1. Experimental Chronic Wasting Disease in Wild Type VM Mice
- Author
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Min-Jeong Kim, In-Soo Cho, Aru Balachandran, Won-Yong Lee, Young-Pyo Choi, Hyo-Jin Kim, Eun-Im Yun, Kyung-Je Park, Hyun-Joo Sohn, Dong-Seob Tark, and Yoon-Hee Lee
- Subjects
Genetically modified mouse ,General Veterinary ,biology ,Transmission (medicine) ,animal diseases ,Wild type ,Brain ,Mice, Inbred Strains ,Chronic wasting disease ,Odocoileus ,biology.organism_classification ,medicine.disease ,Immunohistochemistry ,Virology ,Disease Models, Animal ,Mice ,Species Specificity ,Republic of Korea ,medicine ,Animals ,Wasting Disease, Chronic ,Syrian golden hamsters ,Prion protein ,Rocky Mountain elk - Abstract
Chronic wasting disease (CWD) is a naturally occurring prion disease in North American deer (Odocoileus species), Rocky mountain elk (Cervus elaphus nelsoni) and moose (Alces alces). The disease was first confirmed in the Republic of Korea in 2001, and subsequent cases were diagnosed in 2004, 2005 and 2010. The experimental host range of CWD includes ferrets, several species of voles, white-footed mice, deer mice and Syrian golden hamsters. In addition, CWD was transmitted to the transgenic mouse over-expressing elk or deer prion protein efficiently, but not to wild type mouse. Here, we report the experimental transmission of elk CWD to conventional VM/Dk mice reaching 100% attack rate after second passage. The CWD-prion-affected wild type mice will be a useful model for future CWD studies.
- Published
- 2013
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