reduced peak size that an inexperienced gas chromatography (GC) user may not know where to begin in the troubleshooting process. It mentions the inlet and detector temperatures have been set correctly within the acquisition method; and also mentions that the carrier gas flow programming method is correct by selecting either constant pressure or constant flow operating modes.

The article discusses the advantages of using nitrogen in capillary gas chromatography. These include nitrogen's efficiency in at its optimum linear velocity in producing the narrowest chromatographic peaks, optimization of methods without sacrificing the big advantage of efficiency and nitrogen's generation of in situ using generators that is readily available, less expensive, and safe.

The article focuses on the translation of carrier gas from helium to hydrogen in gas chromatography (GC) for better and faster results. It mentions various factors to consider during translation including linear velocity, retention factor and flow rate, and suggests to use method translation software. It suggests to inquire from a manufacturer regarding the suitability of hydrogen as a carrier gas with various detection systems which require additional settings.